5-alpha reductase

Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic acid (IC50 = 160.3 +/- 24.62 microM) but is weaker than finasteride (IC50 = 0.38 +/- 0.06 microM). Torilin has immunomodulatory, hepatoprotective, and anti-inflammatory properties, it inhibits inflammation by limiting TAK1-mediated MAP kinase and NF-κB activation, it can attenuate arthritis severity, modify leukocyte activations in dLNs or joints, and restore serum and splenocyte cytokine imbalances. Torilin inhibits melanin production in alpha-melanocyte stimulating hormone-activated B16 melanoma cells, with an IC(50) value of 25 microM. Torilin shows excellent antimicrobial activity against Bacillus subtilis ATCC 6633 spores and vegetative cells. Torilin has a potent anti-angiogenic activity both in vivo and in vitro, and it may have a strong activity to suppress tumorigenesis by inhibition of tumor invasion, it reverses multidrug-resistance in cancer cells, it can potentiate the cytotoxicities of adriamycin, vinblastine, taxol and colchicine against multidrug-resistant KB-V1 and MCF7/ADR cells.

Finasteride (MK-906) is an oral inhibitor of active testosterone 5-alpha-reductase and Ki value is 10 nM.

Dutasteride (GI 198745) is a 5-alpha-reductase inhibitor that inhibits both type-1 and type2 isoforms of the enzyme and is used to treat benign prostatic hyperplasia.

Alpha-Estradiol (Epiestradiol) is an estrogen that inhibits 5alpha-reductase and has potential in the study of androgenetic alopecia.

12-O-Methylcarnosic acid is a diterpene carnosic acid isolated from Salvia microphylla, is an active constituent of 5α-Reductase inhibition with an IC50 value of 61.7 μM. 12-O-Methylcarnosic acid has Antioxidant activity, it is effective preventing gastric lesions. 12-O-Methylcarnosic acid can suppress melanin production with downregulation of Tyrosinase expression in HMV-II melanoma cells. 12-O-Methylcarnosic acid may have anti-diabetic activity, it is able to significantly activate peroxisome proliferator-activated receptor (PPAR)γ.

CGP-53153 is a steroidal inhibitor of 5 alpha-reductase, with IC50 values of 36 nM in rat prostatic tissue and 262 nM in human prostatic tissue.

5α-reductase-IN-1 is a potent inhibitor of the enzyme 5α-reductase. This compound is primarily employed in research studies to investigate its potential efficacy in treating patterned alopecia. It is commonly used in combination with minoxidil, a well-known treatment for hair loss.

MK 0434 is an orally active steroidal 5 alpha-reductase inhibitor.

Isomer-Turosteride (Isomer-Turosteride(Isomer-137099-09-3)) is a novel 5 alpha-reductase inhibitor.The antiprostatic effect of Isomer-Turosteride in adult rats is associated with the inhibition of the conversion of T to DHT.Isomer-Turosteride induces a decrease in prostate DHT independent of a secondary increase in T. Isomer-Turosteride has anticancer activity and inhibits the growth of tumor cells. Turosteride has anticancer activity and inhibits the growth of tumor cells. Translated with www.DeepL.com/Translator (free version)

5β-Dutasteride (5β, S-configuration of Dutasteride) is a potent inhibitor of both 5 alpha-reductase isozymes.

TBHBA (2,4,6-Tribromo-3-hydroxybenzoic acid) is a brominated aromatic compound that inhibits the enzymes cyclooxygenase-2 (COX-2), lipoxygenase (LOX), 5-lipoxygenase (5-LOX), 5-alpha reductase, and tyrosinase, and exhibits a variety of anti-inflammatory and antioxidant effects.

Ono-3805 is an inhibitor of nonsteroidal 5 alpha-reductase.

RMI-18341 is a Testosterone 5 alpha reductase inhibitor.

FK-143 is a 5-alpha reductase inhibitor.

FCE-28175 is a 5-alpha reductase inhibitor and hormone antagonist.

FCE-27837 is a 5-alpha reductase inhibitor and hormone antagonist.

Fce 28260 is a 5 alpha-reductase inhibitor.

Finasteride-D9 is a deuterated compound of Finasteride. Finasteride (T0488) has a CAS number of 98319-26-7. Finasteride (T0488) is an oral inhibitor of active testosterone 5-alpha-reductase and Ki value is 10 nM.

Grandifloroside shows good antioxidative and potent anti-inflammatory activities, it also exhibits potent inhibitory activity against TNF-α and 5α-reductase, suggests that it might be developed as a source of potent anti-oxidative and anti-inflammatory ag