Phenylpropanoids

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Phenylpropanoids are a large class of plant secondary metabolites derived from aromatic amino acids phenylalanine in most plants or tyrosine in partial monocots. It mainly includes flavonoids, monolignols, phenolic acids, stilbenes, and coumarins. Phenylpropanoids are widely distributed in the plant kingdom and play vital roles in plant development by acting as essential components of cell walls, protectants against high light and UV radiation, phytoalexins against herbivores and pathogens, floral pigments to mediate plant–pollinator interactions. In addition, phenylpropanoids possess diverse biological activities that are beneficial to human health.

Maytansinol

T1601657103-68-1

Maytansinol (Ansamitocin P-0) inhibits microtubule assembly and causes microtubule disassembly in vitro.

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Chlorogenic Acid

T2805327-97-9

Chlorogenic acid is a natural phenol found in honeysuckle. Chlorogenic acid has a wide range of biological activities including anti-inflammatory, antioxidant, antitumor, antimicrobial, and neuroprotective.

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L-DOPA

T084859-92-7

L-DOPA (Levodopa) is an amino acid precursor of dopamine with antiparkinsonian properties. It is a prodrug converted to dopamine by DOPA decarboxylase and can cross the blood-brain barrier. In the brain, levodopa is decarboxylated to dopamine, stimulating dopaminergic receptors and compensating for depleted endogenous dopamine in Parkinson's disease. To ensure adequate concentrations reach the central nervous system, levodopa is administered with carbidopa, a decarboxylase inhibitor that does not cross the blood-brain barrier, reducing peripheral decarboxylation and increasing CNS dopamine delivery.

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Magnolol

T3000528-43-8

Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.

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3-Feruloylquinic acid

TN12621899-29-2

3-O-Feruloylquinic acid is a protease inhibitor, it exerts moderate inhibitory effect against AIV (H5N1) in vitro.

$172

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Bimatoprost acid

T2093938344-08-0

Bimatoprost acid (17-phenyl trinor PGF2α) is a metabolically stable analog of PGF2α and has a potential antagonistic activity for the FP receptor. It has a relative potency of 756% compared to PGF2α for binding to the FP receptor on ovine luteal cells.

$135

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beta-Asarone

T4S19625273-86-9

1. beta-Asarone (Cis-Isoelemicin) may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in SAMP8 mice. 3. The co-administration of beta-Asarone(Cis-Isoasarone) and l-dopa may contribute to the treatment of 6-OHDA-induced damage in rats by inhibiting autophagy activity. 4. Beta-Asarone exhibits anti-inflammatory effects by suppressing the production of pro-inflammatory mediators through NF-κB signaling and the JNK pathways in activated microglial cells and might be developed as a promising candidate to treat various neuroinflammatory diseases.

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Salviaflaside

TN1127178895-25-5

Salviaflaside is the main bioactive component of Prunella vulgaris and has antioxidant activity.

$100

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Methylsticin

TN2347495-85-2

Methysticin is a kavalactone isolated from the kava roots. Methylsticin (Methysticin) exhibit osteoclast formation inhibitory activity. It inhibits activation of NF-χB in lung adenocarcinoma tissue, activates Nrf2 in neurons and astroglia, decreases peak amplitude of voltage-gated Na+ channels in hippocampal neurons, and suppresses growth of Fusarium, Trichoderma, and Colletotrichum.

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Forsythoside E

T5S109493675-88-8

Forsythoside E is a natutal product isolated from fruits of forsythia suspensa.

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Secodihydro-hydramicromelin B

TN49801212148-58-7

Secodihydro-hydramicromelin B ((rac)-Secodihydro-hydramicromelin B) is a natural product extracted from Equisetum hyemale L.

$798

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(2E)-3-(1,3-Benzodioxol-5-yl)-2-propenoic acid

TN707438489-76-8

(2E)-3-(1,3-Benzodioxol-5-yl)-2-propenoic acid displays EC50 values of 73.5 μM against T. cruzi. trypomastigotes.

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N-p-trans-Coumaroyltyramine

TN103036417-86-4

N-p-trans-Coumaroyltyramine is a natural product and an acetylcholinesterase (AChE) inhibitor with an IC50 of 122 μM. It also exhibits anti-trypanosomal activity with an IC50 of 13.3 μM for T. brucei rhodesiense.

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Fraxetin

T2909574-84-5

Fraxetin (7,8-dihydroxy-6-methoxy coumarin) has dual-antioxidative ,hepatoprotective and antihyperglycemic functions, it shows potent protective effects against CCl4 induced oxidative stress and hepatic fibrosis, has a marked inhibitory effect on S.aureus proliferation. It increased the level of Nrf2 ARE, and HO-1, inhibit the formation of ROS, cytochrome c release, activation of caspase-3 and 9, and suppressed the up-regulation of Bax.

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Osthole

T2848484-12-8

Osthole (Osthol), a potential inhibitor of histamine H1 receptor, has been shown to stimulate osteoblast proliferation and differentiation.

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Salvianolic acid D

TN2173142998-47-8

Salvianolic acid D ((R,E)-2-((3-(2-(carboxymethyl)-3,4-dihydroxyphenyl)acryloyl)oxy)-3-(3,4-dihydroxyphenyl)propanoic acid) and notoginseng triterpenes can promote EA-hy926 and expression of protein with protective effects on angiogenesis in EA-hy926 cells in vitro.

$180

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4-O-Cinnamoylquinic acid

TN66475509-70-6

4-O-Cinnamoylquinic acid is a small molecule compound extracted from the dried fruits of Casearia grewiifolia, which has an inhibitory effect on prostaglandins and inhibits the production of superoxide anions in human neutrophils.

$148

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4-Demethyldeoxypodophyllotoxin

T833213590-93-0

4-Demethyldeoxypodophyllotoxin, an aryl tetrahydronaphthalenyl lignan analog from the roots of Podophyllum peltatum, has anticancer activity and modulates the Chk-2 signaling pathway in MCF-7 breast cancer cells.

$122

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coniferyl ferulate

T3S001263644-62-2

Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis. It shows strong inhibition of human placental GST (IC50: 0.3 μM). It also reverses multidrug resistance and downregulates P-glycoprotein.

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Psoralen

T294266-97-7

Psoralen (Ficusin) is a furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division.

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Scoparone

T2729120-08-1

Scoparone (Aesculetin dimethyl ether) can be found in a number of food items such as sweet orange, wild celery, mandarin orange (clementine, tangerine), and lemon. It is found in the Chinese herb Artemisia scoparia and has been studied for its potential pharmacological properties including immunosuppression and vasorelaxation. Scoparone is found in anise. Scoparone is found in several citrus oils.

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Schizandrin A

T292661281-38-7

Schisandrin A, a primary active component extracted from the traditional Eastern medicine Schisandra chinensis, inhibits CYP3A activity, with an IC50 of 6.60 μM and a Ki of 5.83 μM.

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regaloside I

TN7117126239-78-9

Regaloside I is the monomeric component in lily. Regaloside I could be the main constituent in protecting human dermal fibroblasts from UVA-induced morphological changes [1].

$117

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Coniferaldehyde

TN369420649-42-7

Coniferaldehyde can significantly inhibit the growth of viability of strains of Oenococcus oeni. Coniferaldehyde exerts anti-inflammatory properties by inducing heme oxygenase-1(HO-1).

$299

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