PAK

protein kinase A is a family of enzymes whose activity is dependent on cellular levels of cyclic AMP (cAMP). PKA is also known as cAMP-dependent protein kinase . Protein kinase A has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism.

Cat. No.	Product name	CAS No.	Purity
T11342	G-5555 hydrochloride (1648863-90-4 free base)	T11342	98%
T11342	G-5555 hydrochloride is a potent and selective p21-activated kinase 1 (PAK1) inhibitor with a Ki of 3.7 nM.
T6546	IPA-3	42521-82-4	98%
T6546	IPA-3 is a selective non-ATP competitive Pak1 inhibitor with IC50 of 2.5 μM, no inhibition to group II PAKs (PAKs 4-6).
T16429	GNE 2861	1394121-05-1
T16429	GNE 2861 inhibits PAK4, PAK5, and PAK6 (IC50s: 7.5, 36, 126 nM, respectively). GNE 2861 is a PAK inhibitor that shows group II selectivity.
T0646	5-Aminosalicylic Acid	89-57-6	97.88%
T0646	Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the acti...
T4230	PF-3758309 hydrochloride	1279034-84-2	98.11%
T4230	PF-3758309, also known as PF-03758309, is a PAK4 inhibitor, is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potent...
T26704	AZ13705339	2016806-57-6	98.57%
T26704	AZ13705339 is an effective inhibitor of PAK1 with an IC50 of 0.33 nM and a Kd of 0.28 nM. AZ13705339 binds PAK2 with a Kd of 0.32 nM. AZ13705339 can be used in s...
T6840	FRAX486	1232030-35-1	98.81%
T6840	FRAX486 is a potent p21-activated kinase (PAK) inhibitor with IC50 values of 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively.
T11826	LCH-7749944	796888-12-5	99.28%
T11826	LCH-7749944 effectively suppresses the proliferation of human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and induces apopto...
T6626	PF-3758309	898044-15-0	99.37%
T6626	PF-03758309 (IC50=1.3 nM), a pyrrolopyrazole inhibitor of PAK4, has effective ATP-competition.
T16367	NVS-PAK1-1	1783816-74-9	99.74%
T16367	NVS-PAK1-1 is an effective and selective allosteric PAK1 inhibitor (IC50: 5 nM).
T7939	Fingolimod	162359-55-9	99.76%
T7939	Fingolimod is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).
T11342L	G-5555	1648863-90-4	99.76%
T11342L	G-5555 is a potent inhibitor of p21-activated kinase 1 (PAK1) (Kis: 3.7 nM and 11 nM for PAK1 and PAK2, respectively).
T6840L	FRAX486 HCL(1232030-35-1 free base)	T6840L	99.82%
T6840L	FRAX486 HCL is a potent p21-activated kinase (PAK) inhibitor with IC50 values of 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively.
T2539	Fingolimod hydrochloride	162359-56-0	99.83%
T2539	Fingolimod, a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
T4354	KPT9274	1643913-93-2	99.93%
T4354	KPT-9274 is a non-competitive dual inhibitor of PAK4 and NAMPT(IC50= ~120 nM). It is an orally bioavailable small molecule.
T6014	FRAX597	1286739-19-2	99.94%
T6014	FRAX597 is an effective, ATP-competitive inhibitor of group I PAKs, and for PAK1(IC50=8 nM), PAK2(IC50=13 nM), and PAK3 (IC50=19 nM).
T6839	FRAX1036	1432908-05-8	99.95%
T6839	FRAX-1036 is a effective and selective PAK1 inhibitor.
T23160	PIR 3.5	6088-51-3	98%
T23160	negative control of IPA 3, a Pak1 inhibitor