Cysteine Protease

Cysteine proteases, also known as thiol proteases, are enzymes that degrade proteins. These proteases share a common catalytic mechanism that involves a nucleophilic cysteine thiol in a catalytic triad or dyad.

Cat. No.	Product name	CAS No.	Purity
T11896	LV-320	2449093-46-1	98%
T11896	LV-320 is a potent and uncompetitive ATG4B inhibitor with an IC 50 of 24.5 μM and a K d of 16 μM. LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flu...
T13705	GLPG2451	2055015-61-5	98%
T13705	GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. It effectively potentiates low temperature rescued F508del CFTR (EC50: 11.1...
T16474	Petesicatib	1252637-35-6	98%
T16474	Petesicatib is an inhibitor of cathepsin S. Petesicatib used in the research of immune diseases.
T10924	Cysteine protease inhibitor-2	612048-23-4	98%
T10924	Cysteine protease inhibitor 2 is a cysteine protease inhibitor. Cysteine protease inhibitor 2 inhibited DCT116 and PC3 cells with GI50 values of 6.5 μM and 4.4 μ...
T16394	ONO-5334	868273-90-9	98%
T16394	ONO-5334 is an effective and selective cathepsin K inhibitor (Ki: 0.10 nM, 0.049 nM, and 0.85 nM for human, rabbit, and rat cathepsin K, respectively). ONO-5334 ...
T11846	LHVS	170111-28-1	98%
T11846	LHVS effectively blocks T. gondii microneme protein secretion (IC50=10 μM), gliding motility, and cell invasion. LHVS is a potent, non-selective cysteine proteas...
T12819	S130	1160852-22-1	98%
T12819	S130 is a high affinity, selectiveATG4B (a major cysteine protease) inhibitor (IC50 of 3.24 μM).It suppresses autophagy flux.
T13439	(RS)-Butyryltimolol	2320274-78-8	98%
T13439	(RS)-Butyryltimolol is the racemate of Butyryltimolol. Butyryltimolol is an effective prodrug of Timolol that improves the corneal penetration of Timolol [1]. Bu...
T11554	Cathepsin Inhibitor 2	1017931-53-1	98%
T11554	Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor (Ki: <20 nM).
T8677	3,4 Dichloroisocoumarin	51050-59-0	99.9%
T8677	3,4 Dichloroisocoumarin is a granzyme, cathepsin G, and neutrolphil elastase inhibitor
T0789	PMSF	329-98-6	99.9%
T0789	Phenylmethanesulfonyl fluoride (PMSF (Phenylmethylsulfonyl fluoride)) is an enzyme inhibitor that inactivates IRC-50 arvin, subtilisin, and the fatty acid synthe...
T15641	K777	233277-99-1	99.71%
T15641	K777 is a potent, orally active and irreversible inhibitor of cysteine protease. K777 is a potent CYP3A4 inhibitor (IC50= 60 nM). K777 is also a selective CCR4 a...
TJS2216	Aurantiamide acetate	56121-42-7	99.68%
TJS2216	Aurantiamide acetate (Asperglaucide) was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate is a selectiv...
T6015	Cathepsin Inhibitor 1	225120-65-0	99.68%
T6015	Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.
T6040	Aloxistatin	88321-09-9	99.47%
T6040	Aloxistatin (E64d) is an inhibitor of cysteine protease with blood platelet aggregation inhibiting activity. Aloxistatin is an irreversible, membrane-permeable i...
T60812	Cathepsin X-IN-1	2418577-51-0	99.46%
T60812	Cathepsin X-IN-1 (compound 25) reduces the migration of PC-3 cell with low cytotoxic that is a potent inhibitor of Cathepsin X (IC 50 = 7.13 μM) [1].
T6738	Z-FA-FMK	197855-65-5	99.43%
T6738	Z-FA-FMK can irreversibly inhibit cysteine protease and also inhibit effector caspases.
T9710	Dazcapistat	2221010-42-8	99.41%
T9710	Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.
T12051	MIV-247	1352817-76-5	99.31%
T12051	MIV-247 is a selective and potent inhibitor of cathepsin S (Kis 2.1, 4.2, and 7.5 nM for human, mouse, and wild monkey cathepsin S, respectively), which attenuat...
T65868	Z-Lys-OH	2212-75-1	99.11%
T65868	Z-Lys-OH is a competitive inhibitor of papain, a lysine derivative.