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Cysteine Protease

Cysteine proteases, also known as thiol proteases, are enzymes that degrade proteins. These proteases share a common catalytic mechanism that involves a nucleophilic cysteine thiol in a catalytic triad or dyad.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T16394 ONO-5334 868273-90-9 99.60%
ONO-5334
ONO-5334 is a selective, orally active and potent histone K inhibitor with anti-SAR-COV-2 and anti-bone resorption activity for the study of osteoporosis.
T11896 LV-320 2449093-46-1 98%
LV-320
LV-320 is a potent and uncompetitive ATG4B inhibitor with an IC 50 of 24.5 μM and a K d of 16 μM. LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flu...
T13705 GLPG2451 2055015-61-5 98%
GLPG2451
GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. It effectively potentiates low temperature rescued F508del CFTR (EC50: 11.1...
T10924 Cysteine protease inhibitor-2 612048-23-4 98%
Cysteine protease inhibitor-2
Cysteine protease inhibitor 2 is a cysteine protease inhibitor. Cysteine protease inhibitor 2 inhibited DCT116 and PC3 cells with GI50 values of 6.5 μM and 4.4 μ...
T11846 LHVS 170111-28-1 98%
LHVS
LHVS effectively blocks T. gondii microneme protein secretion (IC50=10 μM), gliding motility, and cell invasion. LHVS is a potent, non-selective cysteine proteas...
T12819 S130 1160852-22-1 98%
S130
S130 is a high affinity, selectiveATG4B (a major cysteine protease) inhibitor (IC50 of 3.24 μM).It suppresses autophagy flux.
T13439 (RS)-Butyryltimolol 2320274-78-8 98%
(RS)-Butyryltimolol
(RS)-Butyryltimolol is the racemate of Butyryltimolol. Butyryltimolol is an effective prodrug of Timolol that improves the corneal penetration of Timolol [1]. Bu...
T11554 Cathepsin Inhibitor 2 1017931-53-1 98%
Cathepsin Inhibitor 2
Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor (Ki: <20 nM).
T6037 E-64 66701-25-5 99.95%
E-64
E-64 (Proteinase inhibitor E 64) is an irreversible and specific cysteine protease inhibitor. The IC50 of E-64 for papain is 9 nM.
T13911 Tacalcitol monohydrate 93129-94-3 99.93%
Tacalcitol monohydrate
Tacalcitol monohydrate(Curatoderm monohydrate), a vitamin D3 analog that promotes bone development by regulating calcium ions, can be used to study psoriasis.
T16089 MK-0674 887781-62-6 99.91%
MK-0674
MK-0674 is an orally available, selective and potent cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S. It can be used in metabol...
T8677 3,4 Dichloroisocoumarin 51050-59-0 99.9%
3,4 Dichloroisocoumarin
3,4 Dichloroisocoumarin is a granzyme, cathepsin G, and neutrolphil elastase inhibitor
T0789 PMSF 329-98-6 99.9%
PMSF
Phenylmethanesulfonyl fluoride (PMSF (Phenylmethylsulfonyl fluoride)) is an enzyme inhibitor that inactivates IRC-50 arvin, subtilisin, and the fatty acid synthe...
T5211 NSC 185058 39122-38-8 99.83%
NSC 185058
NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. It also can attenuate the autophagic activity.
T15641 K777 233277-99-1 99.71%
K777
K777 is a potent, orally active and irreversible inhibitor of cysteine protease. K777 is a potent CYP3A4 inhibitor (IC50= 60 nM). K777 is also a selective CCR4 a...
TJS2216 Aurantiamide acetate 56121-42-7 99.68%
Aurantiamide acetate
Aurantiamide acetate (Asperglaucide) was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate is a selectiv...
T6015 Cathepsin Inhibitor 1 225120-65-0 99.68%
Cathepsin Inhibitor 1
Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.
T6040 Aloxistatin 88321-09-9 99.47%
Aloxistatin
Aloxistatin (E64d) is an inhibitor of cysteine protease with blood platelet aggregation inhibiting activity. Aloxistatin is an irreversible, membrane-permeable i...
T60812 Cathepsin X-IN-1 2418577-51-0 99.46%
Cathepsin X-IN-1
Cathepsin X-IN-1 (compound 25) reduces the migration of PC-3 cell with low cytotoxic that is a potent inhibitor of Cathepsin X (IC 50 = 7.13 μM) [1].
T6738 Z-FA-FMK 197855-65-5 99.43%
Z-FA-FMK
Z-FA-FMK can irreversibly inhibit cysteine protease and also inhibit effector caspases.
ONO-5334
T16394
ONO-5334 is a selective, orally active and potent histone K inhibitor with anti-SAR-COV-2 and anti-bone resorption activity for the study of osteoporosis.
LV-320
T11896
LV-320 is a potent and uncompetitive ATG4B inhibitor with an IC 50 of 24.5 μM and a K d of 16 μM. LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flu...
GLPG2451
T13705
GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. It effectively potentiates low temperature rescued F508del CFTR (EC50: 11.1...
Cysteine protease inhibitor-2
T10924
Cysteine protease inhibitor 2 is a cysteine protease inhibitor. Cysteine protease inhibitor 2 inhibited DCT116 and PC3 cells with GI50 values of 6.5 μM and 4.4 μ...
LHVS
T11846
LHVS effectively blocks T. gondii microneme protein secretion (IC50=10 μM), gliding motility, and cell invasion. LHVS is a potent, non-selective cysteine proteas...
S130
T12819
S130 is a high affinity, selectiveATG4B (a major cysteine protease) inhibitor (IC50 of 3.24 μM).It suppresses autophagy flux.
(RS)-Butyryltimolol
T13439
(RS)-Butyryltimolol is the racemate of Butyryltimolol. Butyryltimolol is an effective prodrug of Timolol that improves the corneal penetration of Timolol [1]. Bu...
Cathepsin Inhibitor 2
T11554
Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor (Ki: <20 nM).
E-64
T6037
E-64 (Proteinase inhibitor E 64) is an irreversible and specific cysteine protease inhibitor. The IC50 of E-64 for papain is 9 nM.
Tacalcitol monohydrate
T13911
Tacalcitol monohydrate(Curatoderm monohydrate), a vitamin D3 analog that promotes bone development by regulating calcium ions, can be used to study psoriasis.
MK-0674
T16089
MK-0674 is an orally available, selective and potent cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S. It can be used in metabol...
3,4 Dichloroisocoumarin
T8677
3,4 Dichloroisocoumarin is a granzyme, cathepsin G, and neutrolphil elastase inhibitor
PMSF
T0789
Phenylmethanesulfonyl fluoride (PMSF (Phenylmethylsulfonyl fluoride)) is an enzyme inhibitor that inactivates IRC-50 arvin, subtilisin, and the fatty acid synthe...
NSC 185058
T5211
NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. It also can attenuate the autophagic activity.
K777
T15641
K777 is a potent, orally active and irreversible inhibitor of cysteine protease. K777 is a potent CYP3A4 inhibitor (IC50= 60 nM). K777 is also a selective CCR4 a...
Aurantiamide acetate
TJS2216
Aurantiamide acetate (Asperglaucide) was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate is a selectiv...
Cathepsin Inhibitor 1
T6015
Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.
Aloxistatin
T6040
Aloxistatin (E64d) is an inhibitor of cysteine protease with blood platelet aggregation inhibiting activity. Aloxistatin is an irreversible, membrane-permeable i...
Cathepsin X-IN-1
T60812
Cathepsin X-IN-1 (compound 25) reduces the migration of PC-3 cell with low cytotoxic that is a potent inhibitor of Cathepsin X (IC 50 = 7.13 μM) [1].
Z-FA-FMK
T6738
Z-FA-FMK can irreversibly inhibit cysteine protease and also inhibit effector caspases.
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TargetMol