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Cysteine Protease

Cysteine proteases, also known as thiol proteases, are enzymes that degrade proteins. These proteases share a common catalytic mechanism that involves a nucleophilic cysteine thiol in a catalytic triad or dyad.
Cat No. product name
T9710 Dazcapistat Dazcapistat 是一种有效的 calpain 抑制剂,对 calpain 1、calpain 2 和 calpain 9 的 IC50 值均 <3 μM。
T37504L Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base) Cathepsin D and E FRET Substrate acetate 是组织蛋白酶 D 和 E 的荧光底物,但不适用于 B、H 或 L。Cathepsin D and E FRET Substrate acetate 可用于组织蛋白酶 D 和 E 研究的机理研究。
T2470 MDL-28170 Calpain Inhibitor III is a Cysteine protease.
T20626 Esomeprazole Esomeprazole is the S-isomer of omeprazole, it is used in Gastro-oesophageal reflux disease (GORD).
T6040 Aloxistatin Aloxistatin is an inhibitor of cysteine protease with blood platelet aggregation inhibiting activity. Aloxistatin is an irreversible, membrane-permeable inhibito...
T8677 3,4 Dichloroisocoumarin 3,4 Dichloroisocoumarin is a granzyme, cathepsin G, and neutrolphil elastase inhibitor
T19503 Papain Papain is a cysteine protease of the peptidase C1 family. Papain is used in food, pharmaceutical, textile, and cosmetic industries.
T6738 Z-FA-FMK Z-FA-FMK can irreversibly inhibit cysteine protease and also inhibit effector caspases.
T3088 N-Ethylmaleimide N-ethylmaleimide is a sulfhydryl reagent that is widely used in experimental biochemical studies.
TJS2216 Aurantiamide acetate Aurantiamide acetate was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate is a selective and orally act...
T6583 MG-101 MG-101 (ALLN) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.
T6037 E-64 E-64 is an irreversible and specific cysteine protease inhibitor. The IC50 of E-64 for papain is 9 nM.
T2493 PD 151746 PD 151746 is a selective, cell-permeable calpain inhibitor (Ki: 0.26/5.33 μM, μ-Calpain/m-calpain).
TN1249 3-Epiursolic acid 3-Epiursolic acid may have antiinflammatory activity, it shows inhibition on Cathepsins L (catL), the IC50 value of 6.5 μM, cathepsins L (catL) and B play an imp...
T1080 2-Aminoethanethiol Cysteamine is a Cystine Depleting Agent. The mechanism of action of cysteamine is as a Cystine Disulfide Reduction.
T6432 Calpeptin Calpeptin is a potent, cell-permeable calpain inhibitor.
T27730 KGP94 KGP94 is an inhibitor of cysteine protease Cathepsin L(CTSL).
T6573 E 64c Loxistatin Acid (E-64C), a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.
T37753 Aureusimine B Aureusimine B, also known as phevalin, is a natural pyrazinone produced by certain fungi and by Staphylococcus spp., including S. aureus. Its synthesis appears t...
T21616 L-006235 L 006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM.
T1850 Balicatib Balicatib is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis.
T27695 JTE-607 JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.
T7451 2-Cyanopyrimidine 2-cyano-Pyrimidine is inhibitor of cathepsin K(IC50 : 170 nM)
T10924 Cysteine protease inhibitor-2 Cysteine protease inhibitor 2 is a cysteine protease inhibitor extracted from patent US20070032499A1, compound 12. Cysteine protease inhibitor 2 inhibited DCT116...
T0448 (S)-(+)-Ibuprofen Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
T0789 PMSF Phenylmethanesulfonyl fluoride (PMSF) is an enzyme inhibitor that inactivates IRC-50 arvin, subtilisin, and the fatty acid synthetase complex.
T12051 MIV-247 MIV-247 is a selective inhibitor of cathepsin S (human, mouse and cynomolgus monkey cathepsin S with Kis of 2.1, 4.2 and 7.5 nM , respectively).
T11896 LV-320 LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic and active in vivo. LV-320 is a potent and uncompetitive ATG4...
T11846 LHVS LHVS effectively blocks T. gondii microneme protein secretion (IC50=10 μM), gliding motility, and cell invasion. LHVS is a potent, non-selective cysteine proteas...
T11554 Cathepsin Inhibitor 2 Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor (Ki: <20 nM).
T12819 S130 S130 is a high affinity, selectiveATG4B (a major cysteine protease) inhibitor (IC50 of 3.24 µM).It suppresses autophagy flux.
T12909 SID 26681509 SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).
TQ0116 LY 3000328 LY 3000328 is a potent, highly selective Cathepsin S (Cat S) inhibitor (IC50s: 7.7 and 1.67 nM for hCat S and mCat S).
T3420 CA-074 methyl ester CA-074 methyl ester is a specific inhibitor of Cathepsin B with neuroprotective, anti-cancer, and anti-inflammatory effects.
T6015 Cathepsin Inhibitor 1 Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.
T6035 Odanacatib Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity.
T6564 Leupeptin Hemisulfate Leupeptin hemisulfate is a reversible, competitive serine/cysteine protease inhibitor. It is an orally active, antioxidant and anti-inflammatory agent.
T5211 NSC 185058 NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. It also can attenuate the autophagic activity.
T17026 Tecovirimat Tecovirimat is a core protein cysteine protease inhibitor potentially for treatment of smallpox infection.Tecovirimat is a novel antiviral potent and selective a...
T16106 ML224 ML224 is a selective TSHR inverse agonist. ML224 also inhibits TSH-stimulated cAMP production (IC50 = 2.3 μM).
T16394 ONO-5334 ONO-5334 is an effective and selective cathepsin K inhibitor (Ki: 0.10 nM, 0.049 nM, and 0.85 nM for human, rabbit, and rat cathepsin K, respectively). ONO-5334 ...
T16474 Petesicatib Petesicatib is an inhibitor of cathepsin S. Petesicatib used in the research of immune diseases.
T15641 K777 K777 is an orally active and irreversible cysteine protease inhibitor. K777 is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 is al...
T13439 (RS)-Butyryltimolol (RS)-Butyryltimolol is the racemate of Butyryltimolol. Butyryltimolol is a β-adrenergic blocker.
T13705 GLPG2451 GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. It effectively potentiates low temperature rescued F508del CFTR (EC50: 11.1...
Dazcapistat
T9710
Dazcapistat 是一种有效的 calpain 抑制剂,对 calpain 1、calpain 2 和 calpain 9 的 IC50 值均 <3 μM。
Cathepsin D and E FRET Substrate acetate(839730-93-7 Free base)
T37504L
MDL-28170
T2470
Calpain Inhibitor III is a Cysteine protease.
Esomeprazole
T20626
Esomeprazole is the S-isomer of omeprazole, it is used in Gastro-oesophageal reflux disease (GORD).
Aloxistatin
T6040
Aloxistatin is an inhibitor of cysteine protease with blood platelet aggregation inhibiting activity. Aloxistatin is an irreversible, membrane-permeable inhibito...
3,4 Dichloroisocoumarin
T8677
3,4 Dichloroisocoumarin is a granzyme, cathepsin G, and neutrolphil elastase inhibitor
Papain
T19503
Papain is a cysteine protease of the peptidase C1 family. Papain is used in food, pharmaceutical, textile, and cosmetic industries.
Z-FA-FMK
T6738
Z-FA-FMK can irreversibly inhibit cysteine protease and also inhibit effector caspases.
N-Ethylmaleimide
T3088
N-ethylmaleimide is a sulfhydryl reagent that is widely used in experimental biochemical studies.
Aurantiamide acetate
TJS2216
Aurantiamide acetate was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate is a selective and orally act...
MG-101
T6583
MG-101 (ALLN) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.
E-64
T6037
E-64 is an irreversible and specific cysteine protease inhibitor. The IC50 of E-64 for papain is 9 nM.
PD 151746
T2493
PD 151746 is a selective, cell-permeable calpain inhibitor (Ki: 0.26/5.33 μM, μ-Calpain/m-calpain).
3-Epiursolic acid
TN1249
3-Epiursolic acid may have antiinflammatory activity, it shows inhibition on Cathepsins L (catL), the IC50 value of 6.5 μM, cathepsins L (catL) and B play an im...
2-Aminoethanethiol
T1080
Cysteamine is a Cystine Depleting Agent. The mechanism of action of cysteamine is as a Cystine Disulfide Reduction.
Calpeptin
T6432
Calpeptin is a potent, cell-permeable calpain inhibitor.
KGP94
T27730
KGP94 is an inhibitor of cysteine protease Cathepsin L(CTSL).
E 64c
T6573
Loxistatin Acid (E-64C), a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.
Aureusimine B
T37753
Aureusimine B, also known as phevalin, is a natural pyrazinone produced by certain fungi and by Staphylococcus spp., including S. aureus. Its synthesis appears t...
L-006235
T21616
L 006235 is a potent and reversible inhibitor of cathepsin K with IC50 of 0.25 nM.
Balicatib
T1850
Balicatib is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis.
JTE-607
T27695
JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.
2-Cyanopyrimidine
T7451
2-cyano-Pyrimidine is inhibitor of cathepsin K(IC50 : 170 nM)
Cysteine protease inhibitor-2
T10924
Cysteine protease inhibitor 2 is a cysteine protease inhibitor extracted from patent US20070032499A1, compound 12. Cysteine protease inhibitor 2 inhibited DCT116...
(S)-(+)-Ibuprofen
T0448
Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
PMSF
T0789
Phenylmethanesulfonyl fluoride (PMSF) is an enzyme inhibitor that inactivates IRC-50 arvin, subtilisin, and the fatty acid synthetase complex.
MIV-247
T12051
MIV-247 is a selective inhibitor of cathepsin S (human, mouse and cynomolgus monkey cathepsin S with Kis of 2.1, 4.2 and 7.5 nM , respectively).
LV-320
T11896
LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic and active in vivo. LV-320 is a potent and uncompetitive ATG4...
LHVS
T11846
LHVS effectively blocks T. gondii microneme protein secretion (IC50=10 μM), gliding motility, and cell invasion. LHVS is a potent, non-selective cysteine protea...
Cathepsin Inhibitor 2
T11554
Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor (Ki: <20 nM).
S130
T12819
S130 is a high affinity, selectiveATG4B (a major cysteine protease) inhibitor (IC50 of 3.24 µM).It suppresses autophagy flux.
SID 26681509
T12909
SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).
LY 3000328
TQ0116
LY 3000328 is a potent, highly selective Cathepsin S (Cat S) inhibitor (IC50s: 7.7 and 1.67 nM for hCat S and mCat S).
CA-074 methyl ester
T3420
CA-074 methyl ester is a specific inhibitor of Cathepsin B with neuroprotective, anti-cancer, and anti-inflammatory effects.
Cathepsin Inhibitor 1
T6015
Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.
Odanacatib
T6035
Odanacatib is an inhibitor of cathepsin K with potential anti-osteoporotic activity.
Leupeptin Hemisulfate
T6564
Leupeptin hemisulfate is a reversible, competitive serine/cysteine protease inhibitor. It is an orally active, antioxidant and anti-inflammatory agent.
NSC 185058
T5211
NSC 185058 is an inhibitor of ATG4B, a major cysteine protease. It also can attenuate the autophagic activity.
Tecovirimat
T17026
Tecovirimat is a core protein cysteine protease inhibitor potentially for treatment of smallpox infection.Tecovirimat is a novel antiviral potent and selective a...
ML224
T16106
ML224 is a selective TSHR inverse agonist. ML224 also inhibits TSH-stimulated cAMP production (IC50 = 2.3 μM).
ONO-5334
T16394
ONO-5334 is an effective and selective cathepsin K inhibitor (Ki: 0.10 nM, 0.049 nM, and 0.85 nM for human, rabbit, and rat cathepsin K, respectively). ONO-5334 ...
Petesicatib
T16474
Petesicatib is an inhibitor of cathepsin S. Petesicatib used in the research of immune diseases.
K777
T15641
K777 is an orally active and irreversible cysteine protease inhibitor. K777 is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 is al...
(RS)-Butyryltimolol
T13439
(RS)-Butyryltimolol is the racemate of Butyryltimolol. Butyryltimolol is a β-adrenergic blocker.
GLPG2451
T13705
GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. It effectively potentiates low temperature rescued F508del CFTR (EC50: 11.1...