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Cysteine Protease

Cysteine proteases, also known as thiol proteases, are enzymes that degrade proteins. These proteases share a common catalytic mechanism that involves a nucleophilic cysteine thiol in a catalytic triad or dyad.
Cat. No. Product name CAS No. Purity Chemical Structure
T10924 Cysteine protease inhibitor-2 612048-23-4 98%
Cysteine protease inhibitor 2 is a cysteine protease inhibitor extracted from patent US20070032499A1, compound 12. Cysteine protease inhibitor 2 inhibited DCT116...
T11554 Cathepsin Inhibitor 2 1017931-53-1 98%
Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor (Ki: <20 nM).
TJS2216 Aurantiamide acetate 56121-42-7 98%
Aurantiamide acetate was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate is a selective and orally act...
T16106 ML224 1338824-21-7 98%
ML224 is a selective TSHR inverse agonist. ML224 also inhibits TSH-stimulated cAMP production (IC50 = 2.3 μM).
T12819 S130 1160852-22-1 98%
S130 is a high affinity, selectiveATG4B (a major cysteine protease) inhibitor (IC50 of 3.24 µM).It suppresses autophagy flux.
T13705 GLPG2451 2055015-61-5 98%
GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. It effectively potentiates low temperature rescued F508del CFTR (EC50: 11.1...
T12051 MIV-247 1352817-76-5 98%
MIV-247 is a selective inhibitor of cathepsin S (human, mouse and cynomolgus monkey cathepsin S with Kis of 2.1, 4.2 and 7.5 nM , respectively).
T11846 LHVS 170111-28-1 98%
LHVS effectively blocks T. gondii microneme protein secretion (IC50=10 μM), gliding motility, and cell invasion. LHVS is a potent, non-selective cysteine proteas...
T13439 (RS)-Butyryltimolol 2320274-78-8 98%
(RS)-Butyryltimolol is the racemate of Butyryltimolol. Butyryltimolol, an effective prodrug of Timolol, improves the corneal penetration of Timolol [1]. Butyrylt...
T11896 LV-320 2449093-46-1 98%
LV-320 is a potent and uncompetitive ATG4B inhibitor with an IC 50 of 24.5 μM and a K d of 16 μM. LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flu...
T60812 Cathepsin X-IN-1 2418577-51-0 98%
Cathepsin X-IN-1 (compound 25) is a potent Cathepsin X inhibitor (IC50= 7.13 µM). Cathepsin X-IN-1 shows inhibition effect to PC-3 cell migration with low cytoto...
T16394 ONO-5334 868273-90-9 98%
ONO-5334 is an effective and selective cathepsin K inhibitor (Ki: 0.10 nM, 0.049 nM, and 0.85 nM for human, rabbit, and rat cathepsin K, respectively). ONO-5334 ...
T16474 Petesicatib 1252637-35-6 98%
Petesicatib is an inhibitor of cathepsin S. Petesicatib used in the research of immune diseases.
TP2056L Acetyl-Calpastatin (184-210)(human) acetate 98%
Acetyl-Calpastatin (184-210)(human) acetate is a potent, selective and reversible calpain inhibitor with Ki values of 0.2 nM and 6 μM for µ-calpain and cathepsin...
T13288 VBY-825 1310340-58-9 98%
VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.
T60150 (1S,2R)-Alicapistat 2221010-57-5 98%
(1S,2R)-Alicapistat ((1S,2R)-ABT-957) is an orally active selective inhibitor of human calpains 1 and 2 for the potential application of Alzheimer's disease (AD)...
T37753 Aureusimine B 170713-71-0 98%
Aureusimine B, also known as phevalin, is a natural pyrazinone produced by certain fungi and by Staphylococcus spp., including S. aureus. Its synthesis appears t...
T27695 JTE-607 188791-09-5
JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.
T19503 Papain 9001-73-4
Papain is a cysteine protease of the peptidase C1 family. Papain is used in food, pharmaceutical, textile, and cosmetic industries.
T2470 MDL-28170 88191-84-8
Calpain Inhibitor III is a Cysteine protease.
Cysteine protease inhibitor-2
T10924
Cysteine protease inhibitor 2 is a cysteine protease inhibitor extracted from patent US20070032499A1, compound 12. Cysteine protease inhibitor 2 inhibited DCT116...
Cathepsin Inhibitor 2
T11554
Cathepsin Inhibitor 2 is a potent Cathepsin S inhibitor (Ki: <20 nM).
Aurantiamide acetate
TJS2216
Aurantiamide acetate was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate is a selective and orally act...
ML224
T16106
ML224 is a selective TSHR inverse agonist. ML224 also inhibits TSH-stimulated cAMP production (IC50 = 2.3 μM).
S130
T12819
S130 is a high affinity, selectiveATG4B (a major cysteine protease) inhibitor (IC50 of 3.24 µM).It suppresses autophagy flux.
GLPG2451
T13705
GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. It effectively potentiates low temperature rescued F508del CFTR (EC50: 11.1...
MIV-247
T12051
MIV-247 is a selective inhibitor of cathepsin S (human, mouse and cynomolgus monkey cathepsin S with Kis of 2.1, 4.2 and 7.5 nM , respectively).
LHVS
T11846
LHVS effectively blocks T. gondii microneme protein secretion (IC50=10 μM), gliding motility, and cell invasion. LHVS is a potent, non-selective cysteine proteas...
(RS)-Butyryltimolol
T13439
(RS)-Butyryltimolol is the racemate of Butyryltimolol. Butyryltimolol, an effective prodrug of Timolol, improves the corneal penetration of Timolol [1]. Butyrylt...
LV-320
T11896
LV-320 is a potent and uncompetitive ATG4B inhibitor with an IC 50 of 24.5 μM and a K d of 16 μM. LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flu...
Cathepsin X-IN-1
T60812
Cathepsin X-IN-1 (compound 25) is a potent Cathepsin X inhibitor (IC50= 7.13 µM). Cathepsin X-IN-1 shows inhibition effect to PC-3 cell migration with low cytoto...
ONO-5334
T16394
ONO-5334 is an effective and selective cathepsin K inhibitor (Ki: 0.10 nM, 0.049 nM, and 0.85 nM for human, rabbit, and rat cathepsin K, respectively). ONO-5334 ...
Petesicatib
T16474
Petesicatib is an inhibitor of cathepsin S. Petesicatib used in the research of immune diseases.
Acetyl-Calpastatin (184-210)(human) acetate
TP2056L
Acetyl-Calpastatin (184-210)(human) acetate is a potent, selective and reversible calpain inhibitor with Ki values of 0.2 nM and 6 μM for µ-calpain and cathepsin...
VBY-825
T13288
VBY-825 is a reversible inhibitor of cathepsin with high potency against cathepsins B, L, S and V.
(1S,2R)-Alicapistat
T60150
(1S,2R)-Alicapistat ((1S,2R)-ABT-957) is an orally active selective inhibitor of human calpains 1 and 2 for the potential application of Alzheimer's disease (AD)...
Aureusimine B
T37753
Aureusimine B, also known as phevalin, is a natural pyrazinone produced by certain fungi and by Staphylococcus spp., including S. aureus. Its synthesis appears t...
JTE-607
T27695
JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.
Papain
T19503
Papain is a cysteine protease of the peptidase C1 family. Papain is used in food, pharmaceutical, textile, and cosmetic industries.
MDL-28170
T2470
Calpain Inhibitor III is a Cysteine protease.
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