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Beta Amyloid

Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. The peptides derive from the amyloid precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ. Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. It is now believed that certain misfolded oligomers (known as "seeds") can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TP1007 β-Amyloid (1-42), human 107761-42-2 99.52%
β-Amyloid (1-42), human
Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.
TN1798 Isorosmanol 93780-80-4 98.85%
Isorosmanol
Isorosmanol possesses antioxidant, neuroprotective and neurotrophic effects, it might be useful in ageing disorders such as the declining of cognitive functions ...
T19011 Hoechst 34580 23555-00-2 98.84%
Hoechst 34580
Hoechst 34580 (HOE 34580), a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
T14525 Begacestat 769169-27-9 98%
Begacestat
Begacestat is a selective thiophene sulfonamide amyloid precursor protein gamma-secretase inhibitor (Aβ40,IC50=15 nM),and for the treatment of Alzheimer's diseas...
TN3410 Anatabine 581-49-7 98%
Anatabine
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
TN1653 Fustin 20725-03-5 98%
Fustin
Fustin is the phytogenic flavanol component of the plant Rhus verniciflua Stokes. Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell deat...
TN1919 (+)-Medioresinol 40957-99-1 98%
(+)-Medioresinol
Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in th...
TN4865 Putraflavone 23624-21-7 98%
Putraflavone
Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
TN3618 Cedrin 75513-81-4 98%
Cedrin
Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative s...
T6562 Latrepirdine dihydrochloride 97657-92-6 98%
Latrepirdine dihydrochloride
Latrepirdine dihydrochloride (Dimebolin dihydrochloride) is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors,...
TN4571 Mirabijalone D 485811-84-5 98%
Mirabijalone D
Mirabijalone D is a non-competitive inhibitor based on the Dixon plot.It inhibits Aβ1-42 production by 43.7% in APPSW-N2a cells.
T19013 Hoechst 34580 tetrahydrochloride T19013 98%
Hoechst 34580 tetrahydrochloride
Hoechst 34580 tetrahydrochloride, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
T10453 BACE1-IN-5 2581114-83-0 98%
BACE1-IN-5
BACE1-IN-5 (Compound 15) is a β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC 50 of 9.1 nM. BACE1-IN-5 also inhibits cellular amy...
T19142 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine 566169-98-0 98%
4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine
4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).
T5810 TABERSONINE HYDROCHLORIDE 29479-00-3 98%
TABERSONINE HYDROCHLORIDE
TABERSONINE HYDROCHLORIDE is a natural product extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1 42) aggregation and toxicity.
TN3218 7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one 100667-52-5 98%
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may...
TN4635 Neoechinulin A 51551-29-2 98%
Neoechinulin A
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the ...
T4398 LX2343 333745-53-2 99.92%
LX2343
LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343...
T4S0350 Licochalcone B 58749-23-8 99.9%
Licochalcone B
1. Licochalcone B (LCB) inhibits the proliferation of human malignant bladder cancer cell lines (T24 and EJ) in vitro and antitumor activity in vivo in MB49 (mur...
T60671 MAO-B-IN-9 2416910-88-6 99.88%
MAO-B-IN-9
MAO-B-IN-9 is a monoamine oxidase B MAO-B inhibitor (IC50: 0.18 μM) that crosses the blood-brain barrier with potency, selectivity and time-dependence. MAO-B-IN-...
β-Amyloid (1-42), human
TP1007
Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.
Isorosmanol
TN1798
Isorosmanol possesses antioxidant, neuroprotective and neurotrophic effects, it might be useful in ageing disorders such as the declining of cognitive functions ...
Hoechst 34580
T19011
Hoechst 34580 (HOE 34580), a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
Begacestat
T14525
Begacestat is a selective thiophene sulfonamide amyloid precursor protein gamma-secretase inhibitor (Aβ40,IC50=15 nM),and for the treatment of Alzheimer's diseas...
Anatabine
TN3410
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
Fustin
TN1653
Fustin is the phytogenic flavanol component of the plant Rhus verniciflua Stokes. Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell deat...
(+)-Medioresinol
TN1919
Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in th...
Putraflavone
TN4865
Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
Cedrin
TN3618
Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative s...
Latrepirdine dihydrochloride
T6562
Latrepirdine dihydrochloride (Dimebolin dihydrochloride) is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors,...
Mirabijalone D
TN4571
Mirabijalone D is a non-competitive inhibitor based on the Dixon plot.It inhibits Aβ1-42 production by 43.7% in APPSW-N2a cells.
Hoechst 34580 tetrahydrochloride
T19013
Hoechst 34580 tetrahydrochloride, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
BACE1-IN-5
T10453
BACE1-IN-5 (Compound 15) is a β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC 50 of 9.1 nM. BACE1-IN-5 also inhibits cellular amy...
4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine
T19142
4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).
TABERSONINE HYDROCHLORIDE
T5810
TABERSONINE HYDROCHLORIDE is a natural product extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1 42) aggregation and toxicity.
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one
TN3218
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may...
Neoechinulin A
TN4635
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the ...
LX2343
T4398
LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343...
Licochalcone B
T4S0350
1. Licochalcone B (LCB) inhibits the proliferation of human malignant bladder cancer cell lines (T24 and EJ) in vitro and antitumor activity in vivo in MB49 (mur...
MAO-B-IN-9
T60671
MAO-B-IN-9 is a monoamine oxidase B MAO-B inhibitor (IC50: 0.18 μM) that crosses the blood-brain barrier with potency, selectivity and time-dependence. MAO-B-IN-...
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TargetMol