Beta Amyloid

Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. The peptides derive from the amyloid precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ. Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. It is now believed that certain misfolded oligomers (known as "seeds") can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection.

Cat. No.	Product name	CAS No.	Purity
TN4635	Neoechinulin A	51551-29-2	98%
TN4635	Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-ÎºB and p38 MAPK pathways, it may block the ...
TN3218	7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one	100667-52-5	98%
TN3218	7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may...
T19142	4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine	566169-98-0	98%
T19142	4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).
T10453	BACE1-IN-5	2581114-83-0	98%
T10453	BACE1-IN-5 (Compound 15) is a β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC 50 of 9.1 nM. BACE1-IN-5 also inhibits cellular amy...
T19013	Hoechst 34580 tetrahydrochloride	T19013	98%
T19013	Hoechst 34580 tetrahydrochloride, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
TN4571	Mirabijalone D	485811-84-5	98%
TN4571	Mirabijalone D is a non-competitive inhibitor based on the Dixon plot.It inhibits Aβ1-42 production by 43.7% in APPSW-N2a cells.
T6562	Latrepirdine dihydrochloride	97657-92-6	98%
T6562	Latrepirdine is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihi...
TN3618	Cedrin	75513-81-4	98%
TN3618	Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative s...
TN4865	Putraflavone	23624-21-7	98%
TN4865	Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
TN1919	(+)-Medioresinol	40957-99-1	98%
TN1919	Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in th...
TN3410	Anatabine	581-49-7	98%
TN3410	Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
T14525	Begacestat	769169-27-9	98%
T14525	Begacestat is a selective thiophene sulfonamide amyloid precursor protein gamma-secretase inhibitor (Aβ40,IC50=15 nM),and for the treatment of Alzheimer's diseas...
TN1216	2-O-Acetyl-20-hydroxyecdysone	19536-25-5	98%
TN1216	2-O-Acetyl-20-hydroxyecdysone is an ecdysone present in insects and terrestrial plants. 2-O-Acetyl-20-hydroxyecdysone inhibits amyloid-β42-induced cytotoxicity a...
T22932L	LPYFD-NH2 acetate		98%
T22932L	LPYFD-NH2 acetate shows some inhibitory effect on the aggregation of Abeta(1-42).
TQ0026	MDR-1339	1018946-38-7	98%
TQ0026	MDR-1339 (DWK-1339) is an orally active and blood-brain-barrier-permeable inhibitor of amyloid-β (Aβ) aggregation.
TP1935L1	RAGE antagonist peptide acetate	TP1935L1	98%
TP1935L1	RAGE antagonist peptide acetate is an advanced antagonist of glycation end products (RAGE). RAGE antagonist peptide acetate possesses anti-tumor and anti-inflamm...
T14673	BMS 299897	290315-45-6	98%
T14673	BMS 299897 is a sulfonamide γ-secretase inhibitor. It has an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor pr...
T5810	TABERSONINE HYDROCHLORIDE	29479-00-3	98%
T5810	TABERSONINE HYDROCHLORIDE is a natural product extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1 42) aggregation and toxicity.
T7905	PBD-150	790663-33-1	98%
T7905	PBD-150 is an inhibitor of human glutaminyl cyclase (hQC) Y115E-Y117E variant( ki : 490 nM)
T14284	β-Amyloid (25-35)	131602-53-4	98%
T14284	Amyloid beta-peptide(25-35) is the fragment Aβ(25-35) of the Alzheimer's amyloid β-peptide. Which has shown neurotoxic activities in cultured cells.