Home Tools

Beta Amyloid

Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of people with Alzheimer's disease. The peptides derive from the amyloid precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ. Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. It is now believed that certain misfolded oligomers (known as "seeds") can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
TP1007 β-Amyloid (1-42), human 107761-42-2 99.52%
β-Amyloid (1-42), human
β-Amyloid (1-42), human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.
TN1798 Isorosmanol 93780-80-4 98.85%
Isorosmanol
Isorosmanol possesses antioxidant, neuroprotective and neurotrophic effects, it might be useful in ageing disorders such as the declining of cognitive functions ...
T19011 Hoechst 34580 23555-00-2 98.84%
Hoechst 34580
Hoechst 34580 (HOE 34580), a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
T14525 Begacestat 769169-27-9 98%
Begacestat
Begacestat is a selective thiophene sulfonamide amyloid precursor protein gamma-secretase inhibitor (Aβ40,IC50=15 nM),and for the treatment of Alzheimer's diseas...
T80622 Trontinemab 2568868-35-7 98%
Trontinemab
Trontinemab (RG6102) is a human IgG1-κ antibody selectively targeting Aβ precursor protein (APP) with transferrin receptor p90, CD71 (TFRC), inhibits amyloid pro...
TN3410 Anatabine 581-49-7 98%
Anatabine
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
TN1653 Fustin 20725-03-5 98%
Fustin
Fustin is the phytogenic flavanol component of the plant Rhus verniciflua Stokes. Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell deat...
TN1919 (+)-Medioresinol 40957-99-1 98%
(+)-Medioresinol
Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in th...
TN4865 Putraflavone 23624-21-7 98%
Putraflavone
Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
T37456 C18 L-erythro Ceramide (d18:1/18:0) 252039-52-4 98%
C18 L-erythro Ceramide (d18:1/18:0)
C18 L-erythro Ceramide (d18:1/18:0) significantly reduced extracellular Aβ levels and can be used to study Alzheimer's disease.
TN3618 Cedrin 75513-81-4 98%
Cedrin
Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative s...
TN4571 Mirabijalone D 485811-84-5 98%
Mirabijalone D
Mirabijalone D is a non-competitive inhibitor based on the Dixon plot.It inhibits Aβ1-42 production by 43.7% in APPSW-N2a cells.
T19013 Hoechst 34580 tetrahydrochloride 98%
Hoechst 34580 tetrahydrochloride
Hoechst 34580 tetrahydrochloride, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
T38789 BMS-984923 1375752-78-5 98%
BMS-984923
BMS-984923 is an orally available and blood-brain barrier permeable mGluR5 silencing allosteric modulator that inhibits β-amyloid oligomer-induced aberrant synap...
T10453 BACE1-IN-5 2581114-83-0 98%
BACE1-IN-5
BACE1-IN-5 (Compound 15), a potent β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, demonstrates significant efficacy with an IC50 of 9.1 nM...
T19142 4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine 566169-98-0 98%
4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine
4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).
TN3218 7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one 100667-52-5 98%
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may...
TN4635 Neoechinulin A 51551-29-2 98%
Neoechinulin A
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the ...
T77042 Aducanumab 1384260-65-4 SDS-PAGE:97.3%;SEC-HPLC:97.1%
Aducanumab
Aducanumab (BIIB037), A selective human immunoglobulin gamma-1 (IgG1) monoclonal antibody, targets the clustered form of amyloid beta (Aβ). Aducanumab shows brai...
T7003 Leucomethylene blue mesylate 1236208-20-0 99.99%
Leucomethylene blue mesylate
Leucomethylene blue mesylate (TRx0237 mesylate) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and fronto...
β-Amyloid (1-42), human
TP1007
β-Amyloid (1-42), human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.
Isorosmanol
TN1798
Isorosmanol possesses antioxidant, neuroprotective and neurotrophic effects, it might be useful in ageing disorders such as the declining of cognitive functions ...
Hoechst 34580
T19011
Hoechst 34580 (HOE 34580), a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
Begacestat
T14525
Begacestat is a selective thiophene sulfonamide amyloid precursor protein gamma-secretase inhibitor (Aβ40,IC50=15 nM),and for the treatment of Alzheimer's diseas...
Trontinemab
T80622
Trontinemab (RG6102) is a human IgG1-κ antibody selectively targeting Aβ precursor protein (APP) with transferrin receptor p90, CD71 (TFRC), inhibits amyloid pro...
Anatabine
TN3410
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheime...
Fustin
TN1653
Fustin is the phytogenic flavanol component of the plant Rhus verniciflua Stokes. Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell deat...
(+)-Medioresinol
TN1919
Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in th...
Putraflavone
TN4865
Putraflavone possesses a good antioxidant activity via its DPPH free radical scavenging.
C18 L-erythro Ceramide (d18:1/18:0)
T37456
C18 L-erythro Ceramide (d18:1/18:0) significantly reduced extracellular Aβ levels and can be used to study Alzheimer's disease.
Cedrin
TN3618
Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative s...
Mirabijalone D
TN4571
Mirabijalone D is a non-competitive inhibitor based on the Dixon plot.It inhibits Aβ1-42 production by 43.7% in APPSW-N2a cells.
Hoechst 34580 tetrahydrochloride
T19013
Hoechst 34580 tetrahydrochloride, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
BMS-984923
T38789
BMS-984923 is an orally available and blood-brain barrier permeable mGluR5 silencing allosteric modulator that inhibits β-amyloid oligomer-induced aberrant synap...
BACE1-IN-5
T10453
BACE1-IN-5 (Compound 15), a potent β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, demonstrates significant efficacy with an IC50 of 9.1 nM...
4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine
T19142
4-(6-Bromo-2-benzothiazolyl)-N-methylbenzenamine is a potent amyloid imaging agent that binds to Amyloid-β (1-40) (KD: 1.7 nM).
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one
TN3218
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and may...
Neoechinulin A
TN4635
Neoechinulin A has anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, it may block the ...
Aducanumab
T77042
Aducanumab (BIIB037), A selective human immunoglobulin gamma-1 (IgG1) monoclonal antibody, targets the clustered form of amyloid beta (Aβ). Aducanumab shows brai...
Leucomethylene blue mesylate
T7003
Leucomethylene blue mesylate (TRx0237 mesylate) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and fronto...
1 2 3 4 5 6
TargetMol