triterpenoid

Ilexgenin A is a novel pentacyclic triterpenoid, is a compound extracted from leaves of Ilex hainanensis Merr

Rosamultin has antioxidant, antiinflammatory/antinociceptive properties,and has anti-human immunodeficiency virus (HIV) activity.

1. Ganoderic acid D is one of the major components in Ganoderma triterpenes. 2. Ganoderic acid D treatment for 48h inhibits the proliferation of HeLa human cervical carcinoma cells with an IC(5) value of 17.3 +/- .3 microM.

3-O-Acetyl-16α-hydroxydehydrotrametenolic acid (3-O-Acetyl-16 alpha-hydroxydehydrotrametenolic acid) exhibits anti-inflammatory activity by inhibiting NO production and iNOS expression in LPS-stimulated Raw264.7 cells.

Terminolic acid (2α,6β,23-trihydroxyl oleanolic acid) is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum, can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL-1β and IL-6, and enhance anti-inflammatory cytokines by binding to IL-4 receptor binding sites. It also exhibits moderate antibacterial activity.

Omaveloxolone (RTA-408) (RTA-408) is a synthetic triterpenoid that activates the cytoprotective transcription factor Nrf2 and inhibits NF-κB signaling. Phase 2.

Limonin (Citrolimonin) is a triterpenoid enriched in citrus fruits, which has antivirus and antitumor ability.

Glycyrrhizic acid (Glycyrrhizin), the active ingredient in licorice, is a triterpene saponins and an antagonist of HMGB1. Glycyrrhizic acid has the potential to be used in cancer, diabetes and other research.

Hederagenin (Hederagenol) is a triterpenoid saponin inhibiting LPS-stimulated expression of iNOS, COX-2, and NF-κB.

Astramembrangenin (Cycloastragenol (Astramembrangenin)) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus. Cycloastragenol (CAG) may have a novel therapeutic role in depression

Bardoxolone Methyl (TP-155) is a synthetic triterpenoid that acts as an activator of the Nrf2 pathway and an inhibitor of the NF-κB pathway with potential anti-tumor and anti-inflammatory activities.

beta-Escin is a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent.

3α-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle, acting as a potent activator of AMPK and enhancing AMPK phosphorylation.

Mogroside I A1, a triterpenoid glycoside isolated from extracts of Luo Han Guo, exhibits antioxidant, antidiabetic, and anticancer activities.

Mogroside I E1, a triterpenoid glycoside isolated from the extracts of Luo Han Guo, acts as a nonsugar sweetener.

Quadranoside III is a triterpenoid compound isolated from the dried stems and leaves of Melissa officinalis with potential antibacterial and antioxidant activities.

3-Oxo-21α-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone is a cytotoxic tirucallane C26 triterpenoid that has been extracted from the stem barks of Aphanamixis grandifolia.

CDDO-dhTFEA, a synthetic oleanane triterpenoid, effectively activates Nrf2 while inhibiting the NF-κB pro-inflammatory transcription factor. It restores mean arterial pressure (MAP), elevates Nrf2 levels and the expression of related genes, attenuates NF-κB and transforming growth factor-β pathway activation, and mitigates glomerulosclerosis, interstitial fibrosis, and inflammation in rats with chronic kidney disease (CKD).

Dehydroeburicoic acid monoacetate (3-O-Acetyldehydroeburicoic acid) is a triterpenoid of lanolin isolated from Wolfiporia cocos.

Siraitic Acid A is a natural product(cucurbitane triterpenoid) isolated from the root of S. grosvenori .

Siraitic Acid B is a natural product(cucurbitane triterpenoid) isolated from the root of S. grosvenori .

Cauloside C is a natural triterpenoid glycoside with anti-inflammatory activity, inhibiting iNOS and pro-inflammatory cytokines (e.g., TNF-α, IL-1β, IL-6, COX-2).

Bryonolic acid (20-epi-Bryonolic acid), a triterpenoid extracted from Sandoricum indicum, possesses immunomodulatory, anti-inflammatory, antioxidant and anticancer activities and protects PC12 cells from NMDA-induced apoptosis by inhibiting Ca2+ in-flux and modulating gene expression in the Ca2+-CaMKII-CREB signalling pathway.

28-Aminobetulin is a pentacyclic triterpenoid compound and a derivative of Betulin, which acts as an inhibitor of cholesterol biosynthesis.