thaliana

Glucosinalbate is a natural product isolated from Arabidopsis thaliana.

Scopolin (Scopoloside) formation is increased by the enhanced activity of PAL. Scopolin can reduce the clinical symptoms of rat AIA by inhibiting inflammation and angiogenesis, and this compound may be a potent agent for angiogenesis related diseases and can serve as a structural base for screening more potent synthetic analogs.

Thermospermine is a structural isomer of spermine that plays a role in inhibiting xylem differentiation and can enhance the translation of SAC51 and SACL1 in Arabidopsis thaliana. Thermospermine is also used in studies as a plant growth regulator and for controlling wood biomass production.

16-hydroxy Hexadecanoic Acid (Juniperic acid) is a compound isolated from the leaves and stems of Arabidopsis thaliana and can be used to prevent, alleviate, or treat metabolic diseases.

DL-m-Tyrosine is a non-proteinogenic amino acid. It inhibits microbial proliferation and spore formation, and significantly suppresses root development of lettuce, Arabidopsis thaliana and other plants. Combined with carbidopa, it exerts significant antihypertensive pharmacological activity and can be used as a research tool in the development and mechanism exploration of biopesticides.

Karrikin 2 is a seed germination stimulant. It enhances the expression of gibberellin (GA) biosynthesis genes GA3ox1 and GA3ox2, as well as the GA4-responsive gene CP1, in A. thaliana.

D-Psicose (D-Allulose) is an orally active rare sugar. It effectively inhibits p38-MAPK phosphorylation and MCP-1 expression, while blocking the AGEs/RAGE/NF-kappaB signaling pathway. D-Psicose demonstrates significant bioactivity in research involving pancreatic beta-islet protection, hyperglycemia improvement, lipid metabolism regulation, and the mitigation of high-fat diet-induced non-alcoholic fatty liver disease (NAFLD).

DHAD-IN-1 (Compound I-6e) is a potent inhibitor of dihydroxy acid dehydratase (DHAD), exhibiting a Ki value of 1 μM against Arabidopsis thaliana DHAD. It demonstrates 100% efficacy in controlling weeds such as oats and foxtail. DHAD-IN-1 is a promising candidate for herbicide research.

HPPD/PPO-IN-1 (Compound B14) functions as a dual inhibitor of both HPPD and PPO, exhibiting IC50 values of 0.12 μM for Arabidopsis thaliana HPPD and 0.51 μM for Nicotiana tabacum PPO. This compound demonstrates broad-spectrum herbicidal activity while being safe for use on peanut and cotton crops. HPPD/PPO-IN-1 is suitable for the development of environmentally friendly herbicides.

Flusulfinam is an HPPD inhibitor and herbicide (Herbicide) with an IC50 of 0.0181 μM for Arabidopsis thaliana HPPD. It inhibits the catalytic activity of recombinant Arabidopsis thaliana HPPD and demonstrates strong herbicidal activity against barnyard grass (Echinochloa crus-galli). Additionally, Flusulfinam suppresses the growth of crabgrass (Digitaria sanguinalis).

Quinabactin(LC-66C6) is a potent sulfonamide abscisic acid ABA agonist.Quinabactin promotes guard cell closure, inhibits water loss, suppresses seed germination, and improves drought tolerance in adult Arabidopsis thaliana and soybean plants.

Tiafenacil is a novel herbicide that inhibits protoporphyrinogen IX oxidase (PPO), exhibiting IC50 values ranging from 22 to 28 nM across different plant species such as amaranth (Amaranthus tuberculatus), soybean (Glycine max), arabidopsis (Arabidopsis thaliana), and rapeseed (Brassica napus)[1].

AAL1 is an inhibitor of dark-grown Arabidopsis thaliana seedlings, functioning through auxin receptor Transport Inhibitor Response1 (TIR1) and depending on auxin influx and efflux carriers.

HPPD-IN-1 (compound II-3), a potent HPPD inhibitor, exhibits inhibitory activity against Arabidopsis thaliana HPPD (AtHPPD) with an IC50 of 0.248 μM, surpassing mesotrione's IC50 of 0.283 μM, and demonstrates excellent herbicidal efficacy against both broadleaf and monocotyledonous weeds [1].

Fenquinotrione, a 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitor, exhibits IC50 values of 27.2 and 44.7 nM against HPPD from rice and Arabidopsis thaliana, respectively. As an herbicide, it effectively controls a wide spectrum of broadleaf and sedge weeds while demonstrating notable selectivity for rice [1].

Farnesylcysteine (FC) serves as a competitive inhibitor of ICMT and is associated with an ABA hypersensitive phenotype in Arabidopsis thaliana. The fcly mutant exhibits reduced farnesylcysteine (FC) lyase activity and shows an increased response to ABA [1].

Chromosaponin I (Soyasaponin βg) is a triterpenoid saponin that can be isolated from peas. It has the ability to stimulate root growth in Arabidopsis thaliana seedlings.

Acyl-CoA oxidase (ACX) is a well-defined enzymatic protein that catalyzes the oxidation of fatty acyl-CoA substrates to 2-trans-enoyl-CoA intermediates, serving as a rate-limiting and essential step in the biosynthesis of jasmonic acid (JA), Acyl-CoA oxidase is particularly significant in model organisms such as Arabidopsis thaliana, Acyl-CoA oxidase contributes to lipid metabolism, stress signaling pathways, and the regulation of plant growth and defense responses.

L-galactono-1,4-lactone dehydrogenase (GALDH) catalyzes the terminal step of vitamin C biosynthesis within plant mitochondria. L-galactono-1,4-lactone dehydrogenase (GALDH) has been employed to investigate the molecular communication between Arabidopsis thaliana L-galactono-1,4-lactone dehydrogenase (GALDH) and its natural electron acceptor cytochrome c (Cc). Experimental evidence indicates that cytochrome c utilizes a conserved surface surrounding the heme edge for interactions with L-galactono-1,4-lactone dehydrogenase (GALDH) and additional redox partners. These findings support the use of L-galactono-1,4-lactone dehydrogenase (GALDH) in studies of mitochondrial electron transfer, redox biology, and plant metabolic regulation.

Plant 14-3-3-IN-1 (Compound 2) is an inhibitor of the Arabidopsis thaliana 14-3-3 protein, with an IC50 of 1.21 μM. It exhibits varying inhibitory activity against different 14-3-3 isoforms and promotes the closure of leaf stomata.