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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T74885 | RNA splicing modulator 2 | ||
RNA splicing modulator 2 (compound 256) is a RNA splicing modulator [1] . | |||
T74886 | RNA splicing modulator 3 | ||
RNA Splicing Modulator 3 (Compound 236) is an effective RNA splicing modulator, exhibiting an AC50 value of less than 100 nM [1]. | |||
T74884 | RNA splicing modulator 1 | ||
RNA Splicing Modulator 1 (Compound 233) is a modulator of RNA splicing, exhibiting an AC50 value of less than 100 nM [1]. | |||
T62612 | CD33 splicing modulator 1 | ||
CD33 splicing modulator 1 (Compound 1) is a CD33 splicing modulator. CD33/Siglec 3 is a myeloid cell surface receptor known to regulate microglial cell activity. CD33 splicing modulator 1 has potential for the study of n... | |||
T82763 | CD33 splicing modulator 1 hydrochloride | ||
CD33 Splicing Modulator 1 Hydrochloride (Compound 1) is a myeloid lineage cell surface receptor CD33/Siglec 3 modulator involved in regulating microglia activity. This compound promotes exon 2 skipping in cellular mRNA p... | |||
T4641 | Branaplam | LMI 070,NVS-SM1 | Others , Potassium Channel , DNA/RNA Synthesis |
Branaplam (LMI 070) is a highly potent, selective and orally active small molecule SMN2 splicing modulator. | |||
T9854 | HIV-1 inhibitor-6 | 3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo- | HIV Protease |
HIV-1 inhibitor-6 (3-Pyridinecarboxamide, 1,4-dihydro-1-methyl-N-(5-nitro-1,2-benzisothiazol-3-yl)-4-oxo-) is a potent HIV-1 pre-mRNA selective splicing inhibitor that blocks HIV replication. | |||
T73475 | SMN-C2 | DNA/RNA Synthesis | |
SMN-C2 is a selective regulator of SMN2 gene splicing, a risdiplam analogue, a selective RNA-binding ligand that regulates pre-mRNA splicing and acts by binding to SMN2 pre-mRNA.SMN-C2 has the potential to be used in the... | |||
T12935 | SMN-C3 | MV8T2MCK57 | DNA/RNA Synthesis |
SMN-C3 (MV8T2MCK57) is an orally active modulator of SMN2 splicing, and has the potential to treat spinal muscular atrophy (SMA). | |||
T12718L | RG7800 | RO6885247 | Others , DNA/RNA Synthesis |
RG7800 (RO6885247) has the potential for spinal muscular atrophy treatment. RG7800 is an SMN2 splicing modifier. | |||
T9005 | VPC-80051 racemate | Others | |
VPC-80051 is the first small molecule inhibitor of hnRNP A1 splicing activity by using a computer-aided drug discovery approach. | |||
T16757 | Risdiplam | RO7034067,RG7916 | DNA/RNA Synthesis |
Risdiplam (RO7034067) (RG7916) is orally administered. Risdiplam is a centrally and peripherally distributed SMN2 pre-mRNA splicing modifier which increases survival motor neuron (SMN) protein levels[1]. | |||
T14847 | B I09 | Others , IRE1 | |
B I09, an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells. B I09 can be used to simulate the defects of XBP-1 in CLL cel... | |||
T4S21320 | ISOGINKGETIN | 4',4'''-Dimethylamentoflavone | MMP , Others |
1. ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion with potency comparable to that of rosiglitazone, a known modulator of adiponecti... | |||
T3628 | Madrasin | DDD00107587 | DNA/RNA Synthesis |
Madrasin (DDD00107587) is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. | |||
T74186 | PROTAC-O4I2 | Apoptosis , PROTACs | |
PROTAC-O4I2, a PROTAC ligand targeting splicing factor 3B1 (SF3B1), induced FLAG-SF3B1 degradation in K562 cells with an IC50 value of 0.244 μM. PROTAC-O4I2 induced apoptosis in K562 WT cells. | |||
T16551 | Pladienolide B | Apoptosis | |
Pladienolide B is a potent spliceosome inhibitor, a macrolide isolated from Streptomyces obtusususus Mer-12, which targets the SF3B1 subunit of the spliceosome.Pladienolide B exerts its antitumor effects by inhibiting pr... | |||
T23897 | CLK1/2-IN-3 | CLK1/2 inhibitor 3,CLK1/2-inhibitor-3,CLK1/2 IN 3,CLK1/2IN3 | CDK |
CLK1/2-IN-3 (Cpd-3) is a potent and selective CLK1 and CLK2 inhibitor with antiproliferative activity and inhibits the activities of CLK1, CLK2, SRPK1, SRPK2, and SRPK3.CLK1/2-IN-3 induces nuclear speckle enlargement, wh... | |||
T4S0181 | Hinokiflavone | MMP , BCL , E1/E2/E3 Enzyme | |
Hinokiflavone, a novel modulator of pre-mRNA splicing activity both in vitro and in cellulo, inhibits the assembly of the spliceosome, particularly blocking the formation of the B complex. Additionally, it acts as a SUMO... | |||
T38889 | Thailanstatin A | ||
Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50 =650 nM). Thailanstatin A inhibits multiple cancer cell lines via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the s... |