smad3

Expression system: Baculovirus Insect Cells
Length: 1-425, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 2-425, Full Length of Mature Protein
Activity: Not Tested

Expression system: Baculovirus Insect Cells
Length: 1-425, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-748, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 299-407, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 1-196, Full Length
Activity: Not Tested

Expression system: P. pastoris (Yeast)
Length: 1-186, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-289, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-552, Full Length
Activity: Not Tested

Expression system: HEK293 Cells
Length: 30-125, Partial
Activity: Not Tested

Expression system: Baculovirus Insect Cells
Length: 1-505, Full Length
Activity: Not Tested

Amelotin (AMTN) is a tooth enamel protein which is expressed in maturation-stage ameloblasts and also in the internal basal lamina of junctional epithelium, a unique epithelial structure attached to the tooth surface which protects against the constant microbiological challenge to the periodontium. TNF-α stimulates AMTN gene transcription in human gingival epithelial cells via C EBP1, C EBP2, and YY1 elements in the human AMTN gene promoter.AMTN mRNA levels increased at 6 h and reached maximum at 24 h in GE1 cells. Luciferase activities of the mouse AMTN gene promoter constructs were induced by TGFβ1. AMTN mRNA levels were induced at the initiation of apoptosis by TGFβ1, which mediated through the Smad3 bindings to SBEs in the mouse AMTN gene promoter. Amelotin (Amtn) is a recently identified enamel protein secreted by ameloblasts at late stage of enamel development. Runt‑related transcription factor 2 (Runx2) in combination with the coactivator core‑binding factor β (Cbfβ) regulates the early stages of tooth development.

Expression system: HEK293 Cells
Length: 1-199, Full Length of Mature Protein
Activity: Not Tested

Expression system: Baculovirus Insect Cells
Length: 18-415, Partial
Activity: Enzyme Activity

Serine threonine-protein kinase 16, also known as myristoylated and palmitoylated serine threonine-protein kinase, Protein kinase PKL12, TGF-beta-stimulated factor 1, TSF-1, MPSK1 and STK16, is a membrane protein that is ubiquitously expressed at very low levels. STK16 MPSK1 belongs to the protein kinase superfamily and Ser Thr protein kinase family. It contains one protein kinase domain. Transforming growth factor-beta (TGF-beta) shows a variety of biological activities in various organs or cells. Some factors such as Smads (Sma and Mad proteins) and TGF-beta activating kinase 1 have been characterized as signalling molecules downstream of TGF-beta. Several TGF-beta response elements have been identified such as cAMP response element, Smad binding element, and recognition sites for activating protein-1 and stimulating protein-1 in various gene promoters. STK16 MPSK1 is a unique factor with two biological functions, transcriptional regulation and protein phosphorylation, that may be involved in TGF-beta signals. STK16 MPSK1 is a protein kinase that acts on both serine and threonine residues. STK16 MPSK1 possessed DNA-binding ability and activated the TGF-beta responsive CNP promoter or vascular endothelial growth factor gene promoter which possesses a sequence element analogous to the TGF-beta responsive GC-rich element of the CNP promoter. STK16 MPSK1 did not directly activate a Smads-dependent promoter from plasminogen activator inhibitor 1 gene, but it showed enhancement in co-operation with Smad3 and Smad4. STK16 MPSK1 mRNA as well as its protein level were stimulated by TGF-beta treatment.