pterin

Pterin is a pteridine with antibacterial properties, identified in C. croceus. It inhibits the proliferation and biofilm formation of E. coli, P. aeruginosa, and S. mutans. Pterin holds potential for research in cancer and infections.

6-(L-1,2,3-Trihydroxybutyl)-pterin is a derivative of L-biopterin and represents an oxidized form of tetrahydro-L-biopterin (BH4) as well as D-biopterin. Concurrent administration of 6-(L-1,2,3-Trihydroxybutyl)-pterin (0.5%) with the carcinogen 4-dimethylaminoazobenzene can reduce the incidence of liver tumors in rats induced by 4-dimethylaminoazobenzene. Furthermore, 6-(L-1,2,3-Trihydroxybutyl)-pterin has been utilized as an internal standard for quantifying biopterin and neopterin in rat plasma using LC-MS.

Xanthopterin Hydrate is isolated from butterfly wings and could replace folic acid in the nutrition of many animal species.

Tripterin (Celastrol) is a natural product, a proteasome inhibitor that inhibits the pancreatic rennet-like activity of the 20S proteasome (IC50=2.5 μM). Tripterin has anti-inflammatory, anti-infectious, and immunomodulatory properties.

Fosdenopterin is a molybdenum cofactor deficiency.

Erythropterin, a Pterin derivative, is a heterocyclic compound commonly found in biological systems.

Leucopterin is a biologically active pterin-like compound. It is the white pigment found in the wings of the brassica butterfly and other butterflies, and can also be found in wasps and other insects.

6-Formylpterin (Pterin-6-aldehyde) is an inhibitor of Xanthine Oxidase (Ki ~0.6 nM) with potent neuroprotective effects against transient IRI in gerbils.6-Formylpterin induces intracellular ROS generation in HL-60 cells as well as apoptosis ( 6-Formylpterin inhibits the expression of iNOS, produces hydrogen peroxide intracellularly and restores the impaired bactericidal activity of human neutrophils.

7-Biopterin is a 7-substituted pterin.1It is formed by non-enzymatic rearrangement of 4a-hydroxy-tetrahydropterin in the absence of pterin-4a-carbinolamine dehydratase (PCD)in vitroand levels are elevated in the urine of hyperphenylalaninemia patients carrying heterozygous mutations in the PCBD gene encoding PCD.1,2

D-threo-Biopterin is a pterin compound identified in D. discoideum. At a concentration of 100 μM, D-threo-Biopterin enhances luminol chemiluminescence induced by the oxidizing agent chloramine-T.

Calycopterin is a natural product that can be used as a reference standard.

Xanthopterin could inhibit the growth of lymphocytes produced by concanavalin.

Tetrahydrobiopterin (BH4) is a cofactor for aromatic amino acid hydroxylases and an essential cofactor for nitric oxide synthase (NOS), which is used in the study of endothelial dysfunction such as hypertension, hypercholesterolemia, and diabetes.

7,8-Dihydro-L-biopterin is an oxidation product of tetrahydrobiopterin.

Methopterin shows the activation and bone resorption function of murine osteoclasts.

Sapropterin is a naturally occurring essential cofactor of the three aromatic amino acid hydroxylase enzymes, used in the degradation of amino acid phenylalanine and in the biosynthesis of dopamine, epinephrine, melatonin, norepinephrine, neurotransmitter

Ninopterin is an experimental antineoplastic and folic acid analog.

Thermopterin is isolated from Methanoculleus thermophilic.

10-Deazaaminopterin is a poly-gamma-glutamyl metabolite of the experimental anticancer drug, a folic acid antagonist, antineoplastic agent enzyme inhibitor.

10-Methyl-10-deazaaminopterin, a folate analog, exhibits antitumor activity.

11-Oxahomoaminopterin exhibits antifolate activity against two folate-requiring microorganisms and inhibited Lactobacillus casei DHFR.

2'-Fluoroaminopterin is a folic acid antagonist agent.

3'-Fluoroaminopterin is a folic acid antagonist agent.

5,10-Dideazaaminopterin is an antileukemic drug.