polyamine

ATP-polyamine-biotin is a cell-permeable, efficient kinase cosubstrate with conversions and kinetics similar to those of other known ATP analogues. APB shows a cytotoxicity EC50 value of 19 ± 1 mM. ATP-polyamine-biotin is shown to promote biotin labeling

γ-Aminobutyric acid (4-Aminobutyric acid) is the predominant inhibitory neurotransmitter in the central nervous system.

(Rac)-AMXT-1501 4HCl is a polyamine transport inhibitor that inhibits polyamine transport and acts synergistically with cisplatin in HNSCC. (Rac)-AMXT-1501 4HCl has potential antimicrobial activity and inhibits neuroblastoma cell proliferation and pneumococcal pod biosynthesis by targeting ornithine decarboxylase and polyamine transport.

MDL 72527 (N1,N4-Di(buta-2,3-dien-1-yl)butane-1,4-diamine dihydrochloride) is a polyamine oxidase (POA) inhibitor

N1-Acetylspermine trihydrochloride is a monoacetylated derivative of spermine which is an endogenous polyamine. N1-Acetylspermine trihydrochloride can be used in studies about the uptake of the anticancer polyamine analog bleomycin-A5 by the human carnitine transporter SLC22A16.

Delucemine Hydrochloride (Delucemine) is a polyamine NMDA receptor antagonist used in the study of neurological disorders such as depression and Alzheimer's disease.

α-(difluoromethyl)-DL-Arginine (RMI 71897) is an enzyma-activated, irreversible inhibitor of arginine decarboxylase for E. coli (Ki = 800 μM), Pseudomonas aeruginosa, and Klebsiella pneumoniae. At 0.01 mM, it has been shown to prevent osmotic stress-induced increases in arginine decarboxylase activity and putrescine synthesis in oat leaf cells. When combined with a variety of polyamine analogues, α-(difluoromethyl)-DL-Arginine inhibited the growth of Trypanosoma Crui in mammalian host cells at a minimum concentration of 10 mM and prevented the growth of Trypanosoma Crui in T-cell receptor alpha-deficient mouse models.

Isotretinoin (13-cis-Retinoic acid) binds to and activates nuclear retinoic acid receptors (RARs), which act as transcription factors that promote cell differentiation and apoptosis. This naturally occurring retinoic acid has potential antineoplastic activity, exhibits immunomodulatory and anti-inflammatory responses, and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization.

Arcaine sulfate is a NMDA antagonist.

Spermine (Neuridine) is a biogenic polyamine formed from spermidine. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria.

Spermine tetrahydrochloride (Musculamine tetrahydrochloride) is a polyamine involved in cellular metabolism found in all eukaryotic cells. It is a major natural intracellular compound capable of protecting DNA from free radical attack.

Spermidine (N-(3-Aminopropyl)-1,4-diaminobutane) inhibits NOS1 (nNOS). Spermidine binds and precipitates DNA and may be used for purification of DNA binding proteins. Spermidine activates PNK (polynucleotide kinase T4). Spermidine binds to and activates NMDA and has been shown to potentiate NMDA-induced currents in a concentration-dependent manner.

Spermidine trihydrochloride (4-Azaoctamethylenediamine trihydrochloride), a natural polyamine, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA).

N-(5-Aminopentyl)acetamide (N-Acetylcadaverine) is the acetylated form of the polyamine cadaverine. Cadaverine is produced by the breakdown of amino acids in living and dead organisms and is toxic in large doses. N-(5-Aminopentyl)acetamide is a promising biochemical marker for cancer and many other pathophysiological conditions.

Norspermine is a polyamine analogue ,used in the treatment of non-small cell lung carcinoma and breast cancer.

W 12 is a sulfonamide-containing naphthalene derivative that inhibits polyamine transporters (Ki = 5 μM).

BFCAs-1 is a polyamine polycarboxylic bifunctional chelating agent (BFCAs) with a broad range of applications in biology, chemistry, medicine and diagnostic imaging.

N1,N8-Diacetylspermidine hydrochloride is a polyamine found in human urine.

N1,N8-Diacetylspermidine is a polyamine found in human urine.N1,N8-Diacetylspermidine can be used as a marker for cancer and malignancy.

N8-Acetylspermidine dihydrochloride, a polyamine, can be produced in mammals through the acetylation of spermidine by spermidine/spermine N1-acetyltransferase (SSAT), followed by subsequent oxidation by [propylamine transferase].

OES2-0017 exhibits strong synergistic effects and growth inhibition in collaboration with polyamines within a low micromolar range. At low concentrations, OES2-0017 inhibits spermidine/spermine N1-acetyltransferase (SpeG) (IC50: 34.82 μM) and other polyamine detoxifying enzymes, while at higher concentrations, it disrupts bacterial membranes.

N12N is a polyamine inverse NMDA receptor agonist.

Pyrone-211 acts as a potent GPR84 agonist and an AKR1C3 inhibitor. It is involved in the extended polyamine pathway.

Claramine hydrochloride is a steroidal polyamine capable of crossing the blood-brain barrier. It modulates the properties of lipid membranes and safeguards cells against various biological toxins, including misfolded protein oligomers and bio-protein toxins.