nociception — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2024	A-803467	A 803467,A803467	Sodium Channel
	A-803467 is a selective NaV1.8 channel blocker.		Sodium Channel
T3S0870	Paederosidic acid methyl ester		ATPase , Potassium Channel , NO Synthase
	Paederosidic acid methyl ester has antinociception, is possibly related to the pathway of NO-cGMP-ATP sensitive K(+) channels.		ATPase , Potassium Channel , NO Synthase
T7775	A2764 dihydrochloride		Potassium Channel
	A2764 dihydrochloride is a highly selective inhibitor of TRESK.		Potassium Channel
T0692	Allopurinol	Zyloric,Zyloprim,Lopurin	ROS , Xanthine Oxidase
	Allopurinol (Zyloric) is a Xanthine Oxidase Inhibitor. The mechanism of action of allopurinol is as a Xanthine Oxidase Inhibitor.		ROS , Xanthine Oxidase
T6376	Allopurinol Sodium	Allopurinol sodium salt,Sodium allopurinol	ROS
	Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.		ROS
T1790	Fosaprepitant dimeglumine	L785298,MK-0517,Fosaprepitant dimeglumine salt	Neurokinin receptor
	Fosaprepitant dimeglumine (MK-0517) is the dimeglumine salt form of fosaprepitant, the water-soluble, N-phosphorylated prodrug of aprepitant, with antiemetic activity. Upon intravenous administration and rapid conversion...		Neurokinin receptor
T7173	[Leu5]-Enkephalin	Leucine enkephalin,Leucyl-enkephalin,Leu-enkephalin	Opioid Receptor , Endogenous Metabolite
	[Leu5]-Enkephalin (Leu-enkephalin) is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and μ-opioid receptors (Kis = 4.0 and 3.4 nM, respectively)		Opioid Receptor , Endogenous Metabolite
T15192	Eact		Chloride channel
	Eact is a selective and potent TMEM16A activator. It directly activates the TRPV1 channels in sensory nociceptors. Which also produces itch, acute nociception and thermal hypersensitivity.		Chloride channel
T3690	A-740003	A 740003	P2X Receptor
	A-740003 (A 740003) is an effective and specific P2X7 receptor antagonist (IC50: 18/40 nM, for rat/human). It can reduce nociception in animal models of persistent neuropathic and inflammatory pain, and also reduce neuro...		P2X Receptor
T7173L	[Leu5]-Enkephalin acetate(58822-25-6 free base)	Leucine enkephalin,Leu-enkephalin,Leucyl-enkephalin	Opioid Receptor , Endogenous Metabolite
	[Leu5]-Enkephalin acetate(58822-25-6 free base) is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and μ-opioid receptors (Kis = 4.0 and 3.4 nM, respectively)		Opioid Receptor , Endogenous Metabolite
T39529	AT-121 hydrochloride		Opioid Receptor
	AT-121 hydrochloride is a dual agonist of nociception and mu opioid receptor with Ki values of 3.67 and 16.49 nM, respectively.AT-121 hydrochloride is a safe, non-addictive, pain relieving compound with anti-injury and a...		Opioid Receptor
T9955	EX-A5758		NOS
	EX-A5758 is a novel putative small molecule nNOS-NOS1AP inhibitor, suppressing inflammatory nociception and chemotherapy-induced neuropathic pain and synergizes with paclitaxel to reduce tumor cell viability.		NOS
TP1083L	Neuromedin U (rat) acetate		Others
	Neuromedin U, rat acetate is a 23-amino acid brain-gut peptide. Neuromedin U (NMU), through its cognate receptor NMUR2 in the central nervous system, regulates several important physiological functions, including energy ...		Others
T68141	Seganserin		5-HT Receptor
	Seganserin, a non-selective 5-hydroxytryptamine 2-HT receptor antagonist, reversed the inhibitory effects of fluoxetine and quipazine on luteinizing hormone-induced hyperphagia, depression and nociception, and reversed t...		5-HT Receptor
TP2015L	HS 014 acetate(207678-81-7 free base)		Melanocortin Receptor
	HS 014 acetate is a potent and selective melanocortin MC4 receptor antagonist (Ki values are 3.16, 108, 54.4 and 694 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake in rats and no...		Melanocortin Receptor
T30239	Axomadol hydrochloride
	Axomadol hydrochloride has an effect on pupil diameter and nociception in healthy subjects.
T26475	A-286501
	A-286501 is an orally active adenosine kinase inhibitor (IC50=0.47 nM). A-286501 effectively attenuates nociception by a non-opioid, non-non-steroidal anti-inflammatory drug ADO, receptor mediated mechanism.
T39527	Se-DMC
	Se-DMC effectively reduces the inflammatory response, nociception, and neurobehavioral deficits induced by complete Freund's adjuvant (CFA) in mice.
T76484	[Tyr8,Nle11] Substance P
	[Tyr8,Nle11] Substance P, an analog of Substance P, is primarily a neuron-secreted peptide participating in diverse biological functions such as nociception and inflammation [1].
T37610	AT-121		Opioid Receptor
	AT-121 is a dual μ-opioid and neuropeptide receptor partial agonist (Kis 16.49 and 3.67 nM, respectively). It stimulates [35S]GTPγS binding to cell membranes expressing either μ-opioid receptors or neuropeptide receptors...		Opioid Receptor