nfat

NFAT inhibitor, Cell Permeable aceate is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. It can be used for the research of podocyte and diabetic nephropathy.

NFAT Inhibitor (VIVIT peptide) is a cell-permeable compound that selectively inhibits the calcineurin-mediated dephosphorylation of NFAT.

NFAT Inhibitor acetate (VIVIT peptide acetate) is a cell-permeable and selective NFAT peptide inhibitor of calmodulin phosphatase-mediated NFAT dephosphorylation.

Peptide P60 acts as a FOXP3 inhibitor. This compound can penetrate cells to hinder FOXP3's nuclear translocation and diminish its ability to suppress transcription factors NF-κB and NFAT. Peptide P60 also suppresses the immunosuppressive activity of regulatory T cells (Treg) derived from mice and humans, while enhancing effector T cell stimulation in vitro. Moreover, Peptide P60 can induce a lymphoproliferative autoimmune syndrome, displaying pathological characteristics similar to those observed in scurfy mice lacking functional Foxp3. Additionally, Peptide P60 has the potential to boost the immunogenicity of cancer and viral vaccines.

NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. Improves symptoms in a mouse

SOR-C13 is an inhibitor of transient receptor potential cation channel vanilloid family member 6 (TRPV6, CaT1 or CATL) with potential antineoplastic activity. TRPV6 calcium channel inhibitor SOR-C13 binds to TRPV6 and prevents the influx of calcium ions into TRPV6-expressing tumor cells. This inhibits the activation of nuclear factor of activated T-cell (NFAT) transcription complex which may result in an inhibition of calcium-dependent cancer cell proliferation and an induction of apoptosis in tumor cells overexpressing TRPV6.