neutrophil elastase (human)

NeutrophilElastase(NEG) serves as a biomaterial or organic compound applicable in life sciences research.

BAY-678 is a human neutrophil elastase (HNE; IC50: 20 nM) inhibitor with oral bioactivity, potency and selectivity.BAY-678 is a chemical probe recommended by the Structural Genomics Consortium (SGC).

ZD-0892 is a selective and potent inhibitor of neutrophil elastase, targeting human neutrophil elastase and porcine pancreatic elastase with Kis of 6.7 nM and 200 nM, respectively.

Lodelaben (Declaben, SC-39026) is a reversible, non-competitive inhibitor of human neutrophil elastase (HNE), characterized by specificity and potency (IC50=0.5 μM, Ki=1.5 μM).

GW-311616 hydrochloride is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).

SSR69071 is a potent, orally active, and selective inhibitor of neutrophil elastase, displaying higher affinity for human elastase (Ki = 0.0168 nM) compared to rat (Ki = 3 nM), mouse (Ki = 1.8 nM), and rabbit (Ki = 58 nM) elastases [2]. It reduces myocardial infarct size following ischemia-reperfusion injury [1] and has potential for treating chronic obstructive pulmonary diseases, asthma, emphysema, cystic fibrosis, and various inflammatory diseases.

2-CHLOROMETHYL-1,1-DIOXO-1,2-DIHYDRO-1LAMBDA*6*-BENZO[D]ISOTHIAZOL-3-ONE targets the Neutrophil elastase (human).

AE-3763 is a peptide-based inhibitor of human neutrophil elastase with an IC50 of 29 nM.

BAY-677, serving as an inactive control for BAY-678, is distinguished by BAY-678's capabilities as an orally bioavailable, selective, and cell-permeable inhibitor of human neutrophil elastase (HNE), showcasing a high potency with an IC50 of 20 nM[1]. Furthermore, BAY-678 has been publicly nominated as a chemical probe by the Structural Genomics Consortium (SGC)[2].

GW-311616 is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).

(R)-BAY-85-8501 is the less active enantiomer of BAY-85-8501, a selective and potent Human Neutrophil Elastase (HNE) inhibitor with an IC50 of 65 pM.

BAY-85-8501 is a selective, reversible, and potent inhibitor of Human Neutrophil Elastase (HNE) with an IC50 of 65 pM.

FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase (IC50s: 22 nM and 100 nM, respectively). FK706 has an anti-inflammatory ef

ZD8321 is an effective inhibitor of human Neutrophil elastase (Ki: 13±1.7 nM).

BAY-678 racemate is a racemate of BAY-678, an orally bioavailable, selective, and cell-permeable inhibitor of human neutrophil elastase (HNE; IC50: 20 nM).

CHF-6333 CATION is a compound that inhibits human neutrophil elastase.

CHF-6333 is an inhibitor targeting human neutrophil elastase.

Sivelestat sodium tetrahydrate (ONO5046 sodium tetrahydrate) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) sodium tetrahydrate has the potential for the study of acute lung injury acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.

Sivelestat sodium (EI 546 sodium) is a highly efficient inhibitor of human neutrophil elastase, improving sepsis-induced myocardial dysfunction by activating the PI3K AKT mTOR signaling pathway. It can be used in acute lung injury acute respiratory distress syndrome research.

Ici 186756 is a novel, effective, and selective inhibitor of human neutrophil elastase.

ICI 200355 is an inhibitor of human neutrophil elastase.

Ici 200880 is a human neutrophil elastase synthetic peptide inhibitor.

MDL 27324 is an inhibitor of human neutrophil elastase.

MDL-101146, (R)- is an effective orally active inhibitor of human neutrophil elastase.