n-acetyltransferase

MeAIB is an N-acetyltransferase inhibitor that inhibits SNAT2-related signaling pathways. MeAIB is a specific substrate for amino acid transport system a (ATA1). Amino acid transport system a (ATA1) regulates the uptake of short chain neutral amino acids by Na+ flow.

Remodelin hydrobromide (Remodelin HBR) is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.

N-Acetyl-5-hydroxytryptamine (O-Demethylmelatonin) , also known as Normelatonin, is the immediate precursor of melatonin. It is produced from serotonin by the enzyme aralkylamine N-acetyltransferase and is converted to melatonin by acetylserotonin O-methyltransferase. It can potently activate TrkB receptor.

N-Acetyl-L-phenylalanine (N-Ac-Phenylalanine) is an essential amino acid produced for medical, feed, and nutritional applications. It appears in large amount in urine of patients with phenylketonuria which is a human genetic disorder due to the lack of phenylalanine hydroxylase, the enzyme necessary to metabolize phenylalanine to tyrosine. Acetylphenylalanine is a product of enzyme phenylalanine N-acetyltransferase in the pathway phenylalanine metabolism.

4-Acetamidophenyl acetate, an impurity of Acetaminophen, which is a selective COX-2 inhibitor (IC50: 25.8 μM) and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.

AK-968-11563024 is an inhibitor targeting marine V. vulnificus NAT [(VIBVN)NAT] with an IC50 value of 18.86 µM. In V. vulnificus, NAT (aromatic amine N-acetyltransferase) plays a role in drug metabolism, contributing to drug resistance. Thus, AK-968-11563024 can be used for research related to drug tolerance.

AANAT-IN-1 (compound 30) is an effective inhibitor of arylalkylamine N-acetyltransferase (AANAT) with an IC50 value of 10μM. AANAT plays a role in melatonin synthesis and is linked to disorders characterized by abnormally high melatonin levels, such as seasonal affective disorder (SAD).

N4-Acetylcytidine-13C5 is a 13C-labeled version of N4-acetylcytidine (T4456), an endogenous nucleoside metabolite produced from tRNA degradation. It is synthesized by enzymes such as N-acetyltransferase 10. N4-acetylcytidine may play a role in maintaining the activation of the NLRP3 inflammasome by inducing the expression and release of HMGB1. Additionally, it influences the stability and translation efficiency of mRNA, tRNA, and rRNA (e.g., enterovirus71RNA) through modification. This compound is utilized in studies related to cancer, neuroinflammatory diseases, viral infections, and obesity.

Monosodium N-acetylglutamate is the sodium salt of N-acetylglutamate, biosynthesized from glutamate and acetylornithine by ornithine acetyltransferase, and from glutamic acid and acetyl-CoA by the enzyme N-acetylglutamate synthase.

MeIQx (MeIQx) is a food-derived carcinogen that has been found in high temperature-cooked fish and meats.1It is activated by hydroxylation and subsequent O-acetylationviathe cytochrome P450 (CYP) isoform CYP1A2 and N-acetyltransferase 2, respectively, in UV5 cells expressing the human enzymes to a metabolite that reacts with DNA to form adducts.2MeIQx (200 and 400 ppm in the diet) induces tumor formation in rats.3

CAY10685 is a cell-permeable analog of the lysine acetyltransferase inhibitor CPTH2 that incorporates an alkyne functional group enabling click chemistry–based labeling strategies, and through inhibition of N-acetyltransferase 10 activity. CAY10685 has been extensively applied to modulate chromatin organization, facilitating detailed investigations into alterations of nuclear architecture associated with oncogenesis and specific laminopathies in advanced epigenetic and cell biology studies.

ANAT Inhibitor-1 serves as an inhibitor of human aspartate N-acetyltransferase (ANAT), targeting Canavan disease.

NSC 694621 is a PCAF and histone acetyltransferase (HAT) inhibitor that forms a covalent bond with Cys574, the active site of PCAF, thereby irreversibly inhibiting its acetyltransferase activity, and is able to inhibit the proliferation of SK-N-SH and HCT116 cells, which has anticancer potential.

NAT2-IN-1 (APA) is a selective inhibitor of the drug metabolism enzyme N-acetyltransferase 2 (NAT2), effectively targeting and eliminating cells with reduced NAT2 activity [1].

Diethylnorspermine, also known as DENSPM, BE-333, DE-333 and N(1),N(11)-Diethylnorspermine, is a highly potent known inducer of the polyamine catabolic enzyme, spermidine/spermine N1-acetyltransferase (SSAT). A designed polyamines (PAs) analog which induces cell cycle arrest, inhibits proliferation and induces apoptosis in melanoma, breast, prostate, lung and colon cancer cells..

GlmU-IN-5175178 is an inhibitor of the acetyltransferase activity of Escherichia coli N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU).

N-acetylglucosamine-1-P uridyltransferase (AGX1) (GlcNAc1pUT) is a bifunctional enzyme that catalyzes the synthesis of UDP-GlcNAc by coupling GlcNAc-1-P and UTP through an uridyltransfer reaction, exhibiting both acetyltransferase and uridyltransferase activities, and is exclusive to prokaryotes [1].

Naa50-IN-1 (Compound 4a) is a potent inhibitor of N-α-Acetyltransferase 50 (Naa50), demonstrating an IC50 of 7 mM, with potential applications in cancer research [1].

NAT1-IN-1 (compound 350) is a potent inhibitor targeting N-acetyltransferase 1 (NAT1), with an IC50 of 44 nM. It is applicable in the study of diseases characterized by metabolic hyperactivity, such as amyotrophic lateral sclerosis, cancer cachexia, and sepsis.

Acetaminophen-D7 is the deuterated form of Acetaminophen. Acetaminophen (T0065) (Paracetamol) acts as a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM. Additionally, it serves as an effective inhibitor of hepatic N-acetyltransferase 2 (NAT2). Acetaminophen (T0065) is widely utilized as an antipyretic and analgesic agent.

Acetaminophen-13C2,15N is an isotopically labeled version of Acetaminophen, incorporating both 13C and 15N atoms. Acetaminophen (T0065) (Paracetamol) serves as a selective inhibitor of cyclooxygenase-2 (COX-2) with an IC50 value of 25.8 μM. It is also a potent inhibitor of hepatic N-acetyltransferase 2 (NAT2). Acetaminophen (T0065) is widely utilized as an antipyretic and analgesic agent.

Acetaminophen-13C6 is a 13C-labeled form of Acetaminophen. It functions as a selective inhibitor of cyclooxygenase-2 (COX-2) with an IC50 value of 25.8 μM. Additionally, Acetaminophen (T0065) is an effective inhibitor of hepatic N-acetyltransferase 2 (NAT2) and is widely used as an antipyretic and analgesic agent.

N-Acetyl-5-hydroxytryptamine (Standard) is a reference standard for research and analysis in studies involving N-Acetyl-5-hydroxytryptamine. N-Acetyl-5-hydroxytryptamine (O-Demethylmelatonin) , also known as Normelatonin, is the immediate precursor of melatonin. It is produced from serotonin by the enzyme aralkylamine N-acetyltransferase and is converted to melatonin by acetylserotonin O-methyltransferase. It can potently activate TrkB receptor.

Acetylisoniazid (Standard) is a reference standard for research and analysis in studies involving Acetylisoniazid. Acetylisoniazid is a metabolite of Isoniazid, formed through the catalysis of N-acetyltransferase (NAT). Isoniazid exhibits bactericidal properties against rapidly dividing mycobacteria and possesses antitubercular activity.