mdk

iMDK quarterhydrate is a potent PI3K inhibitor that inhibits the growth factor MDK (also known as midkine or MK). iMDK quarterhydrate synergistically inhibits non-small cell lung cancer (NSCLC) with MEK inhibitors without harming normal cells and mice.

MDK-6983 (MDK-6983) is an inhibitor of autophagy and disrupts the dynamics of actin cytoskeleton in human melanoma cells.

MDK-4025 is an inhibitor of the high voltage-activated (HVA) Ca2+ current in pyramidal neurons.

MDK-4683, also known as CA IX/XII Inhibitor, is a hCA IX and hCA XII inhibitor.

MDK-4823, also known as LMPTP inhibitor1, is a potent low-molecular-weight tyrosine phosphatase (LMPTP) inhibitor. LMPTP is highly expressed in insulin-target tissues. LMPTP promotes diabetes and insulin resistance in obesity.

MDK-0738 is a potent and selective aldo-keto reductase 1C3 inhibitor.

MDK-0757 is a novel inhibitor of heat shock protein 90 (Hsp90).

MDK-2959 is a potent inhibitor of protein tyrosine phosphatase sigma (PTPsigma).

MDK-3046 is a YycG histidine kinase (HK) inhibitor with potent antibiofim activity against Staphylococcus epidermidis.

MDK-3298 is a reversible covalent inhibitor of Mcl-1, a target of protein-protein interaction (PPI).

MDK-3345 is a reversible covalent inhibitor for Mcl-1.

MDK-4204, an anticancer agent, shows significant anti-cancer activity with IC50 values of 8.8 µM and 9.5 µM in PC-3 and DU-145 cells, respectively.

MDK-4624 is a AMPKα1 activator. MDK-4624 inhibits Helicobacter pylori-induced oxidative stresses and gastric epithelial cell apoptosis. MDK-4624 attenuates dexamethasone-induced osteoblast cell death. MDK-4624 potently inhibits melanoma cell proliferation

MDK-5432, also known as AMPA stabilizer (R,R)-2a, is the most potent AMPA stabilizer.

MDK83190 (Apoptosis Activator 2) is a potent apoptosis activator, induceing caspase-3 activation, PARP cleavage, and DNA fragmentation .

MDK5466 is an Flt3 inhibitor that acts by preventing glutamate-induced cell death.

MDK6204 is a selective inhibitor of CLK1 and CLK2.

MDK0734 is a selective inhibitor of cathepsin B endopeptidase and exopeptidase activities.

MDK08445 is an important intermediate or precursor for the synthesis of Cefiderocol, a potent siderophore cephalosporin antibiotic.

MDK49781 is a useful chemical intermediate for drug synthesis.

MDK71803 is an important intermediate or precursor for the synthesis of Cefiderocol, a potent siderophore cephalosporin antibiotic with a catechol moiety on the 3-position side chain.

MDK7677 is a selective inhibitor of cathepsin B endopeptidase and exopeptidase activities.

MDK8228 is an inhibitor of CBP/p300 and BRD4 bromodomain. MDK8228 downregulates IL-6, IL-ß and IFN-ß in macrophages.

iMDK quarterhydrate, a potent PI3K inhibitor, is effective in inhibiting the growth factor MDK (also known as midkine or MK) while demonstrating suppression of non-small cell lung cancer (NSCLC). In combination with a MEK inhibitor, iMDK quarterhydrate demonstrates cooperative inhibition of NSCLC without causing harm to normal cells and mice [1].