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  • Indoleamine 2,3-Dioxygenase (IDO)
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Results for "

indoleamine2,3dioxygenase

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    31
    TargetMol | Inhibitors_Agonists
  • Natural Products
    7
    TargetMol | Natural_Products
Necrostatin-1
Necrostatin 1, Nec-1
T18474311-88-0
Necrostatin-1 (Nec-1) is a specific RIP1 inhibitor and necrotic apoptosis inhibitor, which inhibits TNF-α-induced necrotic apoptosis and also inhibits IDO.
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Palmatine chloride
T271810605-02-4
Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.
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TargetMol | Inhibitor Hot
epacadostat
INCB 024360, IDO Inhibitor 1
T35481204669-58-8
Epacadostat (INCB 024360) is an oral, potent and selective IDO1 inhibitor with IC50 value of 71.8 nM.
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TargetMol | Inhibitor Hot
Linrodostat
BMS-986205
T45321923833-60-6
Linrodostat (BMS-986205) is a selective inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1).
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TargetMol | Inhibitor Hot
Palmatine
Burasaine, Berbericinine
T5S08023486-67-7
1. Palmatine (Burasaine) is an inhibitor of dopamine generation. 2. Palmatine could potentially be developed for the treatment of flavivirus infections. 3. Palmatine has been used in the treatment of jaundice, dysentery, hypertension, inflammation, and liver-related diseases.
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Indoximod
NLG-8189, Indoximod (NLG-8189), 1-Methyl-D-tryptophan
T6543110117-83-4
Indoximod (NLG-8189) is a methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2, 3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function. Tryptophan depletion is associated with immunosuppression involving T cell arrest and anergy.
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4-Phenyl-1H-1,2,3-triazole
T782351680-44-0
4-Phenyl-1H-1,2,3-triazole, an inhibitor of the enzyme IDO1 (IC50: 60 µM), is utilized in cancer research [1].
    8-10 weeks
    Inquiry
    IDO1-IN-21
    T786872892432-98-1
    IDO1-IN-21 (compound 10m), with an IC50 of 0.64 μM, acts as an IDO1 inhibitor and has demonstrated efficacy in suppressing tumor growth in murine models [1].
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    6-8 weeks
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    IDO1/TDO-IN-6
    T787952948772-71-0
    IDO1 TDO-IN-6 (compound 11) is a dual inhibitor targeting IDO1 and TDO, exhibiting IC50 values of 2.25 μM for IDO1 and 2.89 μM for TDO, with Ki values of 1.9 μM for IDO1 and 3.1 μM for TDO, indicating its potential utility in cancer and immunology research [1].
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    8-10 weeks
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    IDO1-IN-22
    T789752126853-16-3
    IDO1-IN-22 (Compound 3) is an inhibitor of IDO1 with potent activity, showing a biochemical hIDO1 IC50 of 67.4 nM and HeLa hIDO1 IC50 of 17.6 nM. It demonstrates excellent antitumor efficacy in an LLC xenograft model and has a desirable pharmacokinetic (PK) profile [1].
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    8-10 weeks
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    1-Isopropyltryptophan
    1-IsoPT
    T791891219485-46-7
    1-Isopropyltryptophan (1-IsoPT), an IDO1 inhibitor, suppresses the expression of IDO-1 and IDO-2 mRNA induced by IFN-γ stimulation [1].
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    8-10 weeks
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    IDO1-IN-23
    T82082
    IDO1-IN-23 (compound 41) is a potent inhibitor of human indoleamine 2,3-dioxygenase 1 (IDO1), with an IC50 of 13 μM [1].
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    IDO-IN-12
    T116151888341-29-4In house
    IDO-IN-12 is an inhibitor of indoleamine 2,3-dioxygenase (IDO).
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    6-8 weeks
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    IDO-IN-7
    GDC-0919, NLG919, Navoximod, NLG-919 analogue
    T18061402836-58-1
    IDO-IN-7 (NLG-919 analogue) is a potent inhibitor of the IDO (indoleamine-(2, 3)-dioxygenase) pathway.
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    PF-06840003
    EOS200271, PF 06840003
    T4307198474-05-4
    PF-06840003 (EOS200271) is a specific and orally active IDO-1 inhibitor.
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    TargetMol | Inhibitor Sale
    IDO-IN-13
    GS-4361
    T116162291164-02-6
    IDO-IN-13 (GS-4361) is a potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor (EC50: 17 nM).
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    BMS-986242
    BMS986242
    T91641923844-48-7
    BMS-986242 is an orally active, potent, and selective indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor, suitable for cancer research.
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    TargetMol | Inhibitor Sale
    GNF-PF-3777
    8-Nitrotryptanthrin
    T1019977603-42-0
    GNF-PF-3777 (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2) with a Ki of 0.97 μM.
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    LY3381916
    IDO1-IN-5
    T119012166616-75-5
    LY3381916 is a selective, potent and brain penetrated inhibitor of IDO1 activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.
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    IDO1-IN-25
    T2000552841467-86-3
    IDO1-IN-25, a dual inhibitor of IDO1 TDO2, showcases IC50 values of 0.17 μM for IDO1 and 3.2 μM for TDO2. It effectively suppresses NO production in RAW264.7 cells following stimulation with lipopolysaccharide (LPS). Additionally, IDO1-IN-25 demonstrates anti-inflammatory properties in a mouse ear edema model of acute inflammation induced by croton oil.
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    4-6 weeks
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    IDO5L
    INCB024360 analogue, INCB14943
    T2647914471-09-3
    IDO5L (INCB024360 analogue) is an effective IDO1 inhibitor(IC50=10 nM).
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    NLG802
    T394762071683-99-1
    NLG802 is a prodrug of indoximod, serving as an orally active inhibitor of indoleamine 2,3-dioxygenase (IDO).
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    (S)-Indoximod
    L-Abrine, 1-Methyl-L-tryptophan, N-ME-Tryptophan
    T3S196721339-55-9
    (S)-Indoximod (L-Abrine) exhibits inhibition of rabbit small intestine indoleamine 2, 3-dioxygenase, competitive inhibition of IDO, reduction of Foxp3 protein expression in tumor of C57BL 6 mouse allografted with mouse LLC cells at 200 mg kg, induction of IDO1 protein expression in tumor of C57BL 6 mouse allografted with mouse LLC cells at 200 mg kg, antitumor activity against mouse LLC cells allografted in C57BL 6 mouse, antiproliferative activity against mouse LLC cells at 50 uM.
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    PCC0208009
    IDO-IN-2, DO-IN-2, IDO inhibitor 1
    T41421668565-74-9
    PCC0208009 (IDO-IN-2) is an IDO inhibitor.
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