hm1

DREADD agonist 21 is a potent agonist of human muscarinic acetylcholine M3 receptors (EC50=1.7 nM).

HM12 is a covalent inhibitor of L-/T-type calcium channels. This compound effectively suppresses Cav1.2 (L-type) and Cav3.2 (T-type) calcium channels, while showing selectivity for N-type channels. The inhibitory effect produced by HM12 is irreversible and persists even after elution. HM12 is applicable in research related to hypertension, pain, epilepsy, and other conditions.

PHM16 is an ATP competitive FAK and FGFR2 inhibitor.

OHM1, an analog of HIF1α CTAD, effectively inhibits the interaction between HIF1α CTAD and p300/CBP by targeting the CH1 domain with a binding affinity of 0.53 μM.

SAHM1 TFA is a chemical compound that acts as a Notch pathway inhibitor by stabilizing a hydrocarbon-stapled alpha helical peptide. It specifically targets the protein-protein interface, effectively preventing the assembly of the Notch complex.

Hm1a, a disulfide-rich spider-venom peptide and NaV1.1 activator, reestablishes the function of inhibitory interneurons in a Dravet syndrome (DS) mouse model [1].

δ-Theraphotoxin-Hm1b, a 42-amino acid peptide derived from the Togo starburst tarantula (Heteroscodra maculata) venom, selectively inhibits the inactivation of NaV1.1 channels without affecting NaV1.7 channels [1].

δ-Theraphotoxin-Hm1a is a selective NaV1.1 activator that induces pain and touch sensitivity, with potential applications in irritable bowel syndrome research [1].

Notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.

CWHM-1552 is an effective Plasmodium falciparum inhibitor. For the 3D7 and Dd2 strains, the IC50s are 51 nM and 53 nM.

Fispemifene (HM-101) is an estrogen receptor modulator (SERM) used to treat genitourinary syndromes and vaginal atrophy.

CWHM-1008 is an effective oral antimalarial drug. The EC50 values of the drug-sensitive Plasmodium falciparum 3D7 and drug-resistant Dd2 strains are 46 and 21 nM, respectively.

CHM-1 is an inducer of apoptosis, and displays potent antitumor ability in human hepatocellular carcinoma by activation of Cdc2 kinase activity. CHM-1 inhibits tubulin polymerization in vitro and in vivo.

CHM-1-P-Na is used as a hydrophilic prodrug of CHM-1.

XmAb 5592 is a Fc-engineered and humanized anti-HM1.24 antibody with anti-tumor activity, used in the study of multiple myeloma.

CWHM-12 is a potent inhibitor of αV integrins, with IC50 values of 0.2, 0.8, 1.5, and 1.8 nM for αvβ8, αvβ3, αvβ6, and αvβ1, respectively.

HM-1228 is an inhibitor specifically designed to protect carbon steel from corrosion in produced water systems in oil fields.

AP21998 is a selective ligand for the Fm (mutant FKBP) domain that binds to a single FKBPv. It disrupts FKBP-mediated oligomerization, inhibits the proliferation of transformed myeloid progenitors, and promotes their terminal myeloid differentiation. AP21998 destabilizes aggregates of CAD-hM1 receptor fusion proteins, allowing receptors to exit the endoplasmic reticulum and reach the plasma membrane. AP21998 is applicable in cancer research.

VU0456940 is a potent M1 PAM with excellent selectivity (hM1 EC50 = 340 nM, 14-fold leftward shift of the ACh CRC; hM2–hM5 inactive). VU0456940 potentiated the excitation of a subthreshold concentration of CCh in MSNs. VU0456940 shifted APP processing and