glycolytic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9352	Hydrocotarnine		Others
	hydrocotarnine is an inhibitor of Cbl.		Others
T3713	BAY-876		transporter
	BAY-876 is an orally active and selective inhibitor of glucose transporter 1 (GLUT1, IC50= 2 nM). BAY-876 exhibits >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4. BAY-876 also inhibits glycolytic metabol...		transporter
T8500	VLX600		OXPHOS , Mitochondrial Metabolism , Autophagy
	VLX600 is an iron-chelating oxidative phosphorylation (OXPHOS) inhibitor, is a cell-permeable anticancer agent. It acts by reducing mitochondrial oxidative phosphorylation in tumor cells.		OXPHOS , Mitochondrial Metabolism , Autophagy
T19344	Glycogen, Mussel	Glycogen	Endogenous Metabolite
	Glycogen, Mussel is a glycolytic intermediate and high-energy phosphate that ACTS as a form of energy storage for humans, animals, fungi and bacteria.		Endogenous Metabolite
T0239	Lonidamine	AF1890,DICA,Diclondazolic Acid	Apoptosis , Hexokinase , Mitochondrial Metabolism
	Lonidamine (Diclondazolic Acid) is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK).		Apoptosis , Hexokinase , Mitochondrial Metabolism
T37985	D-Fructose-6-phosphate (sodium salt hydrate)	D-Fructose-6-phosphate (sodium salt hydrate) (643-13-0 free base)
	D-Fructose-6-phosphate (sodium salt hydrate) is a sugar intermediate in the glycolytic pathway produced by the isomerization of glucose 6-phosphate by glucose phosphate isomerase, and is used in cancer research.
T4941	D-Fructose-6-phosphate disodium salt	D-FRUCTOSE 6-PHOSPHATE DISODIUM SALT	Others , Endogenous Metabolite
	D-Fructose-6-phosphate disodium salt (D-FRUCTOSE 6-PHOSPHATE DISODIUM SALT) is an important intermediate in the Carbohydrates pathway. The interconversion of glucose-6-phosphate and fructose-6-phosphate, the second step ...		Others , Endogenous Metabolite
T62758	PKM2 activator 2		PKM
	PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activator with an AC 50 value of 66 nM.PKM2 activator 2 has anti-tumor proliferative properties and attenuates the Warburg effect by normalizing cellular glycolytic metabol...		PKM
T36491	POMHEX		Glucokinase
	Pomhex, a cell-permeable potent enolase inhibitor with anticancer activity, is used in the study of cancer lethality.Pomhex, a racemic mixture, is a potent and selective ENO2 inhibitor.Pomhex is inhibitory to the glycoly...		Glucokinase
T40063	CBR-470-1		Nrf2
	CBR-470-1 is a potent inhibitor of glycolytic phosphoglycerate kinase 1 (PGK1) that activates NRF2 by increasing methylglyoxal levels. CBR-470-1 is a non-covalent Nrf2 activator with neuroprotective activity that protect...		Nrf2
T36953	Naphthofluorescein	Naphthafluorescein	HIF
	Naphthofluorescein （Naphthafluorescein） is a Mint3 inhibitor with potential antitumor and anti-inflammatory activities, inhibits the interaction between HIF-1 and Mint3, inhibits Mint3-dependent HIF-1 activity, and inhib...		HIF
T17224	VER-246608		Dehydrogenase , PDK
	VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively).VER-246608 disrupts Warburg metabolism an...		Dehydrogenase , PDK
T23953	Dactylarin	Altersolanol B
	Dactylarin is a cytotoxic antibiotic. Dactylarin isolated from Dactylaria lutea. Dactylarin interacts with thiols, which explains its inhibitory effect on the above glycolytic enzymes.
T76115	Pyruvate kinase
	Pyruvate kinase is a glycolytic enzyme that catalyzes the conversion of phosphoenolpyruvate and ADP to pyruvate and ATP [1] .
T76097	Aldolase
	Aldolase, a glycolytic enzyme and component of the VATPase complex, catalyzes the decomposition of fructose 1,6-diphosphate into dihydroxyacetone and glyceraldehyde 3-phosphate [1].
T70032	NCI-006
	NCI-006 is a potent new inhibitor of lactate dehydrogenase (LDH) that disrupts tumor growth in mice. LDH inhibition slows tumor growth but rapidly redirects pyruvate to support mitochondrial metabolism. Inhibiting both m...
T76111	Hexokinase (ScHEX1)
	Hexokinase (ScHEX1), a glycolytic enzyme, is inhibited by n-acetylglucosamine, which causes it to detach from the mitochondrial outer membrane. This detachment activates the NLRP3 inflammasome [1].
T76154	Triosephosphate isomerase
	Triosephosphate isomerase (TPI), a glycolytic enzyme, efficiently catalyzes the interconversion between dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The catalytic site of TPI is located at the dimer inter...
T83405	2,3-Diphosphoglyceric acid	2,3-DPG
	2,3-Diphosphoglyceric acid (2,3-DPG), an intermediate of the glycolytic pathway, allosterically binds to deoxygenated hemoglobin, stabilizing it and facilitating oxygen release at tissue sites. This binding decreases hem...
T60858	MOPIPP
	MOPIPP is a novel indolebased chalcone that can cross the blood-brain barrier. MOPIPP inhibits the tumor progression agaisnt glioblastoma cells. MOPIPP induces cellular vacuolization as well as increases autophagosomes n...