Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
Filter
Applied FilterClear all
TargetMol | Tags By Target
  • Transferase
    (13)
  • Apoptosis
    (2)
  • Autophagy
    (2)
  • Ras
    (2)
  • Telomerase
    (2)
  • Antifection
    (1)
  • Endogenous Metabolite
    (1)
  • NOD
    (1)
  • NOD-like Receptor (NLR)
    (1)
  • Others
    (15)
Filter
Search Result
Results for "

farnesyl transferase

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    31
    TargetMol | Inhibitors_Agonists
  • Natural Products
    5
    TargetMol | Natural_Products
BMS-214662
BMS214662
T10567195987-41-8In house
BMS-214662 is a selective farnesyl transferase inhibitor with antitumor activity, useful in studies of pancreatic, head and neck, and lung cancers.
  • $2,270
10-14 weeks
Size
QTY
Lonafarnib
Sch66336, Sarasar
T6302193275-84-2
Lonafarnib (Sch66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9 5.2 2.8 nM).
  • $41
In Stock
Size
QTY
TargetMol | Inhibitor Sale
FTI-277 hydrochloride
FTI 277 HCl
T2700180977-34-8
FTI-277 hydrochloride (FTI 277 HCl) is an effective and specific farnesyltransferase (FTase) inhibitor (IC50: 500 pM); this selectivity is about 100-fold than the closely related GGTase I.
  • $48
In Stock
Size
QTY
Tectol
TN651224449-39-6
Tectol has anti-plasmodial activity, it as a moderately active growth inhibitor with an IC50 3.44±0.20μM. It exhibited significant activity against human leukemia cell lines HL60 and CEM. Tectol may cause itchy dermatitis, the dermatitis appeared on the n
  • $109
In Stock
Size
QTY
TargetMol | Inhibitor Sale
ABT-100
T10223450839-40-4In house
ABT-100 is a potent, highly selective, and orally active inhibitor of farnesyl transferase [farnesyl-protein transferase] with broad-spectrum antitumor activity.
  • $977
3-6 months
Size
QTY
Prenyl-IN-1
T10512360561-53-1In house
Prenyl-IN-1 is a potent and selective prenylation inhibitor of geranylgeranyltransferase or farnesyltransferase.Prenyl-IN-1 shows anti-oxidative stress effects in a Parkinson's model. Prenyl-IN-1 showed anti-oxidative stress in a Parkinson's model.
  • $700
In Stock
Size
QTY
LB42708
T2678226929-39-1In house
LB42708 is an orally active farnesyltransferase (FTase) inhibitor (IC50: 0.8 1.2 2.0 nM toward H N K-ras).
  • $35
In Stock
Size
QTY
L-739750 2HCl
L-739750 2HCl(160141-08-2 Free base)
T27773L In house
L-739750 2HCl is a potent inhibitor of peptidomimetic farnesyltransferase, a novel pseudopeptide mimetic with potential anticancer activity.
  • $195
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Perillyl alcohol
Perilla alcohol, Isocarveol
T3314536-59-4
Perillyl Alcohol is a naturally occurring monoterpene related to limonene with antineoplastic activity. Perillyl alcohol (Isocarveol) inhibits farnesyl transferase and geranylgeranyl transferase, thereby preventing post-translational protein farnesylation and isoprenylation and activation of oncoproteins such as p21-ras, and arresting tumor cells in the G1 phase of the cell cycle.
  • $34
In Stock
Size
QTY
L-778123 hydrochloride
L 778123
T3182253863-00-2
The L-778123 hydrochloride is an inhibitor of FPTase (IC50: 2 nM) and GGPTase-I (IC50: 98 nM) in enzyme inhibition determination.
  • $38
In Stock
Size
QTY
TargetMol | Inhibitor Sale
FGTI-2734
T112821247018-19-4
FGTI-2734 is a dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor, exhibiting IC50 values of 250 nM and 520 nM for FT and GGT-1, respectively. It effectively prevents the membrane localization of KRAS, addressing the issue of KRAS resistance and inhibiting the growth of mutant KRAS patient-derived pancreatic tumors.
  • $47
In Stock
Size
QTY
FGTI-2734 mesylate (1247018-19-4 free base)
FGTI-2734 mesylate
T11282L2702297-24-1
FGTI-2734 mesylate, a RAS C-terminal mimetic compound with dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitory activities (IC50s of 250 nM and 520 nM for FT and GGT, respectively), mitigates KRAS resistance by preventing its membrane localization, effectively impeding mutant KRAS patient-derived pancreatic tumors.
  • $2,130
8-10 weeks
Size
QTY
FTI-2148 diTFA
T11330817586-01-9
FTI-2148 diTFA, a dual inhibitor targeting both farnesyl transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1), functions as a RAS C-terminal mimetic. It exhibits potent inhibitory capabilities with IC50 values of 1.4 nM for FT-1 and 1.7 μM for GGT-1, respectively.
  • $3,170
3-6 months
Size
QTY
FTI-2148
T11330L251577-09-0
FTI-2148 is an inhibitor of RAS C-terminal mimetic dual farnesyl transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1) (IC50s: 1.4 nM and 1.7 μM, respectively).
  • $3,170
3-6 months
Size
QTY
Tipifarnib (S enantiomer)
Tipifarnib S enantiomer, (S)-(-)-R-115777, (S)-Tipifarnib, IND-58359 S enantiomer
T17102192185-71-0
Tipifarnib S enantiomer ((S)-(-)-R-115777) is the S-enantiomer of Tipifarnib. Tipifarnib is a potent and specific farnesyltransferase inhibitor (IC50: 0.6 nM).
  • $47
In Stock
Size
QTY
BMS-214662 mesylate
T204276474010-58-7
BMS-214662 mesylate is a potent and selective farnesyl transferase inhibitor with an IC50 of 1.35 nM. It exhibits antitumor activity and is applicable in cancer research.
  • Inquiry Price
10-14 weeks
Size
QTY
L 739749
L-739749, L739749, L-739,749, L739,749, L 739,749
T24356156511-34-1
L 739749 is a CAAX peptidomimetic. It is also an inhibitor of farnesyl-protein transferase.
  • Inquiry Price
3-6 months
Size
QTY
R 115777
R-115777, R115777
T26012192185-68-5
R 115777 is an inhibitor of farnesyl transferase.
  • $1,520
Backorder
Size
QTY
Zaragozic acid D
T26347155179-14-9
Zaragozic acid D inhibits squalene synthase and ras farnesyl-protein transferase isolated from the keratinophilic fungus Amauroascus niger.
  • $1,520
Backorder
Size
QTY
Zaragozic acid D(2)
T26348155179-15-0
Zaragozic acid D(2) inhibits squalene synthase and ras farnesyl-protein transferase isolated from the keratinophilic fungus Amauroascus niger.
  • $1,520
Backorder
Size
QTY
α-hydroxy Farnesyl Phosphonic Acid
T35433148796-53-6
α-hydroxy Farnesyl phosphonic acid, a nonhydrolyzable analog of farnesyl pyrophosphate, acts as a competitive inhibitor of farnesyl transferase (FTase). At concentrations above 1 μM, it inhibits the processing of Ras in Ha-ras-transformed NIH3T3 cells.
  • TBD
35 days
Size
QTY
CP-609754
T380501190094-64-4
CP-609754 (LNK-754) is a potent and reversible farnesyltransferase inhibitor with potential anticancer activity. It inhibits farnesylation of recombinant human H-Ras (IC50=0.57 ng mL) and K-Ras (IC50=46 ng mL)[1]. In 3T3 H-ras (61L)-transfected cell lines, CP-609754 exhibits a slow on off rate, inhibiting mutant H-Ras farnesylation with an IC50 of 1.72 ng mL[1]. The compound is competitive for the prenyl acceptor (H-Ras protein) and noncompetitive for the prenyl donor farnesyl PPI, selectively inhibiting farnesylation of both H- and K-Ras proteins in 3T3 transfectants[1]. In vivo, CP-609754 shows antitumor activity against 3T3 H-ras (61L) tumors, with tumor regression achieved at 100 mg kg twice daily and an ED50 for tumor growth inhibition at 28 mg kg[1]. Continuous i.p. infusion of CP-609754 inhibits tumor growth by over 50% and reduces tumor farnesyltransferase activity by over 30% when plasma concentration is maintained above 118 ng mL[1]. [1]. Stacy L Moulder, et al. A phase I open label study of the farnesyltransferase inhibitor CP-609,754 in patients with advanced malignant tumors. Clin Cancer Res. 2004 Nov 1;10(21):7127-35.
  • $50
In Stock
Size
QTY
FTase-IN-1
T616822490538-41-3
FTase-IN-1 (compound 17a) is a highly effective farnesyl transferase (FTase) inhibitor with an IC50 value of 0.35 μM, demonstrating significant cytotoxicity and potent antitumor activity [1].
  • $1,520
6-8 weeks
Size
QTY
Tubulin polymerization-IN-25
T621352490538-46-8
Tubulin polymerization-IN-25 is a selective, dual tubulin polymerization (IC50: 1.11 μM) and farnesyl transferase (FTase) (IC50: 0.39 μM) inhibitor. polymerization-IN-25 exhibits cytotoxicity against cancer cells and blocks cell proliferation.
  • $1,520
6-8 weeks
Size
QTY