diterpene

PHYTOL (trans-Phytol) , a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects. It is a specific activator of PPARα.

20-DEOXYINGENOL is a natual product.

Epirosmanol is a diterpenoid containing a lactone moiety. Epirosmanol is a very weakly basic (essentially neutral) compound (based on its pKa).

Tanshinone IIA (Tanshinone B) is a diterpene quinone natural product that targets the protein kinase domain of VEGF/VEGFR2. Tanshinone IIA inhibits angiogenesis and exhibits anti-inflammatory, antioxidant, and therapeutic activities against coronary heart disease.

Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts growth inhibition and cytotoxic activity against a variety of human Y cell lines.

Abietic Acid (Sylvic acid) is a diterpene extracted from Pimenta racemosavar. grissea with antimicrobial, antiproliferative and anti-obesity activities. It inhibits lipoxygenase activity and may be studied in allergic diseases.

Isosteviol ((-)-Isosteviol), a common natural sweetener, belongs to tetracyclic diterpene glycosides. The pharmacology researches have suggested that stevioside and its hydrolysis products, steviol, isosteviol and steviolbioside, have many biological activities, such as reducing blood glucose, lowering blood pressure, anti-inflammation, anti-tumor, anti-diarrhea, antibacterium, immunoregulation, etc.

Leelamine hydrochloride, a tricyclic diterpene extracted from pine tree bark, inhibits the transcriptional activity of the androgen receptor, known to regulate fatty acid synthesis [2,3]. This compound acts as a cannabinoid receptor type 1 (CB1) agonist and suppresses SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells, irrespective of androgen receptor status.

Methyl carnosate is a diterpene compound with antioxidant and antimicrobial activity isolated from sage or rosemary.

Euphornin is a diterpene natural product isolated from Euphorbia dulcis that inhibits G protein-activated inwardly rectifying potassium channels GIRK1/4 (Kir3.1/3.4) with an IC50 of 2.63 µM, making it useful for studying atrial fibrillation.

Isotanshinone IIA, could non-competitively inhibit Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC50 0f 11.4 μM. is an abietane-type diterpene metabolite.

FLAVAMINE is a diterpene alkaloid.

Dihydrophytol is a saturated diterpene alcohol that functions as a key metabolic intermediate in the endogenous biosynthetic pathway leading to phytanic acid. Dihydrophytol is biochemically produced from the unsaturated alcohol phytol via a hydrogenation process that occurs primarily in the rumen of cattle through the metabolic activity of resident microorganisms.

Triptolide-D3 is the deuterated form of Triptolide (T2179). Triptolide is a diterpene triepoxide extracted from the roots of the Thunder God Vine and is known for its immunosuppressive, anti-inflammatory, antiproliferative, and antitumor properties. Triptolide acts as an inhibitor of NF-κB activation.

Cajucarinolide is a clerodane diterpene. It inhibits bee venom phospholipase A2 in vitro. Cajucarinolide possesses anti-inflammatory activity.

Linearol is a diterpene found in Sideritis L. spp. (Lamiaceae) with a broad range of demonstrated properties including antioxidant, anti-inflammatory, and anti-apoptotic activities.

Acanthoic acid is a pimaradiene diterpene isolated from Acanthopanax koreanum with anti-inflammatory activities. Acanthoic acid downregulates LPS-induced IL-1β, IL-6 and TNF-α production in BALF, attenuates lung histopathologic changes, and inhibits infla

Baccatin III (Baccatin Ⅲ) is a polycyclic diterpene which can be used for the semi-synthesis of paclitaxel and analogs. It has immunomodulatory and anticancer chemotherapeutic activities.

Ajugarin I is a clerodane diterpene, the major component of the shrub Ajuga remota.

Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud. Jolkinolide B induces apoptosis in cancer cells. Jolkinolide B can be used for studies on preventing and treating osteolysis.

Dactylomelol is a new type of diterpene from sea hare.

Isolinearol is a secodolastane diterpene.

Jatropholone A is a type of diterpene derivative of jarophone.

Kaurene is a tetracyclic diterpene.