chymotrypsin-like — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T17011	TCH-165		Proteasome
	TCH-165 is a small molecule modulator of proteasome assembly, resulting in an increase in 20S levels. The increase in the level of free 20S corresponds to enhanced proteolysis of IDPs.		Proteasome
T6027	Delanzomib	CEP-18770	Apoptosis , NF-κB , Proteasome
	Delanzomib (CEP-18770) is an orally active inhibitor of the chymotrypsin-like activity of proteasome (IC50: 3.8 nM). It only marginally inhibits the tryptic and peptidylglutamyl activities of the proteosome.		Apoptosis , NF-κB , Proteasome
T21854	Proteasome inhibitor IX	PS-IX,AM114	Proteasome
	Proteasome inhibitor IX (PS-IX) is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM). Proteasome inhibitor IX shows potent anticancer activity. Proteasome inhibitor IX exhibits HCT116 p53+/+ c...		Proteasome
T6941	PI-1840	PI 1840	PARP , Proteasome
	PI-1840（IC50 = 27 nM）is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and postglutamyl-peptide-hydrolysis-like (PGPH-L).		PARP , Proteasome
T7016	VR23		Apoptosis , Proteasome , Caspase
	VR23 is a potent proteasome inhibitor. Data shows IC50 =1 nM for trypsin-like proteasomes, IC50=50-100 nM for chymotrypsin-like proteasomes, and IC50=3 μM for caspase-like proteasomes.		Apoptosis , Proteasome , Caspase
T63321	20S Proteasome activator 1		Proteasome
	20S Proteasome activator 1 is a 20S proteasome activator with IC50 of 0.3 μM for trypsin-like sites, 0.7 μM for chymotrypsin-like sites and 1.8 μM for caspase sites. 20S Proteasome activator 1 prevents the accumulation o...		Proteasome
T8350	TPCK		Proteasome
	TPCK is an irreversible inhibitor of chymotrypsin-like proteases that affect cell proliferation, apoptosis, and tumorigenesis		Proteasome
T2016	MLN9708	Ixazomib Citrate	Proteasome
	MLN2238 suppresses the chymotrypsin-like proteolytic (β5) site of the 20S proteasome(Ki50=0.93 nM, IC50=3.4 nM/). The biologically active form of MLN9708 (Ixazomib Citrate) is MLN2238 in aqueous solutions or plasma.		Proteasome
T2122	Ixazomib	MLN2238	Proteasome , Caspase , Autophagy
	Ixazomib (MLN2238) , a second generation, boron-containing peptide proteasome inhibitor (PI), inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome (IC50/Ki: 3.4/0.93 nM, in cell-free assays), also i...		Proteasome , Caspase , Autophagy
T21617	MG-115	Z-LL-Nva-CHO	Proteasome
	MG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteas...		Proteasome
T36352	Suc-Leu-Tyr-AMC
	Suc-Leu-Tyr-AMC is a fluorescent substrate for calpain I and II and papain (another cysteine protease) that is used for measuring the chymotrypsin-like peptidase activity of the 20S proteasome (excitation max: 360 nm; em...
TN3228	7-Hydroxy-3-(4-hydroxybenzyl)chroman		Others
	7-Hydroxy-3-(4-hydroxybenzyl)chroman shows moderate inhibitory activity against a chymotrypsin-like activity of the proteasome.		Others
T26202	SP-Chymostatin B	alpha-Mapi
	SP-Chymostatin B is a potent inhibitor of many proteases, including chymotrypsin, papain, chymotrypsin-like serine proteinases, chymases, and lysosomal cysteine proteinases. It weakly inhibits human leucocyte elastase. I...
TP1308	Suc-Leu-Leu-Val-Tyr-AMC
	Suc-Leu-Leu-Val-Tyr-AMC is a fluorescent substrate for the 20S proteasome, other chymotrypsin-like proteases.
T37418	Z-LLL-AMC
	Z-LLL-AMC is a fluorogenic substrate for the chymotrypsin-like activity of the 26S proteasome or 20S proteolytic core. Chymotrypsin-like activity can be quantified by fluorescent detection of free AMC (also known as 7-am...
T80102	Z-Leu-Leu-Tyr-COCHO		Proteasome
	Z-Leu-Leu-Tyr-COCHO is a potent inhibitor of chymotrypsin-like activity, exhibiting a Ki value of 3.0 nM [1].		Proteasome
T10238	Aclacinomycin A hydrochloride	Aclarubicin hydrochloride	Proteasome
	Aclacinomycin A (Aclarubicin) hydrochloride is a fluorescent molecule and the first described non-peptidic inhibitor showing discrete specificity for the CTRL (chymotrypsin-like) activity of the 20S proteasome. Aclacinom...		Proteasome
T62080	GSK3494245
	GSK3494245 (DDD01305143) is a potent, selective, orally active inhibitor of chymotrypsin-like activity that binds to the proteasome of WTL.donovani at an IC50 of 0.16 μM, sandwiched between the β4 and β5 subunits. GSK349...
TN5655	Broussonin B
	Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin B can induce neurite outgrowth in PC-12 cells at concentration of 50 microg/ml, and show moderate inhibitory activities against a chymotrypsi...
T36338	AAF-CMK (trifluoroacetate salt)
	Tripeptidyl peptidase II (TPPII) is a serine peptidase of the subtilisin-type which removes tripeptides from the free NH2 terminus of oligopeptides. AAF-CMK is an irreversible inhibitor of TPPII commonly used at 10-100 μ...