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Results for "

ampk activator

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    65
    TargetMol | Inhibitors_Agonists
  • Natural Products
    7
    TargetMol | Natural_Products
AMPK activator
T22567849727-81-7
AMPK activator
  • Inquiry Price
6-8 weeks
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AMPK activator 4
T622382493239-46-4In house
AMPK activator 4 is a potent and selective AMPK activator that does not inhibit mitochondrial complex I. It selectively activates AMPK in muscle tissue, dose-dependently improves glucose tolerance in normal mice, significantly reduces fasting glucose levels, and improves insulin resistance in db db diabetic mice. [AMPK activator 4 has hypoglycemic effects.]
  • Inquiry Price
6-8 weeks
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QTY
AMPK activator 12
T78791431920-24-0In house
AMPK activator 12 is an AMPK activator and GDF15 inducer that elevates the expression level of GDF15 protein in human hepatocytes, which can be used for cancer research.
  • Inquiry Price
6-8weeks
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AMPK activator 1
T100691152423-98-7
AMPK activator 1 is an AMPK activator (compound No.1-75) with an EC50 of less than 0.1 μM.
  • Inquiry Price
6-8 weeks
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AMPK activator C2
Compound 2,Compound-2,C2
T237341428422-55-2
AMPK activator C2 is an AMPK allosteric activator.
    6-8 weeks
    Inquiry
    AMPK activator 2
    T606752410961-69-0
    AMPK activator 2 is a chloroformin derivative with potential anticancer activity, which can up-regulate AMPK signaling pathway and down-regulate mTOR 4EBP1 p70S6K, and inhibit proliferation and migration of human cancer cell lines (UMUC3, T24, A549).
    • Inquiry Price
    1-2 weeks
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    AMPK activator 2 hydrochloride( 2410961-69-0 Free base)
    AMPK activator 2 hydrochloride( 2410961-69-0 Free base)
    T60675L
    AMPK activator 2 hydrochloride is a fluoroguanidine-containing derivative that up-regulates the AMPK signaling pathway and down-regulates mTOR 4EBP1 p70S6K.AMPK activator 2 hydrochloride inhibits the proliferation and migration of human cancer cell lines (UMUC3, T24, A549).
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    AMPK activator 6
    T62052189299-03-4
    AMPK activator 6 (Compound GC) activates the AMPK pathway and reduces lipid content in HepG2 and 3T3-L1 cells. It significantly suppresses increases in total cholesterol (TC), low-density lipoprotein-C (LDL-C), triglyceride (TG), and other biochemical indices in blood serum, holding research value in non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome.
    • Inquiry Price
    6-8 weeks
    Size
    QTY
    AMPK activator 7
    T631171623138-03-3
    AMPK activator 7 (compound I-3-24) is an AMPK activator with an EC50 of 8.8 nM, useful in studies involving AMPK disorders such as type 2 diabetes, hyperglycaemia, metabolic syndrome, obesity, hypercholesterolaemia, and hypertension.
    • Inquiry Price
    8-10 weeks
    Size
    QTY
    ampk activator 8
    T631771852451-96-7
    AMPK activator 8 (Compound 2) is an AMP-activated protein kinase (AMPK) activator that acts on rAMPK α1β1γ1 (EC50: 11 nM), rAMPK α2β1γ1 (EC50: 27 nM), rAMPK α1β2γ1 (EC50: 4 nM), rAMPK α2β2 AMPK activator 8 can be used to study type 2 diabetes.
    • Inquiry Price
    6-8 weeks
    Size
    QTY
    AMPK Activator SC4
    T708621364692-88-5
    SC4 is a potent, direct AMPK activator. SC4 preferentially activates α2 complexes and stimulates skeletal muscle glucose uptake.
    • Inquiry Price
    10-14 weeks
    Size
    QTY
    ampk activator 9
    T726901858204-23-5
    AMPK Activator 9 (ZM-6), a potent activator of AMPK (α2β1γ1), demonstrates an EC50 of 1.1 µM, indicating its strong efficacy in activating AMPK. This compound holds promise for type 2 diabetes research, highlighting its potential application in understanding and possibly treating this condition.
    • Inquiry Price
    6-8 weeks
    Size
    QTY
    AMPK activator 11
    T792262948304-00-3
    AMPK Activator 11 is a nanomolar potent inhibitor of cell proliferation in various colorectal carcinomas (CRCs), acting through the selective activation of AMP-activated protein kinase (AMPK) and enhancement of oxidative phosphorylation (OXPHOS) (mitochondrial metabolism). This compound demonstrates particular efficacy in inhibiting RKO xenograft growth, rendering it useful for anti-tumor and metabolic disease research [1].
    • Inquiry Price
    6-8 weeks
    Size
    QTY
    AMPK activator 13
    T83127
    AMPK Activator 13 is a potent activator of the AMPK pathway, effectively inhibiting mitotic clonal expansion in 3T3-L1 cells and enhancing mitochondrial oxygen consumption rates. This compound is utilized in the study of obesity [1].
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    AMPK activator 14
    T856471356632-18-2
    AMPK activator 14 (compound 32), an orally active agent, effectively reduces fasted glucose and insulin levels in a db db mouse model of Type II diabetes [1].
    • Inquiry Price
    10-14 weeks
    Size
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    AMPK activator 15
    T201627
    AP39 Prodrug 1 (Compound M1) is a mitochondria-targeted H2S prodrug. In hepatocytes, it induces ROS-dependent mild mitochondrial uncoupling, activates mitochondria-associated AMPK, and inhibits Palmitic acid (PA)-induced lipid accumulation.
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    AMPK activator 16
    T2052022252336-04-0
    AMPK activator16 (compound 6) functions as an AMP-activated protein kinase (AMPK) inhibitor. It interacts effectively with crucial AMPK residues, significantly activating the enzyme. In N2a cells, AMPK activator16 enhances the expression of phosphorylated AMPK (p-AMPK) and its downstream signaling proteins, such as phosphorylated ACC (Acetyl-CoA Carboxylase) and phosphorylated raptor (p-raptor).
    • Inquiry Price
    10-14 weeks
    Size
    QTY
    AMPK-α1β1γ1 activator 1
    T831251943510-86-8
    AMPK-α1β1γ1 activator 1 (M1), an acyl glucuronide metabolite derived from an Indole-3-carboxylic Acid-based AMPK activator, selectively activates the β1 isoforms of human AMPK with an EC50 of 38.1 nM through direct binding to the human AMPK α1β1γ1 isoform; it is utilized in diabetic nephropathy research [1].
    • Inquiry Price
    8-10 weeks
    Size
    QTY
    MK8722
    T160991394371-71-1
    MK8722 is an effective and systemic activator of pan-AMPK.
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    TargetMol | Inhibitor Hot
    Metformin
    1,1-Dimethylbiguanide
    T8526657-24-9
    Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability. Metformin may improve glycemic control by increasing insulin sensitivity and decreasing intestinal glucose uptake, and is commonly used in type 2 diabetes research.
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    TargetMol | Inhibitor Hot
    Metformin hydrochloride
    Metformin HCl, 1,1-Dimethylbiguanide hydrochloride, 1, 1-Dimethylbiguanide hydrochloride
    T07401115-70-4
    Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride), a widely used anti-diabetic drug, exhibits potential anti-Y properties by inhibiting the proliferation of various Y cells, including colon and prostate.
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    AICAR
    NSC105823, AICAR (Acadesine), AICA Riboside, Acadesine
    T14772627-69-2
    AICAR (Acadesine) is an AMPK activator that causes ZMP accumulation, thereby mimicking the stimulatory effect of AMP on both AMPK and AMPKK. It is commonly used in research related to diabetes, cardiovascular diseases, and tumors.
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    Buformin hydrochloride
    NSC528218, NSC-528218, NSC 528218
    T200291190-53-0
    Buformin hydrochloride (NSC-528218) is a potent AMPK activator,an oral antidiabetic drug of the biguanide class. Buformin delays the absorption of glucose from the gastrointestinal tract increases insulin sensitivity and glucose uptake into cells and inhibits synthesis of glucose by the liver. Biguanides may antagonize the action of glucagon, thus reducing fasting glucose levels.
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    A-769662
    A 769662
    T2468844499-71-4
    A-769662 is an effective, reversible AMPK activator(EC50=0.8 μM).
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