14
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2348 | GSK2334470 | PDK | |
GSK2334470 is a novel PDK1 inhibitor (IC50: ~10 nM, in a cell-free assay), with no inhibitory at other close related AGC-kinases. | |||
T1837 | BX-912 | Apoptosis , VEGFR , PKA , Chk , CDK , PDK | |
BX-912 is a specific inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1, IC50: 12 nM). The selectivity of BX-912 is more 10 fold than C-Kit, EGFR, PKA, PKC etc. | |||
T1830 | BX795 | IκB/IKK , Chk , CDK , c-Kit , PDK , Autophagy | |
BX795 is an effective and selective PDK1 inhibitor (IC50: 6 nM), and its selectivity is 140- and 1600-fold for PDK1 over PKA and PKC in cell-free assays, respectively. Meanwhile, the selectivity for PDK1 is 100-fold than... | |||
T24677 | PS47 | PS 47,PS-47 | PDK |
PS-47(PS 47) is an inactive E-isomer of PS48. PS48 is an activator of PDK1. | |||
T12398 | MP7 | PDK1 inhibitor | PDK |
MP7 (PDK1 inhibitor) is a inhibitor of phosphoinositide-dependent kinase-1 (PDK1). | |||
T4046 | BX517 | PDK1 inhibitor 2,BX 517,BX-517 | Akt , PDK |
BX517 (PDK1 inhibitor 2) is a potent and selective inhibitor of PDK1. | |||
T16670 | PS210 | PDK | |
PS210 is a potent and selective activator of PDK1 (Kd: 3 μM), specifically targeting the PIF-binding pocket of PDK1, without acting against other protein kinases such as S6K, PKB/Akt, or GSK3. Its prodrug, PS423, serves ... | |||
T74830 | PDK-IN-1 | ||
PDK-IN-1 (compound 7o), a pyruvate dehydrogenase kinase (PDK) inhibitor, exhibits IC50 values of 0.03 and 0.1 μM against PDK1 and HSP90, respectively. This compound effectively targets the PDH/PDK axis, significantly red... | |||
T12412L | PDK4-IN-1 hydrochloride | Apoptosis , PDK | |
PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4)(IC50 value of 84 nM) | |||
T3895 | Polyphyllin I | Apoptosis , Akt , JNK , PDK , mTOR , Autophagy | |
Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D ha... | |||
T12412 | PDK4-IN-1 | Others | |
PDK4-IN-1 is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4)(IC50 value of 84 nM). | |||
T16450 | PDK1-IN-RS2 | PDK | |
PDK1-IN-RS2 inhibits the activation of the downstream kinases S6K1 by PDK1. PDK1-IN-RS2 is a mimic of the peptide docking motif (PIFtide) and is a substrate-selective PDK1 inhibitor (Kd: 9 μM). | |||
T17224 | VER-246608 | Dehydrogenase , PDK | |
VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively).VER-246608 disrupts Warburg metabolism an... | |||
T79723 | PDK-IN-2 | ||
PDK-IN-2 (Compound 1F), with an IC50 of 68 nM, is a potent PDK inhibitor that downregulates the expression of PDK1 and PDK4 in cells. It promotes mitochondrial bioenergetics, reduces glycolytic activity, and triggers apo... |