cyp3a — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T19792	1,3,7-Trimethyluric acid		Others
	1,3,7-Trimethyluric acid is a purine alkaloid that occurs as a minor metabolite of caffeine in humans. As an antioxidant, it has shown an ability to scavenge hydroxyl radicals as well as protective potential against lipi...		Others
T22437	Tazofelone	LY-213829	Others
	Tazofelone (LY-213829) is a NSAID used for the treatment of inflammatory bowel disease.		Others
T7788	2-Phenyl-2-(1-piperidinyl)propane		Others
	2-Phenyl-2-(1-piperidinyl)propane (PPP), an analog of phencyclidine		Others
T6246	Cobicistat	Tybost,GS-9350	P450 , HIV Protease
	Cobicistat (GS-9350) is a carbamate and thiazole derivative that functions as a CYTOCHROME P450 CYP3A INHIBITOR to enhance the concentration of ANTI-HIV AGENTS, with which it is used in combination, for the treatment of ...		P450 , HIV Protease
T77698	HCYP3A4 Fluorogenic substrate 1		Others
	hCYP3A4 Fluorogenic substrate 1 is a phthalimide derivative and shows low activity against COX.		Others
T64032	CYP3A4-IN-3
	CYP3A4-IN-3 is a specific, highly affinity cytochrome P450 3A4 (CYP3A4) (cytochrome P450 3A4 (CYP3A4)) inhibitor (IC50: 0.075 μM). CYP3A4-IN-3 is an analogue of ritonavir with a simpler structure and twice as much inhibi...
T63954	CYP3A4-IN-1
	CYP3A4-IN-1 is a potent inhibitor of cytochrome P450 3A4 (CYP3A4) (IC50: 0.085 μM).
T79343	HCYP3A4-IN-1
	hCYP3A4-IN-1 (compound C6) is a potent, orally active inhibitor of hCYP3A4, exhibiting IC50 values of 43.93 nM in human liver microsomes (HLMs) and 153.00 nM in the CHO-3A4 stably transfected cell line. It competitively ...
T64037	CYP3A4-IN-2
	CYP3A4-IN-2 is a specific inhibitor of cytochrome P450 3A4 (CYP3A4) (IC50: 0.055 μM). CYP3A4-IN-2 is a ritonavir analogue with a more hydrophobic R2 side group and stronger inhibition than ritonavir. CYP3A4-IN-2 is capab...
T2926	Schizandrin A		P450 , Virus Protease , Autophagy
	Schisandrin A, a primary active component extracted from the traditional Eastern medicine Schisandra chinensis, inhibits CYP3A activity, with an IC50 of 6.60 μM and a Ki of 5.83 μM.		P450 , Virus Protease , Autophagy
T13601	CDD3506	1-TRITYL-1H-IMIDAZOL-4-AMINE	P450
	CDD3506 (1-TRITYL-1H-IMIDAZOL-4-AMINE) increases high-density lipoprotein cholesterol by targeting hepatic CYP3A.		P450
T13600	CDD3505	4-nitro-1-trityl-1H-imidazole	P450
	CDD3505 (4-nitro-1-trityl-1H-imidazole) increases high-density lipoprotein cholesterol by targeting hepatic CYP3A.		P450
T21818	Pregnenolone Carbonitrile	Pregnenolone 16α-carbonitrile ,5-Pregnen-3β-ol-20-one-16α-carbonitrile	P450
	Pregnenolone Carbonitrile (5-Pregnen-3β-ol-20-one-16α-carbonitrile) is an activator of rodent-PXR and induces the expression of CYP3A.		P450
T22025	AG 045572		P450 , GNRH Receptor
	AG 045572 is a potent GnRH receptor antagonist that inhibits the GnRH receptor in humans and rats with Ki values of 6.0 nM and 3.8 nM, respectively.AG 045572 is metabolized by CYP3A and inhibits testosterone.		P450 , GNRH Receptor
T0120	Voriconazole	UK-109496	Antifection , Antifungal
	Voriconazole (UK-109496) is a triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 CYP3A.		Antifection , Antifungal
T21548	PF-4981517	CYP3cide	P450
	PF-4981517 (CYP3cide) is a efficient, specific and time-dependent inhibitor of cytochrome P4503A4 (CYP3A4). The IC 50 values for CYP3A activity are 0.03 μM,17 μM, and 71 μM for CYP3A4, CYP3A5, and CYP3A7, respectively. P...		P450
T6S0119	Dauricine		Apoptosis , Others , NF-κB
	1. Dauricine has pulmonary toxicity, can produce pulmonary injury in CD-1 mice by the metabolism of Dauricine mediated by CYP3A. 2. Dauricinec can pass the blood-brain barrier, and that P-glycoprotein has an important ro...		Apoptosis , Others , NF-κB
T8339	16α-Hydroxyprednisolone	16alpha-Hydroxyprednisolone	Others , Drug Metabolite
	16α-Hydroxyprednisolone is a stereoselective metabolite of the 22(R) epimer of the glucocorticoid budesonide		Others , Drug Metabolite
T6S1917	Schisandrol B	Gomisin A,TJN-101,Besigomsin,Gamma-Schisandrin,Schizandrol B,Wuweizi alcohol-B	P450 , Reactive Oxygen Species , Autophagy
	1. Schisandrol B (Besigomsin) may exert neuroprotective effects by attenuating the microglia-mediated neuroinflammatory response via inhibiting the TLR4-mediated NF-κB and MAPKs signaling pathways. 2. Schisandrol B has a...		P450 , Reactive Oxygen Species , Autophagy
T11002	Desethylamiodarone hydrochloride	N-desethylamiodarone hydrochloride,LB 33020 hydrochloride	Others
	Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is formed by the CYP3A isozyme. Amiodarone is an antiarrhythmic drug that inhibits ATP-sensitive potassium channels with an IC50 of 19.1 μM. It is the...		Others