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Natural Product Categories Natural Product Categories Magnoliales
Magnoliales is an order of early-diverging angiosperms that includes families such as Magnoliaceae, Annonaceae, and Myristicaceae, representing some of the most primitive flowering plant lineages. These plants are rich in structurally diverse secondary metabolites, including alkaloids, lignans, neolignans, and essential oils. In biomedical research, Magnoliales is highly significant due to its broad pharmacological activities, including neuroprotective, anti-inflammatory, antimicrobial, and anticancer effects. Magnolia-derived compounds, for instance, have been extensively studied for their anxiolytic and neuroactive properties. The evolutionary position of Magnoliales makes it a key group for understanding the early diversification of angiosperm chemistry and for identifying ancestral bioactive scaffolds relevant to modern drug discovery.
- (+)-MagnoflorineThalictrin, Magnoflorine, Escholine, EscholinT3S13192141-09-5(+)-Magnoflorine (Thalictrin) has sedative and anxiolytic effects, probably mediated by Magnoflorine through a GABAergic mechanism of action. Magnoflorine and Sinomenine have protective effects, are mediated by some mechanism other than prevention of micelle formation or protection of the erythrocyte membrane against osmotic imbalance.
- $33
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Cited - MicheliolideT568868370-47-8Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response.
- $39
SizeQTY - MyrislignanT4S1540171485-39-5Myrislignan has anti-inflammatory, and anti-cancer activities, it inhibited NF-κB signalling pathway activation, inhibited the proliferation of A549 cells in a dose- and time-dependent manner, it also significantly induced apoptosis and cell cycle arrest
- $39
SizeQTY - MagnololNSC 293099, 5,5'-Diallyl-2,2'-biphenyldiolT3000528-43-8Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation.
- $39
SizeQTY Cited - TetrahydromagnololTN226820601-85-8Tetrahydromagnolol can activate cannabinoid (CB) receptors.
- $33
SizeQTY - Sinapyl alcoholTN2440537-33-7Technical grade is a natural from Magnolia sieboldii
- $47
SizeQTY - MagnocurarineTN19026801-40-7Magnocurarine is a natural product from Magnolia officinalis.
- $251
SizeQTY - HonokiolNSC 293100T300135354-74-6Honokiol (NSC-293100) is the active principle of magnolia extract. It inhibits the activation of Akt and enhances the phosphorylation of ERK1/ERK2.
- $50
SizeQTY Cited - Epimagnolin ATN161041689-51-4Epimagnolin A is a lignan obtained from the flower buds of Magnolia fargesii, which is traditionally used in Asian medicine for treating headache and nasal congestion.
- $113
SizeQTY - DL-Syringaresinol(±)-SyringaresinolTN15941177-14-6DL-Syringaresinol ( (±)-Syringaresinol) is a lignan from ginseng berries with anti-inflammatory, antioxidant, analgesic and weak anti-mycobacterial activities.DL-Syringaresinol can delay oxidative stress-induced skin aging through autophagy, alleviate oxaliplatin-induced neuropathic pain and sepsis-induced cardiac dysfunction by inhibiting inflammatory responses. neuropathic pain and sepsis-induced cardiac dysfunction by inhibiting inflammatory responses.
- $196
SizeQTY - Magnoloside AMagloside ATN1906113557-95-2Magnoloside A (Magloside A) is a phenylethanol glycoside from M. obovata Thunb, a calmodulin phosphatase inhibitor.
- $84
SizeQTY - Myristic acidTetradecanoic acid, n-Tetradecanoic acid, CrodacidT3949544-63-8Myristic acid (Crodacid) , a 14 carbon saturated fatty acid, is a rare molecule in cells and is a substrate of some fatty acid desaturases. This compound has the ability to acylate proteins by covalently binding to the N-terminal glycine residues, in a process called N-terminal myristoylation. Myristoylation of substrate proteins by this fatty acid has the potential to activate and mediate many physiological pathways. Furthermore, saturated fatty acids have been reported to be essential for biological activities of lipopolysaccharides and have demonstrated the ability to induce expression of COX-2 and NFκB (nuclear factor κB) activation.
- $39
SizeQTY Cited - LiriodenineVLT045, SpermatheridineTN1875475-75-2Liriodenine is a natural alkaloid that induces apoptosis in various cancer cells by targeting caspase-3 and caspase-9, and exhibits antimicrobial, antifungal, antitumour, antiviral, and antiplatelet aggregation activities.
- $429
SizeQTY - 4-O-Methyl honokiol4-O-MethylhonokiolT1015368592-15-44-O-Methyl honokiol (4-O-Methylhonokiol) is a lignan-like compound obtained from Magnolia officinalis and Magnolia officinalis. It is a PPARγ agonist with antiangiogenic, anticancer, anti-inflammatory, and neuroprotective properties, and it can inhibit the activity of NF-κB, which can be used in cancer research.
- $52
SizeQTY - magnolin(+)-MagnolinT385731008-18-1Magnolin reduces the renal oxidative stress, suppresses caspase-3 activity, and increases Bcl-2 expression in vivo and in vitro. Magnolin has anti-inflammatory and antioxidative effects.
- $33
SizeQTY - KobusinTN183436150-23-9Kobusin, a bisepoxylignan compound isolated from Pnonobio biondii Pamp, demonstrates CFTR and CaCC chloride channel activation properties while exhibiting inhibitory effects on ANO1/CaCC channels.
- $84
SizeQTY - Fargesin(±)-FargesinT5S217831008-19-21. Fargesin ((+/-)-Fargesin) as a potential β1AR antagonist through cAMP/PKA pathway could protect against myocardial ischemia/reperfusion injury in rats. 2. Fargesin improves dyslipidemia and hyperglycemia by activating Akt and AMPK in WAT.
- $64
SizeQTY - MyristicinMyristicineT9113607-91-0Myristicin (Myristicine) is a natural product found in spices and umbelliferous plants. Myristicin has anti-cholinergic, Antibacterial, and hepatoprotective effects, it also has anti-inflammatory properties related with its inhibition of NO, cytokines,chemokines, and growth factors in dsRNA-stimulated macrophages via the calcium pathway. Myristicin can induce Apoptosis as characterised by alterations in the mitochondrial membrane potential, cytochrome c release, Caspase-3 activation, PARP-cleavage and DNA fragmentation.5-HT ReceptorAntibacterialAnti-infectionApoptosisBcl-2 FamilyCaspaseCytochromes P450EGFRERKGABA ReceptorIL ReceptorNO SynthasePARP
- $34
SizeQTY - DehydrodiisoeugenolT6S15432680-81-11. Dehydrodiisoeugenol has anti-inflammatory activity. (1). Dehydrodiisoeugenol inhibited the expression of the COX-2 in RAW264.7 murine macrophages stimulated with LPS. (2). Dehydrodiisoeugenol inhibited LPS-stimulated phosphorylation-dependent proteolys
- $30
SizeQTY - AtherosperminineTN34665531-98-6Atherosperminine shows cholinesterase inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Atherosperminine shows strong anti-plasmodial activity against Plasmodium falciparum, with the IC50 value of 5.80 uM, it also s
- $95
SizeQTY - (+)-Magnoflorine chlorideThalictrine chloride, Magnoflorine chloride, Escholine chloride, Corytuberine methochlorideT4S13216681-18-1(+)-Magnoflorine chloride (Escholine chloride) has anti-inflammatory activity, it can inhibit inflammations.
- $30
SizeQTY - (+)-Magnoflorine iodideThalictrine iodide, Magnoflorine iodide, Corytuberine MethiodideT3S13204277-43-4(+)-Magnoflorine iodide (Thalictrine iodide) has anti-inflammatory activity, it can inhibit inflammations.
- $30
SizeQTY - Licarin BLicarine B, (-)-Licarin BT4S154551020-87-21.(-)-Licarin B (Licarine B) has anti-mycobacterial activity.
- $33
SizeQTY - (Iso) (-)-Zuonin Arel-(8R,8'R)-dimethyl-(7S,7'R)-bis(3,4-mT3S1541178740-32-4Rel-(8R,8'R)-Dimethyl-(7S,7'R)-bis(3,4-methylenedioxyphenyl)tetrahydrofuran is a chemical component found in the fruit of nutmeg.
- $40
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