Hyperuricemia Modeling

Hyperuricemia is a condition characterized by elevated blood uric acid levels caused by abnormalities in purine metabolism. It may progress to gout and renal dysfunction. Common modeling methods include administration of xanthine oxidase inhibitors combined with high-purine diets, as well as injection of uric acid salts. These models are widely used to investigate the regulatory mechanisms of uric acid metabolism, expression of renal urate transporters, and the screening of anti-hyperuricemic drugs.