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Endocrinology and Metabolism Disease Modeling Endocrinology and Metabolism Disease ModelingHyperuricemia Modeling
Hyperuricemia is a condition characterized by elevated blood uric acid levels caused by abnormalities in purine metabolism. It may progress to gout and renal dysfunction. Common modeling methods include administration of xanthine oxidase inhibitors combined with high-purine diets, as well as injection of uric acid salts. These models are widely used to investigate the regulatory mechanisms of uric acid metabolism, expression of renal urate transporters, and the screening of anti-hyperuricemic drugs.
Inosine
T043758-63-9
Inosine (NSC-20262), an endogenous purine nucleoside produced by the catabolism of adenosine, is an agonist of adenosine receptors A1R and A2AR. Inosine has anti-inflammatory, immunomodulatory, antinociceptive and neuroprotective effects.
- $29
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Adenine
T006473-24-5
Adenine is a purine-derived nucleobase and one of the four bases of DNA. It is an important chemical component of both DNA and RNA, involved in cellular respiration, the formation of ATP and coenzymes NAD and FAD, as well as protein synthesis. Adenine is commonly used to induce chronic kidney injury models.
- $50
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Fructose
T29547660-25-5
Fructose is a simple ketose monosaccharide widely found in many plants and commonly combines with glucose to form the disaccharide sucrose. It can be used to induce hyperuricemia and diabetes models.
- $48
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DMBA
T3669657-97-6
DMBA (7,12-Dimethylbenz[a]anthracene) is a carcinogenic polycyclic aromatic hydrocarbon (PAH) that can be used to induce animal models of leukemia, liver cancer, breast cancer, skin cancer, and lung cancer. It is also capable of inducing programmed cell death (apoptosis) in A20.1 murine B-cell lymphoma.
- $30
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Ethambutol
T706274-55-5
Ethambutol is an oral anti-tuberculosis drug that inhibits arabinosyl transferase activity, thereby interfering with the synthesis of arabinogalactan and preventing cell wall formation to exert its antibacterial effect; it can also be used for animal models of hyperuricemia and optic neuropathy.
- $33
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Potassium oxonate
T59872207-75-2
Potassium oxonate is a uricase inhibitor that suppresses the phosphorylation of 5-FU to 5-fluorouridine-5'-monophosphate and is commonly used to establish hyperuricemia models.
- $44
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Ethambutol dihydrochloride
T08101070-11-7
Ethambutol dihydrochloride is an anti-mycobacterial compound that inhibits arabinosyl transferase activity to prevent cell wall formation and can be used to induce hyperuricemia models.
- $29
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Adenine hemisulfate
T6369321-30-2
Adenine hemisulfate is a purine-based nucleobase and an essential chemical component of DNA and RNA. It plays a key role in cellular respiration, the formation of ATP and coenzymes such as NAD and FAD, as well as in protein synthesis. It is commonly used to induce animal models of chronic liver and kidney injury and hyperuricemia.
- $48
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Adenine hydrochloride
T62252922-28-3
Adenine hydrochloride is a purine nucleobase and a chemical component of DNA and RNA. It is involved in cellular respiration, protein synthesis, and plays an important role in energy metabolism through high-energy molecules such as ATP, NAD, and FAD. It can be used to induce hyperuricemia and chronic kidney injury models.
- $30
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QTY
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