Diabetes Modeling

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Endocrinology and Metabolism Disease Modeling

Hyperuricemia Modeling

Diabetes Mellitus is a metabolic disorder caused by insufficient insulin secretion or impaired insulin action. Diabetes models are commonly induced using chemical agents (such as streptozotocin), high-fat/high-sugar diets, or genetic approaches to mimic pancreatic β-cell damage or insulin resistance. These models are widely used for studying β-cell function, investigating mechanisms of insulin resistance, and evaluating antidiabetic drugs.

Streptozotocin

U 9889, STZ, Streptozocin, NSC-85998

T150718883-66-4

Streptozotocin (Streptozocin, NSC-85998) is an antibiotic that enters pancreatic β-cells via the glucose transporter (GLUT2) and induces DNA methylation, leading to β-cell apoptosis. It is toxic to insulin-producing cells and commonly used to establish diabetic animal models. This product is unstable in solution and is recommended to be prepared freshly before use.

Antibacterial Antibiotic Autophagy DNA Alkylation DNA Alkylator/Crosslinker DNA/RNA Synthesis

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Cited

Fructose

Fructopyranose

T29547660-25-5

Fructose is a simple ketose monosaccharide widely found in many plants and commonly combines with glucose to form the disaccharide sucrose. It can be used to induce hyperuricemia and diabetes models.

Others

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Alloxan monohydrate

T78142244-11-3

Alloxan Monohydrate is a diabetogenic agent that acts as a proteasome inhibitor and induces diabetes in experimental animals by damaging the insulin-secreting β-cells in the pancreas. It is commonly used to establish diabetes models.

Proteasome

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Cyproheptadine hydrochloride

Periactin hydrochloride, Nuran, Cyproheptadine HCl, Anarexol

T6814969-33-5

Cyproheptadine hydrochloride is an effective orally active 5-HT2A receptor antagonist with antidepressant, anti-serotonin, and antiplatelet activities. It can be used for research on thromboembolic diseases and for the establishment of diabetes models.

5-HT Receptor

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Cyproheptadine

T60576129-03-3

Cyproheptadine is an orally active serotonin 5-HT2A receptor antagonist with multiple pharmacological properties including antidepressant, anti-serotonin, antiplatelet, and antithrombotic effects. Cyproheptadine is used as a research compound for investigating thromboembolic diseases, serotonergic signaling, and potential links between serotonin modulation and metabolic disorders such as diabetes.

5-HT Receptor

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