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Tags Endocrinology and Metabolism Disease Modeling

Aging Modeling

Aging is a gradual multi-system decline characterized by cellular senescence, immune dysfunction, and metabolic disorders. Common experimental models include naturally aged animals, D-galactose-induced models, and SAMP8 (senescence-accelerated mice). These models are used to study oxidative stress, mitochondrial function, epigenetic changes, and anti-aging intervention strategies.

D-Galactose
T059159-23-4
D-Galactose (Alpha-D-galactose) is an aldohexose that exists naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins and is converted enzymatically into D-glucose for metabolism or polysaccharides for storage. It accelerates senescence in invertebrates and mammals and has been used as a model for aging.
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Liothyronine
T16536893-02-3
Liothyronine (Tresitope) is an active form of thyroid hormone, binding to β1 thyroid hormone receptor (TRβ1), and activates its activity.
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