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Immunology and Inflammation Disease Modeling Immunology and Inflammation Disease ModelingExperimental autoimmune encephalomyelitis Modeling
Experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for studying multiple sclerosis (MS). It is induced in mice or rats by immunization with myelin-associated antigens such as myelin oligodendrocyte glycoprotein (MOG) or myelin basic protein (MBP), triggering immune-mediated inflammation in the central nervous system. The EAE model is valuable for investigating neuroimmune regulation, myelin repair, and anti-inflammatory immunotherapies.
MOG peptide (35-55), mouse, rat acetate
T7657L
MOG peptide (35-55), mouse, rat acetate, is a minor component of central nervous system myelin with encephalitogenic activity. It can induce CD4⁺ T cell proliferation and Th1-type immune responses, leading to relapsing-remitting demyelinating disease. It is commonly used to establish experimental autoimmune encephalomyelitis (EAE) models.
- $135
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Arachidonic acid
T4129506-32-1
Arachidonic acid (Immunocytophyt) is a polyunsaturated omega-6 essential fatty acid that serves as a major component of biological membranes and animal phospholipids. It is synthesized from dietary linoleic acid and acts as a precursor to lipid mediators such as prostaglandins, thromboxanes, and leukotrienes. Arachidonic acid can improve cognitive responses and cardiovascular function and is commonly used to induce paw edema models.
- $39
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Dextran
T110129004-54-0
Dextran (Dextran 40) inhibits platelet aggregation and coagulation factors, can partially replace whole blood during transfusion, and is commonly used as a plasma volume expander; it can also be used in paw edema models.
- $33
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MOG (35-55) mouse, rat
T7657149635-73-4
MOG (35-55) mouse, rat is a minor component of the central nervous system myelin with high brain specificity and strong immunogenicity. It can induce T and B cell responses, trigger relapsing-remitting neurological disorders with plaque-like demyelination, and is commonly used for inducing experimental autoimmune encephalomyelitis (EAE) models.
- $56
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κ-Carrageenan
T3849911114-20-8
κ-Carrageenan is a natural polymer predominantly found in red seaweeds that can serve as an effective carrier to deliver curcumin to cancer cells and induce apoptosis. It can also be used to induce paw swelling models and acts as a potential inflammatory agent that amplifies existing intestinal inflammation.
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PLP (190-209)
TP2616165549-59-7
PLP (190-209) is a peptide derived from proteolipid protein (PLP) and is widely used to induce experimental autoimmune encephalomyelitis (EAE) animal models.
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Arachidonic acid sodium salt
T845446610-25-9
Arachidonic acid sodium salt is a polyunsaturated omega-6 fatty acid that is a major component of biological membranes, serving as a substrate for various lipid mediators including prostaglandins (PG). It can improve cognitive responses and cardiovascular function, and can also be used to induce paw swelling models.
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MOG (35-55) TFA
TP1091
MOG (35-55) TFA is a minor component of central nervous system myelin with encephalitogenic activity. It can induce T cell proliferation, activate Th1 cytokine responses, and elicit high levels of IgG antibodies, leading to relapsing-remitting central nervous system disease characterized by extensive plaque-like demyelination. It is commonly used to induce experimental autoimmune encephalomyelitis (EAE) models.
- $121
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PLP (139-151)
TP1282131334-43-5
PLP (139-151) is an amino acid fragment from positions 139 to 151 of myelin proteolipid protein (PLP), which is used to induce the relapsing-remitting experimental autoimmune encephalomyelitis (RR-EAE) model.
- $85
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BR103
T706591434873-26-3
BR103 is a metabolically stable C3aR-selective agonist that can be used to assess the ligand affinity of G protein-coupled receptors and to induce paw edema models.
- $1,520
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