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Immunology and Inflammation Disease ModelingOther Related Immunology and Inflammation Disease Modeling
In addition to the common inflammatory diseases mentioned above, models of inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), Sjögren’s syndrome, and graft-versus-host disease (GVHD) are also critical in immunological research. These models are established through genetic engineering, chemical induction, and immune activation methods, facilitating the study of inflammatory signaling regulation, immune tolerance mechanisms, and preclinical screening of novel immunomodulatory agents.
Phorbol 12-myristate 13-acetate
Cited
TQ019816561-29-8
Phorbol 12-myristate 13-acetate (PMA), a member of the phorbol ester group of natural products, activates PKC, SphK, and NF-κB, and induces THP1 cell differentiation.
- $44
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CitedDoxorubicin hydrochloride Cited
T102025316-40-9
Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I II (IC50=0.8 2.67 μM). Doxorubicin hydrochloride exhibits cytotoxicity and antitumor activity. Doxorubicin hydrochloride reduces the phosphorylation of AMPK and its downstream target protein acetyl coenzyme A carboxylase, and induces apoptosis and autophagy.
- $34
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CitedHygromycin B Cited
T102231282-04-9
Hygromycin B (Hygrovetine) is an aminoglycoside antibiotic that inhibits protein synthesis by interfering with translocation and causing mistranslation of the 70S ribosome. Hygromycin B can be used to screen prokaryotic or eukaryotic cells transfected with hph or hyg resistance genes.
- $35
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CitedDextran sulfate sodium salt (MW 4500-5500) Cited
T136479011-18-1
Dextran sulfate sodium salt (MW 4500-5500) is an anhydrous glucose polymer with a molecular weight range of 4500-5500. Dextran sulfate sodium salt (MW 4500-5500) inhibits human immunodeficiency virus replication by preventing viral adsorption to host cells. Dextran sulfate sodium salt (MW 4500-5500) induces inflammation mainly in the colon. It can destroy the integrity of the intestinal mucosal barrier through the high negative charge caused by sulfate groups, leading to intestinal barrier damage, macrophage dysfunction, and bacterial flora disorder.
- $33
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CitedTacrolimus Cited
T2144104987-11-3
Tacrolimus (Fujimycin) can bind FKBP12 to form a high-affinity complex (Ki: 0.2 nM) which inhibits the activity of the calcium calmodulin-dependent protein phosphatase.
- $38
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CitedD(+)-Galactosamine hydrochloride
T39991772-03-8
D(+)-Galactosamine hydrochloride (D-Galactosamine HCl) hepatotoxicity is associated with endotoxin sensitivity and mediated by lymphoreticular cells in mice.
- $42
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Progesterone Cited
T047857-83-0
Progesterone (Pregn-4-ene-3,20-dione) is the major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production.
- $38
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CitedLithocholic acid Cited
T2202434-13-9
Lithocholic acid (3α-Hydroxy-5β-cholanic acid) is a bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic.
- $35
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CitedLiothyronine Cited
T16536893-02-3
Liothyronine (Tresitope) is an active form of thyroid hormone, binding to β1 thyroid hormone receptor (TRβ1), and activates its activity.
- $36
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CitedOxazolone
T509515646-46-5
Oxazolone has been used as a haptenizing agent to induce inflammatory responses in intestinal tissue of adult zebrafish and as a model for gene expression studies in two forms of inflammatory bowel disease, such as Crohn's disease and ulcerative colitis.
- $29
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DMBA
T3669657-97-6
DMBA (7,12-Dimethylbenz[a]anthracene) induces leukemia, hepatocellular carcinoma, and mammary carcinoma in rats, and programmed cell death (apoptosis) in B-cell lymphomas in A20.1 mice.
- $30
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Cysteamine hydrochloride
T6460156-57-0
Cysteamine hydrochloride (Thioethanolamine Hydrochloride) is an agent for the treatment of nephropathic cystinosis and an antioxidant.
- $29
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L-Homocysteine
T193926027-13-0
L-Homocysteine is a biological thiol associated with various diseases and conditions. It is a marker for atherosclerosis and exacerbates intestinal inflammation in IBD by promoting 5-LOX and COX-2.
- $30
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Zymosan A
T7810158856-93-2
Zymosan A, a polysaccharide from Saccharomyces cerevisiae (brewer's yeast), is a TLR2 agonist that promotes regeneration of ISCs from intestinal stem cells after radiation injury by up-regulating ASCL2 through the TLR2 signaling pathway and the Wnt signaling pathway.Zymosan A stimulates immune responses and induces inflammation , anorexia and elevated body temperature, and also inhibits the gap junction protein connexin 43 in human corneal fibroblasts and causes corneal stromal damage.
- $35
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Sodium thioglycolate
T8530367-51-1
Sodium thioglycolate is a disulfide reducing agent
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