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Paw Edema Modeling

The paw edema model is a classic acute inflammation model commonly induced by carrageenan or formalin injection into the paw of mice or rats. It is widely used to evaluate the efficacy of anti-inflammatory agents. Due to its simplicity, high reproducibility, and sensitivity, this model is frequently employed in the pharmacological assessment of non-steroidal anti-inflammatory drugs (NSAIDs) and natural products.

Arachidonic acid
T4129506-32-1
Arachidonic acid (Immunocytophyt) is a polyunsaturated omega-6 essential fatty acid that serves as a major component of biological membranes and animal phospholipids. It is synthesized from dietary linoleic acid and acts as a precursor to lipid mediators such as prostaglandins, thromboxanes, and leukotrienes. Arachidonic acid can improve cognitive responses and cardiovascular function and is commonly used to induce paw edema models.
  • $39
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Dextran
T110129004-54-0
Dextran (Dextran 40) inhibits platelet aggregation and coagulation factors, can partially replace whole blood during transfusion, and is commonly used as a plasma volume expander; it can also be used in paw edema models.
  • $33
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κ-Carrageenan
T3849911114-20-8
κ-Carrageenan is a natural polymer predominantly found in red seaweeds that can serve as an effective carrier to deliver curcumin to cancer cells and induce apoptosis. It can also be used to induce paw swelling models and acts as a potential inflammatory agent that amplifies existing intestinal inflammation.
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Arachidonic acid sodium salt
T845446610-25-9
Arachidonic acid sodium salt is a polyunsaturated omega-6 fatty acid that is a major component of biological membranes, serving as a substrate for various lipid mediators including prostaglandins (PG). It can improve cognitive responses and cardiovascular function, and can also be used to induce paw swelling models.
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8-10 weeks
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BR103
T706591434873-26-3
BR103 is a metabolically stable C3aR-selective agonist that can be used to assess the ligand affinity of G protein-coupled receptors and to induce paw edema models.
  • $1,520
6-8 weeks
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