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Immunology and Inflammation Disease ModelingPeptic ulcer disease Modeling
Peptic ulcer disease is primarily caused by gastric acid, Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs (NSAIDs), or psychological stress, leading to mucosal damage in the stomach or duodenum. Common modeling methods include chemical injury (e.g., ethanol, indomethacin, aspirin) and pylorus ligation. These models are widely used to study mucosal protective mechanisms and to screen pro-healing agents and anti-ulcer compounds.
Aspirin
Cited
T000550-78-2
Aspirin (Acetylsalicylic Acid) is a COX inhibitor that inhibits COX1 and COX2 (IC50=5 210 μg mL) with selective, irreversible, and oral activity. Aspirin is also a histone deacetylase inhibitor that up-regulates the cell cycle blocking protein, p21. Aspirin has a variety of activities. Aspirin has anti-inflammatory, antipyretic and analgesic, and antiplatelet aggregation activities.
- $31
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CitedIndomethacin sodium hydrate
T2234674252-25-8
Indomethacin sodium hydrate (Indometacin sodium hydrate) is an orally active, competitive and reversible COX1 2 inhibitor with potential anti-inflammatory activity in induced migraines, induced gastrointestinal injuries, and may be used in studies of increased intracranial pressure secondary to severe traumatic brain injury and rheumatoid arthritis in adults.
- $40
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Histamine
T096551-45-6
Histamine (Ergamine) is an amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
- $36
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Indomethacin Cited
T045853-86-1
Indomethacin (Indomethacin) is a COX1 and COX2 inhibitor (IC50=18 26 nM) with blood-brain barrier permeability and non-selectivity. Indomethacin is a non-steroidal anti-inflammatory agent with anti-tumor and anti-infective activity.
- $37
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CitedReserpine
T079150-55-5
Reserpine (Serpalan) is an alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
- $36
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Histamine dihydrochloride
T653456-92-8
Histamine dihydrochloride (Ceplene) is dihydrochloride form of Histamine. Histamine is an organic nitrogen compound which is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.
- $30
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Histamine Phosphate
T653551-74-1
Histamine Phosphate (Histamine acid phosphate) acts directly on the blood vessels to dilate arteries and capillaries mediated by both H 1- and H 2-receptors.
- $48
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indomethacin sodium
T616067681-54-1
Indomethacin sodium, a powerful and orally active inhibitor of COX1 2, exhibits IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Apart from its potent anti-inflammatory effects, this compound possesses notable anticancer and anti-infective activities. Since it has such versatile attributes, it finds useful applicability in cancer, inflammation, and viral infection research [1] [2] [3].
- $1,520
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Lithium acetylsalicylate
T32795552-98-7
Lithium acetylsalicylate is a bioactive chemical.
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