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Immunology and Inflammation Disease Modeling Immunology and Inflammation Disease ModelingPancreatitis Modeling
Pancreatitis, including both acute and chronic forms, involves complex pathogenic mechanisms such as premature activation of pancreatic enzymes, release of inflammatory cytokines, and oxidative stress. Commonly used animal models include L-arginine induction, bile duct ligation, and alcohol-induced methods. These models are valuable for investigating pancreatic tissue injury mechanisms, evaluating anti-inflammatory therapies, and exploring intervention strategies for multiple organ dysfunction.
Ceruletide
T1493217650-98-5
Ceruletide is a decapeptide that serves as a safe and effective cholecystokinin receptor agonist, exerting a direct spasmogenic effect on the gallbladder muscle and bile ducts, and is commonly used to establish pancreatitis models.
- $45
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QTY
Taurocholic acid
TN225981-24-3
Taurocholic acid (N-Choloyltaurine) is a bile acid involved in fat emulsification, possessing notable biological and immunomodulatory activities. It can inhibit bile duct injury induced by hepatic artery ligation by upregulating VEGF-A expression and protect cholangiocytes from TNF-α-induced damage via a PI3K-mediated pathway, and is commonly used to induce pancreatitis models.
- $55
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QTY
L-Arginine
T3S036474-79-3
L-Arginine (L-Arg) is a substrate of endothelial nitric oxide synthase (eNOS). It is transported into vascular smooth muscle cells via the cationic amino acid transporter family, where it is metabolized into nitric oxide (NO), polyamines, or L-proline. L-Arginine is an effective vasodilator and is commonly used to induce experimental acute pancreatitis.
- $31
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Sodium taurocholate
TWA2417145-42-6
Sodium taurocholate is a biologically active compound that can inhibit bile duct injury induced by hepatic artery ligation by upregulating VEGF-A expression. It also exhibits immunomodulatory effects and can be used to induce pancreatitis models.
- $50
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Taurocholic acid sodium salt hydrate
T1138345909-26-4
Taurocholic acid sodium salt hydrate is a bile acid sodium salt hydrate that participates in fat emulsification and can be used to establish pancreatitis models.
- $42
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L-Arginine hydrochloride
T06701119-34-2
L-Arginine hydrochloride serve as substrates and nitrogen donors for endothelial nitric oxide synthase (eNOS) to produce nitric oxide (NO). They are transported into vascular smooth muscle cells via cationic amino acid transporters, where they are metabolized into NO, polyamines, or L-proline. As effective vasodilators, they are commonly used to induce experimental acute pancreatitis models.
- $33
Size
QTY
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