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Wee1

Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe. Wee1 has a molecular mass of 96 kDa and is a key regulator of cell cycle progression. It influences cell size by inhibiting the entry into mitosis, through inhibiting Cdk1. Wee1 has homologues in many other organisms, including mammals.
Cat. No. Product name CAS No. Purity Chemical Structure
T41163 ZNL 02-096 2414418-49-6 98%
ZNL 02-096 is a rapid and selective degrader of Wee1 (IC50=3.58 nM).ZNL 02-096 selectively degrades Wee1 at submolar concentrations without damaging PLK1, a seco...
T9643 ZN-c3 2376146-48-2 98%
ZN-c3 is a potent and selective Wee1 inhibitor with balanced potency, ADME, and pharmacokinetic properties.
T6931 PD0166285 185039-89-8 98%
PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator.
T2077 Adavosertib 955365-80-7 98%
MK-1775 is a small molecule inhibitor of the checkpoint kinase WEE1 (IC50: 5.2 nM). It hinders the G2 DNA damage checkpoint.
T9864 Debio-0123 2243882-74-6 98%
WEE1-IN-5 (Debio 0123) is a potent, orally available and highly specific WEE1 inhibitor with an IC 50 in the low nanomolar range. WEE1-IN-5 inhibits phospho-CDC2...
T60889 RP-6306 2719793-90-3 98%
RP-6306 is a potent, selective and orally active PKMYT1 inhibitor (IC50= 14 nM). RP-6306 exhibits a high degree of selectivity for PKMYT1 over other kinases in c...
T8916 WEE1-IN-3 2272976-28-8 98%
JUN76288 is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.
T9966 GSK-1520489A 1042433-41-9 98%
GSK-1520489A is an active PKMYT1 inhibitor.
ZNL 02-096
T41163
ZNL 02-096 is a rapid and selective degrader of Wee1 (IC50=3.58 nM).ZNL 02-096 selectively degrades Wee1 at submolar concentrations without damaging PLK1, a seco...
ZN-c3
T9643
ZN-c3 is a potent and selective Wee1 inhibitor with balanced potency, ADME, and pharmacokinetic properties.
PD0166285
T6931
PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator.
Adavosertib
T2077
MK-1775 is a small molecule inhibitor of the checkpoint kinase WEE1 (IC50: 5.2 nM). It hinders the G2 DNA damage checkpoint.
Debio-0123
T9864
WEE1-IN-5 (Debio 0123) is a potent, orally available and highly specific WEE1 inhibitor with an IC 50 in the low nanomolar range. WEE1-IN-5 inhibits phospho-CDC2...
RP-6306
T60889
RP-6306 is a potent, selective and orally active PKMYT1 inhibitor (IC50= 14 nM). RP-6306 exhibits a high degree of selectivity for PKMYT1 over other kinases in c...
WEE1-IN-3
T8916
JUN76288 is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.
GSK-1520489A
T9966
GSK-1520489A is an active PKMYT1 inhibitor.