Home Tools
Log in
Cart

S1P Receptor

The sphingosine-1-phosphate receptors are a class of G protein-coupled receptors that are targets of the lipid signalling molecule Sphingosine-1-phosphate (S1P). They are divided into five subtypes: S1PR1, S1PR2, S1PR3, S1PR4 and S1PR5. .
Cat. No. Product name CAS No. Purity Chemical Structure
T12927 SK1-IN-1 1218816-71-7 98%
SK1-IN-1 is a potent inhibitor of sphingosine kinase 1 (SPHK1)(IC50 of 58 nM).
T10385 ASP-4058 952565-91-2 98%
ASP-4058 is a selective and oral bioactive agonist for S1P1 and S1P5. It ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety pro...
T17237 VPC 23019 449173-19-7 98%
VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pE...
T6085 PF-543 1415562-82-1 98%
PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
T12436 PF-543 Citrate 1415562-83-2 98%
PF-543 Citrate is an inhibitor of sphingosine-competitive SPHK1(IC50 of 2 nM ).
T11747 KD-3010 934760-92-6 98%
KD-3010 is a orally, potent active, and selective PPARδ agonist.
T38294 4-Deoxypyridoxine hydrochloride 148-51-6 98%
4-Deoxypyridoxine (4-DPD) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in...
T27710 K6PC-5 756875-51-1 98%
K6PC-5, a ceramide derivative, is a sphingosine kinase 1(SPHK1) activator and elicites a rapid transient increase in intracellular calcium levels. K6PC-5 has the...
T22697 CS 2100 913827-99-3 98%
S1P1 agonist
TQ0138 K145 hydrochloride 1449240-68-9 98%
K145 is a specific inhibitor of SphK2 (IC50: 4.30 μM), while no inhibition of SphK1 at concentrations up to 10 μM.
T9992 WAY-272077 1415662-57-5 98%
WAY-272077 is a sphingosine kinase inhibitor with anti-inflammatory, antitumor and hemostatic effects.
T2026 CYM5442 1094042-01-9 96.65%
CYM5442 is an S1P agonist, targeting to Sphingosine.
T10761 Ceranib-2 1402830-75-4 97.49%
Ceranib-2 is an inhibitor of ceramidase with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 decreases levels of sphingosine and S1P, induces cell apoptosis and exhib...
T7360 GSK2018682 1034688-30-6 97.78%
GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).
T3258 Ponesimod 854107-55-4 98.01%
Ponesimod is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist that acts as a functional antagonist, with potential immunomodulating a...
T9199 GLPG2938 2130996-00-6 98.1%
GLPG2938 is a potent and selective antagonist of S1P2.
T3961 CYM-5541 945128-26-7 98.39%
CYM-5541 is a selective and allosteric S1P3 receptor agonist.
T22703 CYM-5520 1449747-00-5 98.72%
noncompetitive allosteric agonist of S1P2
T15629 JTE-013 383150-41-2 98.87%
JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 n...
T9014 SKI-178 1259484-97-3 99.2%
SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic ...
SK1-IN-1
T12927
SK1-IN-1 is a potent inhibitor of sphingosine kinase 1 (SPHK1)(IC50 of 58 nM).
ASP-4058
T10385
ASP-4058 is a selective and oral bioactive agonist for S1P1 and S1P5. It ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety pro...
VPC 23019
T17237
VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pE...
PF-543
T6085
PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
PF-543 Citrate
T12436
PF-543 Citrate is an inhibitor of sphingosine-competitive SPHK1(IC50 of 2 nM ).
KD-3010
T11747
KD-3010 is a orally, potent active, and selective PPARδ agonist.
4-Deoxypyridoxine hydrochloride
T38294
4-Deoxypyridoxine (4-DPD) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in...
K6PC-5
T27710
K6PC-5, a ceramide derivative, is a sphingosine kinase 1(SPHK1) activator and elicites a rapid transient increase in intracellular calcium levels. K6PC-5 has the...
CS 2100
T22697
S1P1 agonist
K145 hydrochloride
TQ0138
K145 is a specific inhibitor of SphK2 (IC50: 4.30 μM), while no inhibition of SphK1 at concentrations up to 10 μM.
WAY-272077
T9992
WAY-272077 is a sphingosine kinase inhibitor with anti-inflammatory, antitumor and hemostatic effects.
CYM5442
T2026
CYM5442 is an S1P agonist, targeting to Sphingosine.
Ceranib-2
T10761
Ceranib-2 is an inhibitor of ceramidase with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 decreases levels of sphingosine and S1P, induces cell apoptosis and exhib...
GSK2018682
T7360
GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).
Ponesimod
T3258
Ponesimod is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist that acts as a functional antagonist, with potential immunomodulating a...
GLPG2938
T9199
GLPG2938 is a potent and selective antagonist of S1P2.
CYM-5541
T3961
CYM-5541 is a selective and allosteric S1P3 receptor agonist.
CYM-5520
T22703
noncompetitive allosteric agonist of S1P2
JTE-013
T15629
JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 n...
SKI-178
T9014
SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic ...
1 2 3