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S1P Receptor

The sphingosine-1-phosphate receptors are a class of G protein-coupled receptors that are targets of the lipid signalling molecule Sphingosine-1-phosphate (S1P). They are divided into five subtypes: S1PR1, S1PR2, S1PR3, S1PR4 and S1PR5. .
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T21500 Sphingosine-1-phosphate 26993-30-6 98%
Sphingosine-1-phosphate
Sphingosine-1-phosphate (S1P) is an agonist for S1P1-5 receptors and a ligand for GPR3, GPR6, GPR12.Sphingosine-1-phosphate is an intracellular second messenger ...
T17237 VPC 23019 449173-19-7 98%
VPC 23019
VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pE...
T12927 SK1-IN-1 1218816-71-7 98%
SK1-IN-1
SK1-IN-1 is a potent inhibitor of sphingosine kinase 1 (SPHK1)(IC50 of 58 nM).
T12436 PF-543 Citrate 1415562-83-2 98%
PF-543 Citrate
PF-543 Citrate is an inhibitor of sphingosine-competitive SPHK1(IC50 of 2 nM ).
T6673 SKI II 312636-16-1 99.97%
SKI II
SKI II (SphK-I2) is a highly selective and non-ATP-competitive S1P receptor inhibitor (IC50: 0.5 μM) while exhibiting no inhibitory action on other kinases inclu...
T4031 S1p receptor agonist 1 1514888-56-2 99.94%
S1p receptor agonist 1
S1p receptor agonist 1 (S1p-receptor-agonist-1) is an S1P receptor agonist.
T8840 PF-543 hydrochloride 1706522-79-3 99.92%
PF-543 hydrochloride
PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isofo...
TQ0198 Phorbol 12-myristate 13-acetate 16561-29-8 99.87%
Phorbol 12-myristate 13-acetate
Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB. Phorbol 12-myristate 13...
TQ0064 Peretinoin 81485-25-8 99.86%
Peretinoin
Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.
T27864 LX-2931 948840-25-3 99.83%
LX-2931
LX-2931(LX-3305) is a sphingosine-1-phosphate cleavage enzyme (S1P) inhibitor for the treatment of rheumatoid arthritis.
T7939 Fingolimod 162359-55-9 99.76%
Fingolimod
Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).
T6923 Ozanimod 1306760-87-1 99.74%
Ozanimod
Ozanimod (RPC-1063) (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative...
T17183 TY-52156 934369-14-9 99.73%
TY-52156
TY-52156 is an effective and selective S1P3 receptor antagonist (Ki: 110 nM).
T2539 Fingolimod hydrochloride 162359-56-0 99.69%
Fingolimod hydrochloride
Fingolimod hydrochloride (FTY720) , a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
T10305 Amiselimod hydrochloride 942398-84-7 99.68%
Amiselimod hydrochloride
Amiselimod hydrochloride (MT-1303 hydrochloride) is a sphingosine 1-phosphate receptor-1 (S1P1) modulator.
T8461 SKI V 24418-86-8 99.62%
SKI V
SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM), induces...
T2171 SEW​2871 256414-75-2 99.62%
SEW​2871
SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies r...
T10385 ASP-4058 952565-91-2 99.51%
ASP-4058
ASP-4058 is a selective, safe, and orally active second-generation agonist of sphingosine phosphate receptors 1 and 5 (S1P1 and S1P5).ASP-4058 ameliorates experi...
T38826 Vibozilimod 1403232-33-6 99.47%
Vibozilimod
Vibozilimod (SCD-044) is S1P receptor-1 (S1PR1) agonist .
T4658 MHP 1104874-94-3 99.45%
MHP
MHP (Methyl caprooyl tyrosinate) is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production in KC.
Sphingosine-1-phosphate
T21500
Sphingosine-1-phosphate (S1P) is an agonist for S1P1-5 receptors and a ligand for GPR3, GPR6, GPR12.Sphingosine-1-phosphate is an intracellular second messenger ...
VPC 23019
T17237
VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pE...
SK1-IN-1
T12927
SK1-IN-1 is a potent inhibitor of sphingosine kinase 1 (SPHK1)(IC50 of 58 nM).
PF-543 Citrate
T12436
PF-543 Citrate is an inhibitor of sphingosine-competitive SPHK1(IC50 of 2 nM ).
SKI II
T6673
SKI II (SphK-I2) is a highly selective and non-ATP-competitive S1P receptor inhibitor (IC50: 0.5 μM) while exhibiting no inhibitory action on other kinases inclu...
S1p receptor agonist 1
T4031
S1p receptor agonist 1 (S1p-receptor-agonist-1) is an S1P receptor agonist.
PF-543 hydrochloride
T8840
PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isofo...
Phorbol 12-myristate 13-acetate
TQ0198
Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB. Phorbol 12-myristate 13...
Peretinoin
TQ0064
Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR.
LX-2931
T27864
LX-2931(LX-3305) is a sphingosine-1-phosphate cleavage enzyme (S1P) inhibitor for the treatment of rheumatoid arthritis.
Fingolimod
T7939
Fingolimod (FTY-720A) is an antagonist of sphingosine 1-phosphate (S1P) (IC50 of 0.033 nM in K562 and NK cells).
Ozanimod
T6923
Ozanimod (RPC-1063) (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative...
TY-52156
T17183
TY-52156 is an effective and selective S1P3 receptor antagonist (Ki: 110 nM).
Fingolimod hydrochloride
T2539
Fingolimod hydrochloride (FTY720) , a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).
Amiselimod hydrochloride
T10305
Amiselimod hydrochloride (MT-1303 hydrochloride) is a sphingosine 1-phosphate receptor-1 (S1P1) modulator.
SKI V
T8461
SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM), induces...
SEW​2871
T2171
SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies r...
ASP-4058
T10385
ASP-4058 is a selective, safe, and orally active second-generation agonist of sphingosine phosphate receptors 1 and 5 (S1P1 and S1P5).ASP-4058 ameliorates experi...
Vibozilimod
T38826
Vibozilimod (SCD-044) is S1P receptor-1 (S1PR1) agonist .
MHP
T4658
MHP (Methyl caprooyl tyrosinate) is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production in KC.
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TargetMol