S1P Receptor

The sphingosine-1-phosphate receptors are a class of G protein-coupled receptors that are targets of the lipid signalling molecule Sphingosine-1-phosphate (S1P). They are divided into five subtypes: S1PR1, S1PR2, S1PR3, S1PR4 and S1PR5. .

Cat. No.	Product name	CAS No.	Purity
T12927	SK1-IN-1	1218816-71-7	98%
T12927	SK1-IN-1 is a potent inhibitor of sphingosine kinase 1 (SPHK1)(IC50 of 58 nM).
T10385	ASP-4058	952565-91-2	98%
T10385	ASP-4058 is a selective and oral bioactive agonist for S1P1 and S1P5. It ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety pro...
T17237	VPC 23019	449173-19-7	98%
T17237	VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pE...
T6085	PF-543	1415562-82-1	98%
T6085	PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
T12436	PF-543 Citrate	1415562-83-2	98%
T12436	PF-543 Citrate is an inhibitor of sphingosine-competitive SPHK1(IC50 of 2 nM ).
T11747	KD-3010	934760-92-6	98%
T11747	KD-3010 is a orally, potent active, and selective PPARδ agonist.
T38294	4-Deoxypyridoxine hydrochloride	148-51-6	98%
T38294	4-Deoxypyridoxine (4-DPD) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in...
T27710	K6PC-5	756875-51-1	98%
T27710	K6PC-5, a ceramide derivative, is a sphingosine kinase 1(SPHK1) activator and elicites a rapid transient increase in intracellular calcium levels. K6PC-5 has the...
T22697	CS 2100	913827-99-3	98%
T22697	S1P1 agonist
TQ0138	K145 hydrochloride	1449240-68-9	98%
TQ0138	K145 is a specific inhibitor of SphK2 (IC50: 4.30 μM), while no inhibition of SphK1 at concentrations up to 10 μM.
T9992	WAY-272077	1415662-57-5	98%
T9992	WAY-272077 is a sphingosine kinase inhibitor with anti-inflammatory, antitumor and hemostatic effects.
T2026	CYM5442	1094042-01-9	96.65%
T2026	CYM5442 is an S1P agonist, targeting to Sphingosine.
T10761	Ceranib-2	1402830-75-4	97.49%
T10761	Ceranib-2 is an inhibitor of ceramidase with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 decreases levels of sphingosine and S1P, induces cell apoptosis and exhib...
T7360	GSK2018682	1034688-30-6	97.78%
T7360	GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).
T3258	Ponesimod	854107-55-4	98.01%
T3258	Ponesimod is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist that acts as a functional antagonist, with potential immunomodulating a...
T9199	GLPG2938	2130996-00-6	98.1%
T9199	GLPG2938 is a potent and selective antagonist of S1P2.
T3961	CYM-5541	945128-26-7	98.39%
T3961	CYM-5541 is a selective and allosteric S1P3 receptor agonist.
T22703	CYM-5520	1449747-00-5	98.72%
T22703	noncompetitive allosteric agonist of S1P2
T15629	JTE-013	383150-41-2	98.87%
T15629	JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 n...
T9014	SKI-178	1259484-97-3	99.2%
T9014	SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic ...