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S1P Receptor

The sphingosine-1-phosphate receptors are a class of G protein-coupled receptors that are targets of the lipid signalling molecule Sphingosine-1-phosphate (S1P). They are divided into five subtypes: S1PR1, S1PR2, S1PR3, S1PR4 and S1PR5. .
Cat. No. Product name CAS No. Purity Chemical Structure
T12436 PF-543 Citrate 1415562-83-2 98%
PF-543 Citrate is an inhibitor of sphingosine-competitive SPHK1(IC50 of 2 nM ).
T12927 SK1-IN-1 1218816-71-7 98%
SK1-IN-1 is a potent inhibitor of sphingosine kinase 1 (SPHK1)(IC50 of 58 nM).
T17237 VPC 23019 449173-19-7 98%
VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pE...
T11747 KD-3010 934760-92-6 98%
KD-3010 is a orally, potent active, and selective PPARδ agonist.
T6085 PF-543 1415562-82-1 98%
PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
T9992 WAY-272077 1415662-57-5 98%
WAY-272077 is a sphingosine kinase inhibitor with anti-inflammatory, antitumor and hemostatic effects.
T63047 SLP9101555 T63047 98%
SLP9101555 is a potent and selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM.SLP9101555 has a high affinity for SphK2, which is 200-fold higher...
T38294 4-Deoxypyridoxine hydrochloride 148-51-6 98%
4-Deoxypyridoxine (4-DPD) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in...
T2026 CYM5442 1094042-01-9 98%
CYM5442 is an S1P agonist, targeting to Sphingosine.
T10761 Ceranib-2 1402830-75-4 98%
Ceranib-2 is an inhibitor of ceramidase with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 decreases levels of sphingosine and S1P, induces cell apoptosis and exhib...
T7360 GSK2018682 1034688-30-6 98%
GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).
T16128 MP-A08 219832-49-2 98%
MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 (Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, respectiv...
T9199 GLPG2938 2130996-00-6 98%
GLPG2938 is a potent and selective antagonist of S1P2.
T22697 CS 2100 913827-99-3 98%
S1P1 agonist
T3258 Ponesimod 854107-55-4 98%
Ponesimod is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist that acts as a functional antagonist, with potential immunomodulating a...
T22101 ML-031 852230-33-2 98%
ML-031 activated S1P2 with an EC50 value of 1 μM in an S1P reporter assay.
T3961 CYM-5541 945128-26-7 98%
CYM-5541 is a selective and allosteric S1P3 receptor agonist.
T27710 K6PC-5 756875-51-1 98%
K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. W...
T12437 PF429242 dihydrochloride 2248666-66-0 98%
PF429242 dihydrochloride is a reversible and competitive inhibitor of S1P (IC50 of 175 nM).
T22703 CYM-5520 1449747-00-5 98%
noncompetitive allosteric agonist of S1P2
PF-543 Citrate
T12436
PF-543 Citrate is an inhibitor of sphingosine-competitive SPHK1(IC50 of 2 nM ).
SK1-IN-1
T12927
SK1-IN-1 is a potent inhibitor of sphingosine kinase 1 (SPHK1)(IC50 of 58 nM).
VPC 23019
T17237
VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pE...
KD-3010
T11747
KD-3010 is a orally, potent active, and selective PPARδ agonist.
PF-543
T6085
PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
WAY-272077
T9992
WAY-272077 is a sphingosine kinase inhibitor with anti-inflammatory, antitumor and hemostatic effects.
SLP9101555
T63047
SLP9101555 is a potent and selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM.SLP9101555 has a high affinity for SphK2, which is 200-fold higher...
4-Deoxypyridoxine hydrochloride
T38294
4-Deoxypyridoxine (4-DPD) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in...
CYM5442
T2026
CYM5442 is an S1P agonist, targeting to Sphingosine.
Ceranib-2
T10761
Ceranib-2 is an inhibitor of ceramidase with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 decreases levels of sphingosine and S1P, induces cell apoptosis and exhib...
GSK2018682
T7360
GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).
MP-A08
T16128
MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 (Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, respectiv...
GLPG2938
T9199
GLPG2938 is a potent and selective antagonist of S1P2.
CS 2100
T22697
S1P1 agonist
Ponesimod
T3258
Ponesimod is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist that acts as a functional antagonist, with potential immunomodulating a...
ML-031
T22101
ML-031 activated S1P2 with an EC50 value of 1 μM in an S1P reporter assay.
CYM-5541
T3961
CYM-5541 is a selective and allosteric S1P3 receptor agonist.
K6PC-5
T27710
K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. W...
PF429242 dihydrochloride
T12437
PF429242 dihydrochloride is a reversible and competitive inhibitor of S1P (IC50 of 175 nM).
CYM-5520
T22703
noncompetitive allosteric agonist of S1P2
1 2 3
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