T12436 |
PF-543 Citrate
|
1415562-83-2
|
98%
|
|
PF-543 Citrate is an inhibitor of sphingosine-competitive SPHK1(IC50 of 2 nM ).
|
T12927 |
SK1-IN-1
|
1218816-71-7
|
98%
|
|
SK1-IN-1 is a potent inhibitor of sphingosine kinase 1 (SPHK1)(IC50 of 58 nM).
|
T17237 |
VPC 23019
|
449173-19-7
|
98%
|
|
VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pE...
|
T11747 |
KD-3010
|
934760-92-6
|
98%
|
|
KD-3010 is a orally, potent active, and selective PPARδ agonist.
|
T6085 |
PF-543
|
1415562-82-1
|
98%
|
|
PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
|
T9992 |
WAY-272077
|
1415662-57-5
|
98%
|
|
WAY-272077 is a sphingosine kinase inhibitor with anti-inflammatory, antitumor and hemostatic effects.
|
T63047 |
SLP9101555
|
T63047
|
98%
|
|
SLP9101555 is a potent and selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM.SLP9101555 has a high affinity for SphK2, which is 200-fold higher...
|
T38294 |
4-Deoxypyridoxine hydrochloride
|
148-51-6
|
98%
|
|
4-Deoxypyridoxine (4-DPD) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in...
|
T2026 |
CYM5442
|
1094042-01-9
|
98%
|
|
CYM5442 is an S1P agonist, targeting to Sphingosine.
|
T10761 |
Ceranib-2
|
1402830-75-4
|
98%
|
|
Ceranib-2 is an inhibitor of ceramidase with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 decreases levels of sphingosine and S1P, induces cell apoptosis and exhib...
|
T7360 |
GSK2018682
|
1034688-30-6
|
98%
|
|
GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).
|
T16128 |
MP-A08
|
219832-49-2
|
98%
|
|
MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 (Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, respectiv...
|
T9199 |
GLPG2938
|
2130996-00-6
|
98%
|
|
GLPG2938 is a potent and selective antagonist of S1P2.
|
T22697 |
CS 2100
|
913827-99-3
|
98%
|
|
S1P1 agonist
|
T3258 |
Ponesimod
|
854107-55-4
|
98%
|
|
Ponesimod is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist that acts as a functional antagonist, with potential immunomodulating a...
|
T22101 |
ML-031
|
852230-33-2
|
98%
|
|
ML-031 activated S1P2 with an EC50 value of 1 μM in an S1P reporter assay.
|
T3961 |
CYM-5541
|
945128-26-7
|
98%
|
|
CYM-5541 is a selective and allosteric S1P3 receptor agonist.
|
T27710 |
K6PC-5
|
756875-51-1
|
98%
|
|
K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. W...
|
T12437 |
PF429242 dihydrochloride
|
2248666-66-0
|
98%
|
|
PF429242 dihydrochloride is a reversible and competitive inhibitor of S1P (IC50 of 175 nM).
|
T22703 |
CYM-5520
|
1449747-00-5
|
98%
|
|
noncompetitive allosteric agonist of S1P2
|