T12927 |
SK1-IN-1
|
1218816-71-7
|
98%
|
|
SK1-IN-1 is a potent inhibitor of sphingosine kinase 1 (SPHK1)(IC50 of 58 nM).
|
T10385 |
ASP-4058
|
952565-91-2
|
98%
|
|
ASP-4058 is a selective and oral bioactive agonist for S1P1 and S1P5. It ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety pro...
|
T17237 |
VPC 23019
|
449173-19-7
|
98%
|
|
VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pE...
|
T6085 |
PF-543
|
1415562-82-1
|
98%
|
|
PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
|
T12436 |
PF-543 Citrate
|
1415562-83-2
|
98%
|
|
PF-543 Citrate is an inhibitor of sphingosine-competitive SPHK1(IC50 of 2 nM ).
|
T11747 |
KD-3010
|
934760-92-6
|
98%
|
|
KD-3010 is a orally, potent active, and selective PPARδ agonist.
|
T38294 |
4-Deoxypyridoxine hydrochloride
|
148-51-6
|
98%
|
|
4-Deoxypyridoxine (4-DPD) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in...
|
T27710 |
K6PC-5
|
756875-51-1
|
98%
|
|
K6PC-5, a ceramide derivative, is a sphingosine kinase 1(SPHK1) activator and elicites a rapid transient increase in intracellular calcium levels. K6PC-5 has the...
|
T22697 |
CS 2100
|
913827-99-3
|
98%
|
|
S1P1 agonist
|
TQ0138 |
K145 hydrochloride
|
1449240-68-9
|
98%
|
|
K145 is a specific inhibitor of SphK2 (IC50: 4.30 μM), while no inhibition of SphK1 at concentrations up to 10 μM.
|
T9992 |
WAY-272077
|
1415662-57-5
|
98%
|
|
WAY-272077 is a sphingosine kinase inhibitor with anti-inflammatory, antitumor and hemostatic effects.
|
T2026 |
CYM5442
|
1094042-01-9
|
96.65%
|
|
CYM5442 is an S1P agonist, targeting to Sphingosine.
|
T10761 |
Ceranib-2
|
1402830-75-4
|
97.49%
|
|
Ceranib-2 is an inhibitor of ceramidase with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 decreases levels of sphingosine and S1P, induces cell apoptosis and exhib...
|
T7360 |
GSK2018682
|
1034688-30-6
|
97.78%
|
|
GSK2018682 is an agonist of sphingosine-1-phosphate receptor (s1p1) and (s1p5) agonist(pEC50s of 7.7 and 7.2,respectively).
|
T3258 |
Ponesimod
|
854107-55-4
|
98.01%
|
|
Ponesimod is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist that acts as a functional antagonist, with potential immunomodulating a...
|
T9199 |
GLPG2938
|
2130996-00-6
|
98.1%
|
|
GLPG2938 is a potent and selective antagonist of S1P2.
|
T3961 |
CYM-5541
|
945128-26-7
|
98.39%
|
|
CYM-5541 is a selective and allosteric S1P3 receptor agonist.
|
T22703 |
CYM-5520
|
1449747-00-5
|
98.72%
|
|
noncompetitive allosteric agonist of S1P2
|
T15629 |
JTE-013
|
383150-41-2
|
98.87%
|
|
JTE-013 is an effective and specific antagonist of S1P2. JTE-013 suppresses the specific binding of radiolabeled S1P to human and rat S1P2 (IC50s: 17 nM and 22 n...
|
T9014 |
SKI-178
|
1259484-97-3
|
99.2%
|
|
SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic ...
|