P2X Receptor

The ATP-gated P2X receptor cation channel family, or simply P2X receptor family, consists of cation-permeable ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). They belong to a larger family of receptors known as the ENaC/P2X superfamily. ENaC and P2X receptors have similar 3-D structures and are homologous. P2X receptors are present in a diverse array of organisms including humans, mouse, rat, rabbit, chicken, zebrafish, bullfrog, fluke, and amoeba.

Cat. No.	Product name	CAS No.	Purity
T19839	Oxatomide	60607-34-3	98%
T19839	Oxatomide is a potent and orally active dual H1 histamine receptor and P2X7 receptor antagonist with antihistamine and antiallergic activity.Oxatomide can be use...
T16399	Opiranserin	1441000-45-8	98%
T16399	Opiranserin is a development as an injectable agent for the treatment of postoperative pain. Opiranserin is a non-opioid and non-NSAID analgesic candidate and is...
T6526	GW791343 trihydrochloride	309712-55-8	98%
T6526	GW791343 HCl is aHCl salt form of GW791343, which is a non-competitive allosteric modulator of human P2X7 receptor inhibitor with pIC50 of 7.
TP2272	NF023 hexasodium	104869-31-0	98%
TP2272	NF023 hexasodium is a selective and competitive P2X1 receptor antagonist, with IC50 values of 0.21 μM, 28.9 μM, > 50 μM and > 100 μM for human P2X1, P2X3, P2X2, ...
T12568	PSB-12062	55476-47-6	98%
T12568	PSB-12062 is a potent and selective antagonist of P2X4(IC50 of 1.38 μM for human P2X4).
T14844	BX430	688309-70-8	98%
T14844	BX430 is used for chronic pain and cardiovascular disease and it is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with...
T61025	GSK-1482160	1001389-72-5	98%
T61025	GSK-1482160 is a CNS-penetrant negative allosteric modulator of P2X7 receptor with oral activity. The P2X7 receptor is involved in the production of pro-inflamma...
T5513	RO-3	1026582-88-6	98%
T5513	RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor
T4298	JNJ-47965567	1428327-31-4	98%
T4298	JNJ-47965567 is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel(with pKis of 7.9 and 8.7 for human and rat P2X...
T22518	5-BDBD	768404-03-1	98%
T22518	5-BDBD is a potent and selective P2X4 receptor antagonist. 5-BDBD inhibits rP2X4R-mediated currents with an IC50 of 0.75 μM. 5-BDBD completely blocked the basal ...
T5099	Gefapixant	1015787-98-0	98%
T5099	Gefapixant is a P2X3 receptor (P2X3R) antagonist with IC50 of ~30 nM at recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors.
T10207	A 438079	899507-36-9	98%
T10207	A 438079 is a potent, and selective antagonist of P2X7 receptor (pIC50: 6.9).
T14385	AZD9056 hydrochloride	345303-91-5	98%
T14385	AZD9056 hydrochloride is a P2X7 inhibitor，Which plays a significant role in pain-causing diseases and inflammation.
T14366	AZ10606120 dihydrochloride	607378-18-7	98%
T14366
T21659	AZ 11645373	227088-94-0	98%
T21659	AZ 11645373 is a highly selective and potent human P2X7 receptor antagonist that has no effect on mouse/rat P2X7 receptor.
T27683	JNJ-42253432	1428327-35-8	98%
T27683	JNJ-42253432 is an oral active P2X7 antagonist capable of penetrating the central nervous system with a pKi value of 9.1 for rat and 7.9 for human P2X7 channels....
T2087	AF-353	865305-30-2	98%
T2087	AF-353, an effective and orally bioavailable antagonist of the P2X3/P2X2/3 receptor, inhibits human and rat P2X3 (pIC50= 8.0).
T2694	KN-62	127191-97-3	98%
T2694	KN-62 is a potent and specific Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor with Ki of 0.9 μM.
T10466	BAY-1797	2055602-83-8	98%
T10466	BAY-1797 is an orally active and selective P2X4 antagonist (IC50: 211 nM against human P2X4) with anti-nociceptive and anti-inflammatory effects. BAY-1797 displa...
T9519	Eliapixant	1948229-21-7	98%
T9519	Eliapixant (BAY 1817080) is a potent and selective P2X3 receptor antagonist, with an IC50 of 8 nM. Eliapixant can be used for the research of refractory chronic ...