P2X Receptor

The ATP-gated P2X receptor cation channel family, or simply P2X receptor family, consists of cation-permeable ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). They belong to a larger family of receptors known as the ENaC/P2X superfamily. ENaC and P2X receptors have similar 3-D structures and are homologous. P2X receptors are present in a diverse array of organisms including humans, mouse, rat, rabbit, chicken, zebrafish, bullfrog, fluke, and amoeba.

Cat. No.	Product name	CAS No.	Purity
T78606	P2X3-IN-1	2823331-49-1	98%
T78606	P2X3-IN-1 (example 7) is a P2X3 receptor inhibitor suitable for research on neurogenic diseases [1].
T78639	Oxidized ATP trisodium salt	71997-40-5	98%
T78639	Oxidized ATP trisodium salt (oATP) is a broad-spectrum inhibitor of P2 receptors, irreversibly antagonizing P2X7R activation and inhibiting c-reactive protein (C...
T79115	P2X3 antagonist 38	2545974-71-6	98%
T79115	Compound 38, also known as Compound 4, is a potent, orally active P2X3 antagonist that demonstrates inhibitory activity with IC50 values of 0.132 µM, 0.165 µM, a...
T16399	Opiranserin	1441000-45-8	98%
T16399	Opiranserin is a development as an injectable agent for the treatment of postoperative pain. Opiranserin is a non-opioid and non-NSAID analgesic candidate and is...
T6526	GW791343 trihydrochloride	309712-55-8	98%
T6526	GW791343 trihydrochloride (GW791343 3HCl) is aHCl salt form of GW791343, which is a non-competitive allosteric modulator of human P2X7 receptor inhibitor with pI...
T71155	NP-1815-PX	1239578-80-3	98%
T71155	NP-1815-PX is a selective P2X4R antagonist with demonstrated anti-inflammatory effects and the capability to alleviate pain in chronic pain models. Additionally,...
TP2272	NF023 hexasodium	104869-31-0	98%
TP2272	NF023 hexasodium is a selective and competitive P2X1 receptor antagonist, with IC50 values of 0.21 μM, 28.9 μM, > 50 μM and > 100 μM for human P2X1, P2X3, P2X2, ...
T12568	PSB-12062	55476-47-6	99.97%
T12568	PSB-12062 (N-(p-Methylphenylsulfonyl)phenoxazine) is a potent and selective antagonist of P2X4(IC50 of 1.38 μM for human P2X4).
T14844	BX430	688309-70-8	99.95%
T14844	BX430 is used for chronic pain and cardiovascular disease and it is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with...
T61025	GSK-1482160	1001389-72-5	99.87%
T61025	GSK-1482160 is a CNS-penetrant negative allosteric modulator of P2X7 receptor with oral activity. The P2X7 receptor is involved in the production of pro-inflamma...
T5513	RO-3	1026582-88-6	99.87%
T5513	RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor
T3639	A-804598	1125758-85-1	99.8%
T3639	A-804598 is a competitive and selective P2X7 receptor antagonist (IC50: 10 nM, rat; 9 nM, mouse; 11 nM, human).
T4298	JNJ-47965567	1428327-31-4	99.76%
T4298	JNJ-47965567 (JNJ-479655) is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel(with pKis of 7.9 and 8.7 for huma...
T22518	5-BDBD	768404-03-1	99.74%
T22518	5-BDBD is a potent and selective P2X4 receptor antagonist. 5-BDBD inhibits rP2X4R-mediated currents with an IC50 of 0.75 μM. 5-BDBD completely blocked the basal ...
T5099	Gefapixant	1015787-98-0	99.72%
T5099	Gefapixant (AF219) is a P2X3 receptor (P2X3R) antagonist with IC50 of ~30 nM at recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors....
T10207	A 438079	899507-36-9	99.70%
T10207	A 438079 is a potent, and selective antagonist of P2X7 receptor (pIC50: 6.9).
T14385	AZD9056 hydrochloride	345303-91-5	99.52%
T14385	AZD9056 hydrochloride is a P2X7 inhibitor，Which plays a significant role in pain-causing diseases and inflammation.
T14366	AZ10606120 dihydrochloride	607378-18-7	99.49%
T14366	AZ10606120 dihydrochloride is a selectable, potent, high-affinity receptor antagonist with K D values of 1.4 and 19 nM at human and rat P2X 7 receptors, respecti...
T21659	AZ 11645373	227088-94-0	99.36%
T21659	AZ 11645373 (3-[1-[[(3'-NITRO[1,1'-BIPHENYL]-4-YL)OXY]METHYL]-3-(4-PYRIDINYL)PROPYL]-2,4-THIAZOLIDINEDIONE) is a highly selective and potent human P2X7 receptor ...
T27683	JNJ-42253432	1428327-35-8	99.08%
T27683	JNJ-42253432 is an oral active P2X7 antagonist capable of penetrating the central nervous system with a pKi value of 9.1 for rat and 7.9 for human P2X7 channels....