T19839 |
Oxatomide
|
60607-34-3
|
98%
|
|
Oxatomide is a potent and orally active dual H1 histamine receptor and P2X7 receptor antagonist with antihistamine and antiallergic activity.Oxatomide can be use...
|
T16399 |
Opiranserin
|
1441000-45-8
|
98%
|
|
Opiranserin is a development as an injectable agent for the treatment of postoperative pain. Opiranserin is a non-opioid and non-NSAID analgesic candidate and is...
|
T6526 |
GW791343 trihydrochloride
|
309712-55-8
|
98%
|
|
GW791343 HCl is aHCl salt form of GW791343, which is a non-competitive allosteric modulator of human P2X7 receptor inhibitor with pIC50 of 7.
|
TP2272 |
NF023 hexasodium
|
104869-31-0
|
98%
|
|
NF023 hexasodium is a selective and competitive P2X1 receptor antagonist, with IC50 values of 0.21 μM, 28.9 μM, > 50 μM and > 100 μM for human P2X1, P2X3, P2X2, ...
|
T12568 |
PSB-12062
|
55476-47-6
|
98%
|
|
PSB-12062 is a potent and selective antagonist of P2X4(IC50 of 1.38 μM for human P2X4).
|
T14844 |
BX430
|
688309-70-8
|
98%
|
|
BX430 is used for chronic pain and cardiovascular disease and it is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with...
|
T61025 |
GSK-1482160
|
1001389-72-5
|
98%
|
|
GSK-1482160 is a CNS-penetrant negative allosteric modulator of P2X7 receptor with oral activity. The P2X7 receptor is involved in the production of pro-inflamma...
|
T5513 |
RO-3
|
1026582-88-6
|
98%
|
|
RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor
|
T4298 |
JNJ-47965567
|
1428327-31-4
|
98%
|
|
JNJ-47965567 is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel(with pKis of 7.9 and 8.7 for human and rat P2X...
|
T22518 |
5-BDBD
|
768404-03-1
|
98%
|
|
5-BDBD is a potent and selective P2X4 receptor antagonist. 5-BDBD inhibits rP2X4R-mediated currents with an IC50 of 0.75 μM. 5-BDBD completely blocked the basal ...
|
T5099 |
Gefapixant
|
1015787-98-0
|
98%
|
|
Gefapixant is a P2X3 receptor (P2X3R) antagonist with IC50 of ~30 nM at recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors.
|
T10207 |
A 438079
|
899507-36-9
|
98%
|
|
A 438079 is a potent, and selective antagonist of P2X7 receptor (pIC50: 6.9).
|
T14385 |
AZD9056 hydrochloride
|
345303-91-5
|
98%
|
|
AZD9056 hydrochloride is a P2X7 inhibitor,Which plays a significant role in pain-causing diseases and inflammation.
|
T14366 |
AZ10606120 dihydrochloride
|
607378-18-7
|
98%
|
|
|
T21659 |
AZ 11645373
|
227088-94-0
|
98%
|
|
AZ 11645373 is a highly selective and potent human P2X7 receptor antagonist that has no effect on mouse/rat P2X7 receptor.
|
T27683 |
JNJ-42253432
|
1428327-35-8
|
98%
|
|
JNJ-42253432 is an oral active P2X7 antagonist capable of penetrating the central nervous system with a pKi value of 9.1 for rat and 7.9 for human P2X7 channels....
|
T2087 |
AF-353
|
865305-30-2
|
98%
|
|
AF-353, an effective and orally bioavailable antagonist of the P2X3/P2X2/3 receptor, inhibits human and rat P2X3 (pIC50= 8.0).
|
T2694 |
KN-62
|
127191-97-3
|
98%
|
|
KN-62 is a potent and specific Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor with Ki of 0.9 μM.
|
T10466 |
BAY-1797
|
2055602-83-8
|
98%
|
|
BAY-1797 is an orally active and selective P2X4 antagonist (IC50: 211 nM against human P2X4) with anti-nociceptive and anti-inflammatory effects. BAY-1797 displa...
|
T9519 |
Eliapixant
|
1948229-21-7
|
98%
|
|
Eliapixant (BAY 1817080) is a potent and selective P2X3 receptor antagonist, with an IC50 of 8 nM. Eliapixant can be used for the research of refractory chronic ...
|