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P2X Receptor

The ATP-gated P2X receptor cation channel family, or simply P2X receptor family, consists of cation-permeable ligand-gated ion channels that open in response to the binding of extracellular adenosine 5'-triphosphate (ATP). They belong to a larger family of receptors known as the ENaC/P2X superfamily. ENaC and P2X receptors have similar 3-D structures and are homologous. P2X receptors are present in a diverse array of organisms including humans, mouse, rat, rabbit, chicken, zebrafish, bullfrog, fluke, and amoeba.
Cat. No. Product name CAS No. Purity Chemical Structure
T6526 GW791343 trihydrochloride 309712-55-8 98%
GW791343 HCl is aHCl salt form of GW791343, which is a non-competitive allosteric modulator of human P2X7 receptor inhibitor with pIC50 of 7.
T16399 Opiranserin 1441000-45-8 98%
Opiranserin is a development as an injectable agent for the treatment of postoperative pain. Opiranserin is a non-opioid and non-NSAID analgesic candidate and is...
T9653 (E/Z)-Sivopixant 1640808-39-4 98%
(E/Z)-Sivopixantis a potent P2X3 receptor antagonist, IC50 = 4 nM. (E/Z)-Sivopixant can be used for respiratory diseases research.
T20731 Brilliant blue G-250 6104-58-1 98%
Brilliant Blue G is an antagonist of the P2X7 purinergic receptor.
T14920 CE-224535 724424-43-5 98%
CE-224535 is a selective antagonist of P2X7 receptor. CE-224535 can be used in disease-modifying antirheumatic studies.
T9786 Lu AF27139 2097117-06-9 98%
Lu AF27139 is an effective and selective antagonist of P2X7 receptor (IC50s of 12 and 2.4 nM for human and rat, Kis of 22, 54, and 13 nM for mouse, human, and ra...
T40045 Sivopixant 2414285-40-6 98%
Sivopixant (S-600918) is a potent and selective antagonist of P2X3 receptor (P2X3 IC 50 =4.2 nM; P2X2/3 IC 50 =1100 nM). Sivopixant shows strong analgesic effect...
T10207 A 438079 899507-36-9 98%
A 438079 is a potent, and selective antagonist of P2X7 receptor (pIC50: 6.9).
T9833 Opiranserin hydrochloride 1440796-75-7 98%
Opiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, ...
TP2226 BzATP triethylammonium salt 112898-15-4
BzATP triethylammonium salt is a P2X7 receptor agonist.
T8333 Aurintricarboxylic acid 4431-00-9
Aurintricarboxylic acid is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing ...
T37806 JNJ-55308942 2166558-11-6 100%
JNJ-55308942 is a selective and brain-penetrant antagonist of P2X7 functional with IC50s of 10 and 15 nM and Kis of 7.1 and 2.9 nM for hP2X7 and rP2X7, respectiv...
T7881 CTP disodium dihydrate 81012-87-5 100%
CTP disodium dihydrate is an agonist of P2X4 purinergic receptor
T2806 Lappaconitine 32854-75-4 92.57%
Lappaconitine, isolated from Aconitum sinomontanum Nakai, was characterized as an analgesic.
T7805 GW791343 dihydrochloride 1019779-04-4 95.57%
GW791343 dihydrochloride is a P2X7 allosteric modulator.
TQ0002 A-317491 475205-49-3 96.1%
A-317491 is a non-nucleotide P2X3 ( Ki: 22 nM) and P2X2/3 receptor (Ki: 9 nM) antagonist, which inhibits calcium flux mediated by the receptors.
T1131 Ivermectin 70288-86-7 97.74%
Ivermectin is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity.
T8946 Indophagolin 1207660-00-1 97.84%
Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and ...
T2087 AF-353 865305-30-2 97.95%
AF-353, an effective and orally bioavailable antagonist of the P2X3/P2X2/3 receptor, inhibits human and rat P2X3 (pIC50= 8.0).
T4S0536 Bullatine A 1354-84-3 98%
1. Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects, may be used for the treat...
GW791343 trihydrochloride
T6526
GW791343 HCl is aHCl salt form of GW791343, which is a non-competitive allosteric modulator of human P2X7 receptor inhibitor with pIC50 of 7.
Opiranserin
T16399
Opiranserin is a development as an injectable agent for the treatment of postoperative pain. Opiranserin is a non-opioid and non-NSAID analgesic candidate and is...
(E/Z)-Sivopixant
T9653
(E/Z)-Sivopixantis a potent P2X3 receptor antagonist, IC50 = 4 nM. (E/Z)-Sivopixant can be used for respiratory diseases research.
Brilliant blue G-250
T20731
Brilliant Blue G is an antagonist of the P2X7 purinergic receptor.
CE-224535
T14920
CE-224535 is a selective antagonist of P2X7 receptor. CE-224535 can be used in disease-modifying antirheumatic studies.
Lu AF27139
T9786
Lu AF27139 is an effective and selective antagonist of P2X7 receptor (IC50s of 12 and 2.4 nM for human and rat, Kis of 22, 54, and 13 nM for mouse, human, and ra...
Sivopixant
T40045
Sivopixant (S-600918) is a potent and selective antagonist of P2X3 receptor (P2X3 IC 50 =4.2 nM; P2X2/3 IC 50 =1100 nM). Sivopixant shows strong analgesic effect...
A 438079
T10207
A 438079 is a potent, and selective antagonist of P2X7 receptor (pIC50: 6.9).
Opiranserin hydrochloride
T9833
Opiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, ...
BzATP triethylammonium salt
TP2226
BzATP triethylammonium salt is a P2X7 receptor agonist.
Aurintricarboxylic acid
T8333
Aurintricarboxylic acid is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing ...
JNJ-55308942
T37806
JNJ-55308942 is a selective and brain-penetrant antagonist of P2X7 functional with IC50s of 10 and 15 nM and Kis of 7.1 and 2.9 nM for hP2X7 and rP2X7, respectiv...
CTP disodium dihydrate
T7881
CTP disodium dihydrate is an agonist of P2X4 purinergic receptor
Lappaconitine
T2806
Lappaconitine, isolated from Aconitum sinomontanum Nakai, was characterized as an analgesic.
GW791343 dihydrochloride
T7805
GW791343 dihydrochloride is a P2X7 allosteric modulator.
A-317491
TQ0002
A-317491 is a non-nucleotide P2X3 ( Ki: 22 nM) and P2X2/3 receptor (Ki: 9 nM) antagonist, which inhibits calcium flux mediated by the receptors.
Ivermectin
T1131
Ivermectin is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity.
Indophagolin
T8946
Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and ...
AF-353
T2087
AF-353, an effective and orally bioavailable antagonist of the P2X3/P2X2/3 receptor, inhibits human and rat P2X3 (pIC50= 8.0).
Bullatine A
T4S0536
1. Bullatine A, a diterpenoid alkaloid of the genus Aconitum, possesses anti-rheumatic, anti-inflammatory and anti-nociceptive effects, may be used for the treat...
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