vaccines

SM-102 is the only ionizable amino cationic lipid currently clinically approved for RNA therapeutics and can be used to synthesize lipid nanoparticles (LNPs). It shows potential in the development of LNPs for the delivery of mRNA-based vaccines.

Triton X-100 is a non-denaturing detergent that solubilizes lipid membranes. Triton X-100 is commonly used in laboratories and is applied to vaccines at different stages of the manufacturing process. Triton X-100 is listed as an excipient in certain vaccines including split virus influenza vaccines. Triton X-100 is a nonionic surfactant [1] [2].

Lipid M (pKa: 6.75) is a potential carrier for mRNA vaccines, offering enhanced immune responses and increased tolerability [1].

DOIC (a cationic lipid) is utilized in RNA vaccines [1].

3'Ome-m7GpppAmpG ammonium, a trinucleotide Cap analogue with a locked nucleic acid (LNA) component, demonstrates substantial translational efficiency. It emerges as a promising tool in molecular biology, applicable in mRNA vaccines and transfection processes including protein production, gene therapy, and anti-cancer immunization [1].

Heptadecan-9-yl 8-((6-(decyloxy)-6-oxohexyl)(2-hydroxyethyl)amino)octanoate is employed in lipid nanoparticle (LNP) delivery systems for mRNA vaccine delivery [1].

DSPE-PEG-SH (MW 2000), a pegylated phospholipid featuring a reactive thiol group for forming covalent thioether linkages with maleimide, is an amphiphilic polymer capable of self-assembling into lipid bilayers in aqueous solutions. It is utilized in encapsulating agents within drug delivery systems, including mRNA vaccines.

GL67 (N4-Spermine cholesteryl carbamate), a cationic lipid, facilitates the delivery of nucleic acid agents and vaccines, and is effective in gene transfection [1].

DMG-PEG 2000 (DMG-PEG2000) is a lipid excipient that has been used in combination with other lipids in the formation of lipid nanoparticles. Formulations containing DMG-PEG 2000 have been used in the development of lipid nanoparticles for the delivery of mRNA-based vaccines.

A12-Iso5-4DC19 is an ionizable cationic lipid that enhances mRNA delivery and is utilized in research concerning RNA vaccines.

Cholesterol-undecanoate-glucose conjugate is a cholesterol-linked compound used in the synthesis of nasal liposomal vaccines and can also be utilized in research focused on drug delivery.

3D-Monophosphoryl Lipid A-5 (3D-MPLA-5) is a TLR agonist that can serve as an adjuvant in vaccines to enhance their immunogenicity.

GL67 (N4-Spermine cholesteryl carbamate) (pentahydrochloride) is a cationic lipid. It is utilized for the delivery of nucleic acid active molecules, vaccines, and for gene transfection.

DSPE-PEG-NHS, MW 2000, is a PEGylated phospholipid derivative utilized in the preparation of liposomes for the delivery of DNA or mRNA vaccines.

VC1052 is a component of HY-142998 Vaxfectin. Vaxfectin is a cationic lipid adjuvant used for vaccines based on plasmid DNA and proteins.

DSPE-PEG-azide (MW 5000) is a click chemistry reactive phospholipid polyPEG capable of forming lipid bilayers or micelles in aqueous solutions. This polymer is suitable for creating liposomes or nanoparticles intended for the delivery of nutrients or therapeutic agents, such as mRNA or DNA vaccines. It is of reagent grade and intended for research use only.

DSPE-PEG-Ald, MW 3400, is a self-assembling poly PEG that spontaneously forms lipid bilayers in water. This polymer can be used to prepare nanoparticles or liposomes as targeted drug carriers, such as mRNA vaccines. The aldehyde group reacts with aminooxy groups to form stable oxime bonds, or with amines at pH < 7 to form reversible imine bonds. Reagent grade, for research use only.

DSPE-PEG-Ald, MW 5000, is a phospholipid PEG polymer with a hydrophilic head oriented towards water (micelle), allowing it to spontaneously self-assemble in aqueous environments. It is utilized in forming liposomes for drug nanocarriers, applicable in delivering nutrients and therapeutic agents, such as lipid nanoparticles in mRNA or DNA vaccines. The aldehyde group can react with aminooxy groups to form stable oxime linkages or with amines at pH < 7 to create reversible imine bonds. This compound is available as reagent grade, for research use only.

DSPE-PEG-OH, MW 5000, is a linear phospholipid PEG polymer. The lipid tail permits the encapsulation of hydrophobic therapeutic agents, while the PEG chain maintains its hydrophilicity. This polymer can be utilized in drug nanocarriers, such as liposomal anticancer drugs or mRNA DNA vaccines. It is reagent grade and intended solely for research purposes.

DSPE-PEG-SH (MW 1000) is an amphiphilic PEG polymer that forms a lipid bilayer in aqueous solutions. This polymer can encapsulate active molecules and is applicable in drug delivery systems, such as mRNA vaccines.

DSPE-PEG-SPDP, MW 1000, is a thiol-reactive PEG lipid. This amphiphilic polymer spontaneously forms lipid bilayers in water. It is employed for encapsulating nutrients or therapeutics for targeted drug delivery, such as mRNA or DNA vaccines, or liposomal doxorubicin for anti-tumor applications. Reagent grade, for research use only.

DSPE-PEG-Vinylsulfone, MW 3400 is a thiol-reactive PEG lipid. This polymer spontaneously self-assembles in aqueous solutions to form lipid bilayers and can be used to prepare nanoparticles or liposomes for drug delivery applications, such as mRNA vaccines or DNA vaccines. Reagent grade, for research use only.

DSPE-PEG-Vinylsulfone, MW 5000, is a vinyl sulfone PEG lipid that can undergo bio-conjugation with cysteine or other thiol molecules through a thiol-ene reaction. This polymer serves as a self-assembling agent, forming lipid bilayers in water and is utilized as a drug carrier for delivering therapeutic agents like mRNA or DNA vaccines. Reagent grade, intended for research use only.

DSPE-PEG-Rhodamine, MW 2000, is a PEG lipid conjugated with a fluorescent dye. This amphiphilic polymer can form lipid bilayers in water, suitable for encapsulating therapeutic agents such as liposomal anticancer drugs or mRNA vaccines. Rhodamine has a maximum absorption wavelength of 570 nm and a maximum emission wavelength of 595 nm. The red Rhodamine dye can be easily tracked using imaging techniques.