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Results for "

thymidylate synthase

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    53
    TargetMol | Inhibitors_Agonists
  • Peptide Products
    1
    TargetMol | Peptide_Products
  • Natural Products
    3
    TargetMol | Natural_Products
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    2
    TargetMol | Isotope_Products
  • Antibody Products
    1
    TargetMol | Antibody_Products
5-Fluorouracil
NSC 19893, Fluorouracil, 5-FU, 5-Fluoracil
T098451-21-8
5-Fluorouracil (5-FU) is a uracil analog and inhibitor of DNA synthesis, exhibiting antitumor activity by affecting pyrimidine synthesis through thymidylate synthase inhibition; it induces apoptosis and autophagy.
  • $30
In Stock
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Floxuridine
NSC 27640, FUDR, Deoxyfluorouridine, 5-Fluorouracil 2'-deoxyriboside
T096450-91-9
Floxuridine (FUDR) is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.
  • $30
In Stock
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Trimethoprim
NSC-106568, NIH 204, BW 56-72
T1153738-70-5
Trimethoprim (NSC-106568) is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochrome P450 2C8 Inhibitor, and Organic Cation Transporter 2 Inhibitor.
  • $45
In Stock
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Trifluridine
Viroptic, Trifluridina, Trifluorothymidine, NSC 75520, NSC 529182, 5-Trifluorothymidine
T142870-00-8
Trifluridine (NSC-75520) is a fluorinated thymidine analog with potential antineoplastic activity. Trifluridine is incorporated into DNA and inhibits thymidylate synthase, resulting in inhibition of DNA synthesis, inhibition of protein synthesis, and apoptosis. This agent also exhibits antiviral activity.
  • $30
In Stock
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2'-Deoxyuridine
Uracil deoxyriboside, 2'-dU, 2-deoxyuridine
T1721951-78-0
2'-Deoxyuridine (2-deoxyuridine). An antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemias due to vitamin B12 and folate deficiencies.
  • $30
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5-Fluoroorotic acid
T19833703-95-7
5-Fluoroorotic acid is an inhibitor of thymidylate synthase. 5-Fluoroorotic is a selective agent in yeast molecular genetics.5-Fluoroorotic possesses a well-expressed anticandidal effect close to that of 5-fluorocytosine, as well as moderate antidermatophytal effects.
  • $44
In Stock
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Raltitrexed
ZD1694, Tomudex, ICI-D1694, D1694
T6632112887-68-0
Raltitrexed (D1694)(IC50 of 9 nM), a thymidylate synthase inhibitor, is used for the inhibition of L1210 cell growth.
  • $31
In Stock
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Galocitabine
RO-09-1390, RO-091390, RO091390, RO 091390, Neofrutulon
T27399124012-42-6In house
Galocitabine (Neofrutulon), a thymidylate synthase inhibitor, is used potentially for the treatment of cancer.
  • $83
In Stock
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TargetMol | Inhibitor Sale
Folinic acid calcium
Wellcovorin, Leucovorin Calcium, Folinic acid calcium salt, Calcium folinate
T01481492-18-8
Folinic acid calcium (Leucovorin Calcium) is the active metabolite of folic acid. Leucovorin is used principally as an antidote to folic acid antagonists.
  • $42
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Pemetrexed
Pemetrexed acid, LY231514 Disodium Hydrate, LY231514
T0189137281-23-3
Pemetrexed (LY-231514 Disodium Hydrate), a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).
  • $33
In Stock
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Pemetrexed disodium
LY231514 disodium
T0189L150399-23-8
Pemetrexed disodium (LY-231514) is a parenterally administered folate antagonist and antineoplastic agent, used in the treatment of non-small cell lung cancer and malignant mesothelioma. Pemetrexed disodium therapy has been associated with moderate rates of serum enzyme elevations during therapy, but has not been convincingly linked to instances of acute, clinically apparent liver injury.
  • $37
In Stock
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rac-belinostat
PXD101, PX-105684, NSC726630
T1852414864-00-9
Rac-Belinostat (PX-105684) is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting tumor cell proliferation, inducing apoptosis, promoting cellular differentiation, and inhibiting angiogenesis. This agent may sensitize drug-resistant tumor cells to other antineoplastic agents, possibly through a mechanism involving the down-regulation of thymidylate synthase.
  • $37
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Trifluridine/tipiracil hydrochloride mixture
Trifluridine-tipiracil hydrochloride mixture, TAS-102, TAS102, TAS 102
T3658733030-01-8
Trifluridine tipiracil hydrochloride mixture (TAS-102) is a novel oral combination drug containing trifluridine (TFT) and tipiracil hydrochloride (TTP) in a 2:1 molar ratio.
  • $33
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Pemetrexed disodium hemipenta hydrate
Pemetrexed Disodium Hydrate, LY-231514 Disodium Hydrate, Pemetrexed sodium hydrate
T6226357166-30-4
Pemetrexed disodium hemipenta hydrate (LY-231514 Disodium Hydrate) is a new-type antifolate and antimetabolite for TS, DHFR, and GARFT. The Ki of Pemetrexed Disodium Hydrate for TS, DHFR and GARFT is 1.3 nM, 7.2 nM and 65 nM, respectively.
  • $33
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(R)-Plevitrexed
(R)-ZD 9331, (R)-BGC9331
T12635153537-74-7
(R)-Plevitrexed is a less active enantiomer of Plevitrexed. Plevitrexed is an orally active and potent inhibitor of thymidylate synthase (TS).
  • $2,720
3-6 months
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Plevitrexed
ZD 9331, BGC9331
T12635L153537-73-6
Plevitrexed is taken up via the α-folate receptor as well as the reduced folate carrier. Plevitrexed is an orally active and effective thymidylate synthase (TS) inhibitor (Ki: 0.44 nM). Plevitrexed is used for gastric cancer in clinical.
  • $2,720
3-6 months
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(Rac)-Plevitrexed
(Rac)-ZD 9331, (Rac)-BGC9331
T12674153538-08-0
(Rac)-Plevitrexed is a racemate of Plevitrexed. Plevitrexed is an orally active and potent inhibitor of thymidylate synthase (TS).
  • $3,320
3-6 months
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Hydroxyethyl disulfide
T2017691892-29-1
Hydroxyethyl disulfide can counteract the inhibitory effects of showdomycin on methotrexate-resistant thymidylate synthase and is protected from deactivation by its substrate, deoxyuridine monophosphate, thus preserving the antibiotic's activity.
  • Inquiry Price
10-14 weeks
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Methylbenzoprim
NSC-382035, TYMS inhibitor 19-S, NSC 382035, NSC382035, TYMS In 19-S, TYMS In 19S, TYMS-In-19-S, TYMS-In-19S
T202109118344-71-1
Methylbenzoprim is an innovative multifunctional thymidylate synthase (TYMS) inhibitor. It exhibits greater antitumor activity compared to current fluoropyrimidines and antifolates, without inducing TYMS overexpression. In pancreatic xenograft tumor models and hTS Ink4a Arf null genetically engineered mouse models, Methylbenzoprim effectively prolongs survival.
  • Inquiry Price
10-14 weeks
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TS-IN-5
T204796
TS-IN-5 (Compound 15) is an inhibitor of thymidylate synthase (TS). It induces apoptosis by modulating the proteins Bax, BCL-2, PI3K, and STAT1. TS-IN-5 exhibits antitumor activity against liver cancer, breast cancer, and colon cancer.
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Insecticidal agent 19
T205222
Insecticidal agent 19 (Compound 7b) exhibits antimalarial activity by inhibiting dihydrofolate reductase-thymidylate synthase (DHFR-TS) and pteridine reductase 1 (PTR1) through the folate metabolic pathway. This compound also inhibits the promastigote and amastigote forms of Leishmania major, with IC50 values of 1.43 μM and 3.78 μM, respectively.
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TS-IN-6
T205447
TS-IN-6 (Compound 10) is a thymidylate synthase (TS) inhibitor with an IC50 value of 0.54 μM, showing significant antiproliferative activity. It can induce G1 phase cell cycle arrest and apoptosis (with notable increases in early and late apoptosis rates) and is useful for research in cancers such as colon, breast, and liver cancer.
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Amsilarotene
TAC-101, TAC101, TAC 101
T21314125973-56-0
Amsilarotene (TAC101) inhibits the phosphorylation of retinoblastoma gene product (RB) and increases the presence of 2 cyclin-dependent kinases (CDK) inhibitors resulting in cell cycle arrest. This agent also causes a cytotoxic decline in the thymidylate synthase and cyclin A expression.
  • $36
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Folitixorin
ANX-510 free acid, ANX510 free acid, 5,10-Methylenetetrafolate
T213153432-99-3
Folitixorin (ANX-510) is an active folate derivative and coenzyme associated with thymidine synthesis, with potential antitumour activity.
  • $1,368
In Stock
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