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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T74631 | RNA polymerase II-IN-2 | ||
RNA polymerase II-IN-2 (compound 20iii), a potent inhibitor of RNA polymerase II (Pol II) with a K i value of 9.5 nM, demonstrates cytotoxicity against cancer cells, exhibiting toxicity levels 2 and 5 times higher than α... | |||
T74630 | RNA polymerase II-IN-1 | DNA/RNA Synthesis | |
RNA polymerase II-IN-1 (compound 19iv), an amatoxin, selectively inhibits RNA polymerase II (Pol II) with an IC50 of 36.66 nM. It exhibits heightened cytotoxicity towards cancer cells and reduced toxicity in normal cells... | |||
T8972 | FIT-039 | Others , DNA/RNA Synthesis , CDK , HSV | |
FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1). FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV. FIT-039 is a pr... | |||
T4356 | POL1-IN-1 | Compound 3A | DNA/RNA Synthesis |
POL1-IN-1 (Compound 3A) can effectively inhibit the transcription of RNA polymerase I in the A375 malignant melanoma cell line but has no effect on polymerase II. | |||
T70388 | (S)-Enitociclib | VIP152 | CDK |
(S)-Enitociclib (VIP152) is a selective CDK9 inhibitor that induces complete regression of MYC+ lymphomas by inhibiting RNA polymerase II-mediated transcription of anti-apoptotic and pro-survival proteins. | |||
T79404 | A09-003 | Apoptosis , BCL , CDK | |
A09-003 is a novel cell cycle protein-dependent kinase-9 CDK-9 inhibitor.A09-003 inhibits the proliferation of a variety of leukemia cell lines and inhibits the increase of leukemia sequence-1 protein in myeloid cells.A0... | |||
T77520 | AOH1996 | Apoptosis , DNA/RNA Synthesis | |
AOH1996 is an orally active ligand for the replicasome component PCNA (proliferating cell nuclear antigen), targeting the transcription-replication conflict (TRC).AOH1996 interferes with the interaction of PCNA with its ... | |||
T13540 | Alpha-Amanitin | α-Amanitin,α-Amatoxin | Others |
alpha-Amanitin is the principal toxin of poisonous mushrooms, exerting its toxic function by inhibiting RNA-polymerase II. | |||
T40359 | Thio-ITP | 6-Thio-ITP,Thio-ITP,6-Mercaptopurine-riboside-5'-triphosphate,6-Thioinosine 5′-triphosphate | |
Thio-ITP, also known as 6-Thioinosine 5'-triphosphate, is a competitive inhibitor of RNA polymerase activity. It exhibits a strong apparent affinity towards the polymerases, with Ki values of 40.9 μM for RNA polymerase I... | |||
T39649 | ε-Amanitin | ||
ε-Amanitin is a cyclic peptide obtained from various mushroom species. It exhibits a strong affinity for RNA polymerase II and effectively inhibits its activity. | |||
T29453 | 5-Formylcytosine | ||
5-formylcytosine (5FC) is a rare base found in mammalian DNA. It participates in active DNA demethylation, changes DNA double helix structure, and reduces the transcription rate and substrate specificity of RNA polymeras... | |||
T18249 | Mal-C6-α-Amanitin | Others | |
Mal-C6-α-Amanitin, an ADC (antibody-drug conjugate) linker drug, incorporates the powerful antitumor agent α-Amanitin, an inhibitor of RNA polymerase II, through the Mal-C6 linker, showcasing potent antitumor activity. | |||
T39562 | γ-Amanitin | ||
γ-Amanitin, an ADC (antibody-drug conjugate) cytotoxin isolated from mushrooms, inhibits RNA polymerase II, disrupting mRNA synthesis. It exhibits effects akin to those of α-Amanitin and β-Amanitin. | |||
T36685 | TAF 10 Peptide | ||
TAF10 is one of many protein factors or coactivators associated with RNA polymerase II activity. One vial of this peptide may be used as a methyltransferase acceptor peptide for more than 200 reactions at 15 μM. | |||
T10436L | AZD4573 HCl (2057509-72-3 free base) | AZD4573 hydrochloride,AZD4573,AZD4573 HCl,AZD-4573,AZD 4573 | |
AZD-4573 is a selective and short-acting inhibitor of the serine/threonine cyclin-dependent kinase 9, the catalytic subunit of the RNA polymerase II elongation factor positive transcription elongation factor b. It also h... | |||
TP1683 | [pSer2, pSer5, pSer7]-CTD | ||
[pSer2, pSer5, pSer7]-CTD is a substrate for CDK7(cyclin-dependent protein kinase), a phosphorylated polypeptide at ser2, ser5, and ser7 of RNA polymerase II carboxyl terminus (CTD). | |||
TP1641 | [pSer2, pSer5, pSer7]-CTD TFA | ||
[pSer2, pSer5, pSer7]-CTD (TFA) is a substrate for CDK7(cyclin-dependent protein kinase), a phosphorylated polypeptide at ser2, ser5, and ser7 of RNA polymerase II carboxyl terminus (CTD). | |||
T13474 | β-Amanitin | Others | |
β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom, and inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. | |||
T83836 | 3'-O-Methylguanosine-5'-O-triphosphate sodium | 3'-O-methyl GTP | |
3'-O-Methylguanosine-5'-O-triphosphate (3'-O-methyl GTP), a methylated derivative of GTP, serves as a chain termination reagent in synthesizing early RNA polymerase II elongation intermediates. | |||
T74659 | Dideoxy-amanitin | ||
Dideoxy-amanitin (compound 2), a derivative of α-Amanitin, functions as a potent, selective allosteric inhibitor of RNA polymerase II, demonstrating an inhibition concentration (IC50) of 74.2 nM [1]. |