plasminogen activator inhibitor-1

Expression system: E. coli
Length: 1-260, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-280, Partial
Activity: Not Tested

Expression system: P. pastoris (Yeast)
Length: 1-280, Partial
Activity: Not Tested

Expression system: P. pastoris (Yeast)
Length: 23-402, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 23-402, Full Length of Mature Protein
Activity: Not Tested

Plasminogen activator inhibitor-1 (serpin E1) is a serine protease inhibitor which belongs to the serpin family. Serpin E1 acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3 TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.

Expression system: HEK293 Cells
Length: 25-413, Full Length of Mature Protein
Activity: Not Tested

PAI-1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 69.6 kDa and the accession number is A6J047.

Expression system: HEK293 Cells
Length: 1-402, Full Length
Activity: Enzyme Activity

Expression system: Baculovirus Insect Cells
Length: 1-415, Full Length
Activity: ELISA

PAI-1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.2 kDa and the accession number is A6J047.

Serine threonine-protein kinase 16, also known as myristoylated and palmitoylated serine threonine-protein kinase, Protein kinase PKL12, TGF-beta-stimulated factor 1, TSF-1, MPSK1 and STK16, is a membrane protein that is ubiquitously expressed at very low levels. STK16 MPSK1 belongs to the protein kinase superfamily and Ser Thr protein kinase family. It contains one protein kinase domain. Transforming growth factor-beta (TGF-beta) shows a variety of biological activities in various organs or cells. Some factors such as Smads (Sma and Mad proteins) and TGF-beta activating kinase 1 have been characterized as signalling molecules downstream of TGF-beta. Several TGF-beta response elements have been identified such as cAMP response element, Smad binding element, and recognition sites for activating protein-1 and stimulating protein-1 in various gene promoters. STK16 MPSK1 is a unique factor with two biological functions, transcriptional regulation and protein phosphorylation, that may be involved in TGF-beta signals. STK16 MPSK1 is a protein kinase that acts on both serine and threonine residues. STK16 MPSK1 possessed DNA-binding ability and activated the TGF-beta responsive CNP promoter or vascular endothelial growth factor gene promoter which possesses a sequence element analogous to the TGF-beta responsive GC-rich element of the CNP promoter. STK16 MPSK1 did not directly activate a Smads-dependent promoter from plasminogen activator inhibitor 1 gene, but it showed enhancement in co-operation with Smad3 and Smad4. STK16 MPSK1 mRNA as well as its protein level were stimulated by TGF-beta treatment.