plasminogen activator inhibitor-1

Expression system: P. pastoris (Yeast)
Length: 1-280, Partial
Activity: Not Tested

Expression system: E. coli
Length: 1-280, Partial
Activity: Not Tested

Expression system: E. coli
Length: 1-260, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 23-402, Full Length of Mature Protein
Activity: Not Tested

Expression system: P. pastoris (Yeast)
Length: 23-402, Full Length of Mature Protein
Activity: Not Tested

PAI-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.2 kDa and the accession number is A0A024QYT5.

PAI-1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 69.6 kDa and the accession number is A6J047.

PAI-1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.2 kDa and the accession number is A6J047.

Plasminogen activator inhibitor-1 (serpin E1) is a serine protease inhibitor which belongs to the serpin family. Serpin E1 acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3 TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis.

Serine threonine-protein kinase 16, also known as myristoylated and palmitoylated serine threonine-protein kinase, Protein kinase PKL12, TGF-beta-stimulated factor 1, TSF-1, MPSK1 and STK16, is a membrane protein that is ubiquitously expressed at very low levels. STK16 MPSK1 belongs to the protein kinase superfamily and Ser Thr protein kinase family. It contains one protein kinase domain. Transforming growth factor-beta (TGF-beta) shows a variety of biological activities in various organs or cells. Some factors such as Smads (Sma and Mad proteins) and TGF-beta activating kinase 1 have been characterized as signalling molecules downstream of TGF-beta. Several TGF-beta response elements have been identified such as cAMP response element, Smad binding element, and recognition sites for activating protein-1 and stimulating protein-1 in various gene promoters. STK16 MPSK1 is a unique factor with two biological functions, transcriptional regulation and protein phosphorylation, that may be involved in TGF-beta signals. STK16 MPSK1 is a protein kinase that acts on both serine and threonine residues. STK16 MPSK1 possessed DNA-binding ability and activated the TGF-beta responsive CNP promoter or vascular endothelial growth factor gene promoter which possesses a sequence element analogous to the TGF-beta responsive GC-rich element of the CNP promoter. STK16 MPSK1 did not directly activate a Smads-dependent promoter from plasminogen activator inhibitor 1 gene, but it showed enhancement in co-operation with Smad3 and Smad4. STK16 MPSK1 mRNA as well as its protein level were stimulated by TGF-beta treatment.

Alpha-1-antitrypsin 1-5(SERPIN A1) is a secreted protein and belongs to the serpin family. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. Mouse SERPIN A1 is a serine protease inhibitor whose targets include elastase,plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema orliver disease. Several transcript variants encoding the same protein have been found for this gene.

Expression system: Baculovirus Insect Cells
Length: 1-415, Full Length
Activity: ELISA