pc-2

Phytochelatin 2, a short plant peptide, serves as an essential metal-binding compound. Phytochelatins are a diverse group of plant compounds that play a crucial role in chelating metals, safeguarding against metal toxicity, and maintaining metal homeostasis.

Phytochelatin 2 (PC2) TFA, a heavy metal-binding peptide, facilitates metal chelation, mitigates metal toxicity, and promotes metal homeostasis within internal environments [1].

Pc 14:0-22:6-D7 (4Z,7Z,10Z,13Z,16Z,19Z) (Pc2 Aa C36:6 Is) (Standard) Is) (Standard) is a reference standard of Pc 14:0-22:6-[D7] (4Z,7Z,10Z,13Z,16Z,19Z) (Pc2 Aa C36:6 Is) intended for quantitative analysis, quality control, and related biochemical research applications.

PC 14:0-22:6(4Z,7Z,10Z,13Z,16Z,19Z) (PC2 aa C36:6) (Standard) is a reference standard of PC 14:0-22:6(4Z,7Z,10Z,13Z,16Z,19Z) (PC2 aa C36:6) intended for quantitative analysis, quality control, and related biochemical research applications.

OPC-28326 is a specific an α2-adrenergic receptor antagonist and acts as a peripheral vasodilator. OPC-28326 inhibits α2A-, α2B- and α2C-adrenoceptors with Ki of 2040, 285, and 55 nM, respectively.

YPC-22026 has potential anticancer activity, inducing tumor regression in a mouse xenograft model while inhibiting ZNF143-regulated genes.

KPC-2-IN-3 (Compound 3b) is a KPC-2 inhibitor with an IC50 of 0.533 μM and a Ki of 0.194 μM. It works synergistically with Meropenem to exhibit antibacterial activity against carbapenem-resistant K. pneumoniae K47-25, reducing bacterial count and demonstrating a post-antibiotic effect. Additionally, KPC-2-IN-3 significantly decreases lung bacterial load in a mouse pneumonia model.

JPC-211 is an agonist of dopamine-receptor.

KPC-2-IN-2 (Compound 6c) is a potent Klebsiella pneumoniae carbapenemase (KPC-2) inhibitor with a Ki of 0.038 μM and can enhance the activity of cefotaxime in E. coli expressing KPC-2 [1].

KPC-2-IN-1, a boronic acid derivative, serves as an effective KPC-2 inhibitor with a K i of 0.032 μM, augmenting cefotaxime's efficacy against KPC-2 expressing E. coli. It demonstrates good tolerance in human HEK-293 cells, rendering it valuable for researching E. coli's resistance to β-lactam antibiotics [1] [2].

Anti-GPC-2 Antibody (CT3) is a mouse-derived IgG1, κ chimeric antibody specifically targeting human GPC-2. The recommended isotype control for this antibody is Mouse IgG1 kappa, Isotype Control.

Durlobactam sodium salt (ETX2514) is a beta-lactamase inhibitor with IC50 values of 4 nM, 14 nM and 190 nM against class A KPC-2, class C AmpC and class D OXA-24.

Cilostazol (OPC 21) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of cilostazol is as a Phosphodiesterase 3 Inhibitor.

Avibactam sodium (NXL-104) is a non-β-lactam β-lactamase inhibitor that inhibits TEM-1, P99, and KPC-2 β-lactamases (IC50=8/80/38 nM) covalently and reversibly. Avibactam sodium has antimicrobial activity and can be used to treat urinary tract infections.

Benproperine phosphate (Pirexyl phosphate) is a cough suppressant.

PC 20:0-20:2 (PC6 aa C40:2) (Standard) is a reference standard of PC 20:0-20:2 (PC6 aa C40:2) intended for quantitative analysis, quality control, and related biochemical research applications.

Crolibulin (EPC2407) is an inhibitor of small molecule tubulin polymerization.

VPC 23019 is a competitive antagonist at the S1P1 and S1P3 receptors (pKi= 7.86 and 5.93, respectively). It is also an agonist at the S1P4 and S1P5 receptors (pEC50= 6.58 and 7.07, respectively).

Thalidomide-piperidine-C-Pip-C2-Pip-C2-OH (Compound C6) is a conjugate linking a ligand and an E3 ligase, which is utilized in the synthesis of PROTAC PARP1 degrader-30.

NPC26 is a small molecule that disrupts mitochondrial function and exhibits antitumor activity. It shows significant antiproliferative and cytotoxic effects on CRC cell lines (HCT-116, DLD-1, and HT-29). NPC26 induces mitochondrial permeability transition pore (mPTP) opening, generates reactive oxygen species (ROS), and triggers cell death. Additionally, NPC26 kills CRC cells by activating the AMP-activated protein kinase (AMPK) signaling pathway.

Beclanorsen sodium is an antisense oligonucleotide that targets Bcl-2 mRNA.

Beclanorsen is an antisense oligonucleotide that specifically targets Bcl-2 mRNA.

TPC2-A1-N is a novel lipophilic, membrane-permeable subtype-selective TPC2 small molecule agonist that activates endogenous TPC2 to moderately increase lysosomal pH in untransfected cells in a time-dependent manner, and can be used to assay the differential function of TPC2 channels in intact cells.

TPC2-A1-P is a membrane-permeable two-pore channel 2 (TPC2) agonist that differentially activates two-pore channel 2 (TPC2) and mimics the activation of TPC2 with NAADP and PIP(2). TPC2-A1-P can be used to study neurodegenerative lysosomal storage diseases.