p388

Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM). Etoposide has antitumor activity and induces apoptosis and autophagy.

Erythromycin (E-Mycin) is a Macrolide and Macrolide Antimicrobial. The physiologic effect of erythromycin is by means of Decreased Sebaceous Gland Activity.

N-acetyltyramine is a metabolite of the biogenic amine tyramine . It enhances cytotoxicity of doxorubicin in resistant P388 murine leukemia cells with an IC50 value of 0.13 μg ml compared with an IC50 value of 0.48 μg ml for doxorubicin alone.

Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts growth inhibition and cytotoxic activity against a variety of human Y cell lines.

Nordihydroguaiaretic acid (NDGA) is a natural product, extracted from Pole Fork Kelaroa, and is a lipoxygenase (5-LOX) inhibitor (IC50=8 μM). Nordihydroguaiaretic acid possesses antioxidant and free radical scavenging properties.

BE-10988 is a DNA topoisomerase (DNAtopoisomerase) inhibitor. It suppresses the growth of P388 murine leukemia cell lines that are resistant to Doxorubicin and Vinblastine by promoting the formation of DNA topoisomerase complexes.

19,20-Epoxycytochalasin D is a fungal metabolite that has been found in the endophytic fungus Nemania sp. UM10M. It is active against the chloroquine-sensitive and -resistant strains of P. falciparum (MIC = 0.4 ng/ml for both) without inducing cytotoxicity in Vero cells. It is cytotoxic to BT-549, LLC-PK11, and P388 cells (IC50s = 7.84, 8.4, and 0.16 µM, respectively) but not SK-MEL, KB, or SKOV3 cells up to a concentration of 10 µM.

Penicillide is a fungal metabolite originally isolated from Penicillium that has diverse biological activities. It is an inhibitor of calpain 2/m-calpain (IC50 = 7.1 μM) and acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 22.9 μM). It is also an antagonist of oxytocin receptors (IC50 = 67 μM). Penicillide inhibits RNA synthesis in P388 murine leukemia cells.

Amoorastatin is a natural product that has been studied in cancer research. Its derivative was found to significantly inhibit growth of the murine P388 lymphocytic leukemia cell lines.

11-epi-Chaetomugilin I, a metabolite identified in Chaetomium globosum, demonstrates notable cytotoxic activity against several cell lines, including the murine P388 and L1210 leukemia cell lines, the human HL-60 leukemia cell line, and the human KB epidermoid carcinoma cell line [1].

T988C, a heptacyclic epidithiodioxopiperazine (ETP) natural product, exhibits potent cytotoxicity against cultured P388 leukemia cells [1].

Kulinone has cytotoxic effects, with IC50 values of 5.6-21.2 ug/mL, it inhibited (ED(50) 2.5-6.2 microg/mL) the P388 cancer cell line.

Cremimycin exhibits activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), with a minimum inhibitory concentration (MIC) of 0.2-0.39 μg/mL. Additionally, Cremimycin demonstrates cytotoxic effects on mouse tumor cell lines P388, L1210, IMC, S180, B16, and SS3 in vitro.

Cremeomycin exhibits activity against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), with a minimum inhibitory concentration (MIC) of 0.2-0.39 μg/mL. It also demonstrates cytotoxic effects in vitro against mouse tumor cell lines P388, L1210, IMC, S180, B16, and SS3.

Cochleamycin A exhibits strong inhibitory activity against tumor cells, with IC50 values (μg/mL) of 1.6, 14.0, 6.2, 16.5, and 19.1 for P388, HL60, K562, COL0205, and HT29 cells, respectively. Additionally, Cochleamycin A possesses activity against Gram-positive bacteria.

Lactoquinomycin A is a quinone antibiotic displaying activity against Gram-positive bacteria and some Gram-negative bacteria, though its efficacy is weaker against the latter and it is ineffective against fungi. It inhibits various cell lines, including lymphoma L5178Y progenitor cells, doxorubicin-resistant cells, bleomycin-resistant cells, human leukemia K562 cells, murine leukemia L-1210 cells, and murine leukemia P388 cells, with ID50 values (μg/mL) of 0.02, 0.006, 0.008, 0.033, 0.013, and 0.03, respectively.

Saquayamycin A exhibits antibacterial properties, although its effect on Gram-negative bacteria is relatively weak. It also demonstrates inhibitory activity against leukemia P388 cells and adriamycin-resistant P388 cells.

Miyakamide B2 is an antibiotic with insecticidal properties. It suppresses the growth of brine shrimp and shows weak activity against Xanthomonas species. The IC50 for inhibition of P388 cells by Miyakamide B2 is 7.6 μg/mL.

Glidobactin F is an antitumor antibiotic effective against pathogenic fungi and yeasts. It has been shown to increase the survival time of mice inoculated with leukemia P388 cells.

Eponemycin is an antibiotic with antitumor properties. It exhibits cytotoxicity against cancer cell lines B16-F10, L1210, P388, and HCT-116, with IC50 values of 0.0017, 0.01, 0.031, and 0.0097 µg/mL, respectively. In B16-F10 and mitomycin C, Eponemycin inhibits DNA synthesis, with IC50 values of 0.1 µg/mL and 0.41 µg/mL, respectively.

Elloramycin exhibits mild activity against Gram-positive bacteria, streptomycetes, and L-1210 leukemia cells, but it is ineffective against P388 leukemia cells in mice. Additionally, it demonstrates significant inhibitory effects on streptomycetes, including actinomyces, within the brackets.

Saquayamycin B1 exhibits antibacterial properties, though its effect on Gram-negative bacteria is relatively weak. It has inhibitory effects on leukemia P388 cells and doxorubicin-resistant P388 cells.

Gilvocarcin E exhibits activity against Gram-positive bacteria and is capable of inhibiting Sarcoma 180 and P388 leukemia cells.

Diperamycin demonstrates activity against Gram-positive bacteria, including Enterococci and MRSA, with MIC ranging from 0.10 to 0.20 μg/mL. It also strongly inhibits the activity of cell lines L1210, P388, LS-180, KB, HeLaS3, Meth A, and B16-BL6, with IC50 values between 0.009 and 0.098 μg/mL.