mark

MARK-IN-1 is a potent inhibitor of microtubule affinity regulating kinase (MARK) with an IC50 of less than 0.25 nM.

MARK-IN-2 is a potent inhibitor of microtubule affinity-regulating kinase (MARK) with an IC50 of 5 nM.

MARK-IN-4, a potent inhibitor of microtubule affinity-regulated kinase (MARK) (IC50: 1 nM), presents a promising strategy for blocking neurofibrillary tangles in Alzheimer's disease.

MARK Substrate is a MARK (Microtubule Affinity-Regulating Kinase) substrate peptide.

MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis. MARK4 inhibitor 1 is a potent microtubule affinity-regulating kinase 4 (MARK4) inhibitor, with an IC50 of 1.54 μM.

MitoMark Red I is a far red fluorescent mitochondrial stain (λmax ~ 594 608 nm).

MARK4 Inhibitor 2 is a potent inhibitor of Microtubule Affinity-Regulating Kinase 4 (MARK4), exhibiting a Kₘ of 6.3×10⁷ and an IC₅₀ of 0.82 μM. It effectively inhibits the growth of human cells, thereby offering potential for use in cancer research [1].

Markogenin, a steroid constituent derived from Yucca schidigera plants [1], exhibits unique properties.

MARK4 inhibitor 4, with an IC50 value of 1.49 μM, serves as an agent targeting MARK4 for potential use in research related to cancer and tauopathies [1].

MAPK4 Inhibitor 3 (compound 23b) serves as a selective antagonist of MAPK4, demonstrating an inhibition constant (IC50) of 1.01 μM and effectively impeding the proliferation of cancer cells. This compound is utilized in research focused on cancer and tauopathies [1].

Compound 3, formally known as Kaempferol-3-O-[(6-caffeoyl)-β-glucopyranosyl (1→3) α-rhamnopyranoside]-7-O-α-rhamnopyranoside, exhibits a dose-dependent efficacy in wound healing. This compound is applicable in the research of wound repair [1].

MRT199665 is an effective and ATP-competitive, selective MARK SIK AMPK inhibitor (IC50s of 2 2 3 2 nM, 10 10 nM, and 110 12 43 nM for MARK1 MARK2 MARK3 MARK14, AMPKα1 AMPKα2, and SIK1 SIK2 SIK3, respectively). MRT199665 suppresses the phosphorylation of S

Advastab TM 188 is organometallic. It also works as an anticancer drug.

1. Darutoside (Darutin) can as an appropriate treatment for wounds. 2. Darutoside can improve skin elasticity, surface appearance and stretch mark removal, through soothing the skin, decreasing inflammation, restoring collagen and promoting collagen production.

IR-Crizotinib is a conjugate of the near-infrared dye IR-786 and Crizotinib, an NF-κB-inducing kinase (NIK) inhibitor, with an IC50 of 3.381 μM for intracranial glioblastoma (GBM) localization in mice. It has the ability to cross the blood-brain barrier and fluorescently mark GBM, and demonstrates efficacy in inhibiting glioma proliferation and invasion both in vitro and in vivo, making it significant in cancer research [1].

PCC0105003 is an effective inhibitor of MARK. This compound is utilized in the study of neuropathic pain.