mark

MARK-IN-1 is a potent inhibitor of microtubule affinity regulating kinase (MARK) with an IC50 of less than 0.25 nM.

MARK-IN-2 is a potent inhibitor of microtubule affinity-regulating kinase (MARK) with an IC50 of 5 nM.

MARK Substrate is a MARK (Microtubule Affinity-Regulating Kinase) substrate peptide.

Advastab TM 188 is organometallic. It also works as an anticancer drug.

MARK4 inhibitor 1 inhibits cancer cell proliferation, metastasis and induces apoptosis. MARK4 inhibitor 1 is a potent microtubule affinity-regulating kinase 4 (MARK4) inhibitor, with an IC50 of 1.54 μM.

MARK-IN-4, a potent inhibitor of microtubule affinity-regulated kinase (MARK) (IC50: 1 nM), presents a promising strategy for blocking neurofibrillary tangles in Alzheimer's disease.

MARK4 Inhibitor 2 is a potent inhibitor of Microtubule Affinity-Regulating Kinase 4 (MARK4), exhibiting a Kₘ of 6.3×10⁷ and an IC₅₀ of 0.82 μM. It effectively inhibits the growth of human cells, thereby offering potential for use in cancer research [1].

MARK4 inhibitor 4, with an IC50 value of 1.49 μM, serves as an agent targeting MARK4 for potential use in research related to cancer and tauopathies [1].

MAPK4 Inhibitor 3 (compound 23b) serves as a selective antagonist of MAPK4, demonstrating an inhibition constant (IC50) of 1.01 μM and effectively impeding the proliferation of cancer cells. This compound is utilized in research focused on cancer and tauopathies [1].

MitoMark Red I is a far red fluorescent mitochondrial stain (λmax ~ 594/608 nm).

Markogenin is a steroidal natural product discovered in Yucca schidigera, suitable for biochemical experiments and drug synthesis research.

Compound 3, formally known as Kaempferol-3-O-[(6-caffeoyl)-β-glucopyranosyl (1→3) α-rhamnopyranoside]-7-O-α-rhamnopyranoside, exhibits a dose-dependent efficacy in wound healing. This compound is applicable in the research of wound repair [1].

PEG300 (Polyethylene glycol 300) is a polymer formed from repeating units of ethylene glycol that is water soluble, low immunogenicity, and biocompatible. PEG300 is a neutral polymer with a molecular weight of 300.

MRT199665 is an effective and ATP-competitive, selective MARK/SIK/AMPK inhibitor (IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively). MRT199665 suppresses the phosphorylation of S

1-Hydroxypyrene (1-Pyrenol), a biomarker of exposure to polycyclic aromatic hydrocarbons, is analyzed in urine samples.

Esfenvalerate (Asana) is a widely used insecticide.

PQ-10 (A-844337) is a PDE-10 inhibitor. PQ-10 induces brain glucose metabolism patterns, which may be a potential translational biomarker.

KGP94 is an inhibitor of cysteine protease Cathepsin L(CTSL).

4-Hydroxynonenal (4-HNE) (4-HNE) is an oxidative/nitrosative stress biomarker. It is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2).

Cinnamoylglycine, a glycine conjugate of cinnamic acid and a urinary metabolite in humans, is used as a potential urinary biomarker.

Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active, competitive inhibitor of heme oxygenase-1 (HO-1) that markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2 and exhibits anti-cancer activity.

7α-Hydroxycholesterol, a cholesterol oxide formed through both enzymatic and non-enzymatic oxidation, can serve as a biomarker for lipid peroxidation.

1,3,7-Trimethyluric acid, a purine alkaloid, occurs as a minor metabolite of caffeine in humans. It functions as an antioxidant with the ability to scavenge hydroxyl radicals and offers protective benefits against lipid peroxidation in erythrocyte membranes.

Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor.