leukotriene b4

Leukotriene B4 (LTB4) is a compound derived from arachidonic acid via the 5-lipoxygenase pathway that mediates certain inflammatory and immune responses. Leukotriene B4 induces neutrophil extracellular traps that impede the clearance of Pneumocystis japonicus.

Chamazulene (Dimethulene) is a terpenoid obtained from Matricaria chamomilla L.. It possesses anti-inflammatory and antioxidant activity, inhibits leukotriene B4 formation and can be used in the study of melanoma.

γ-Linolenic Acid methyl ester (Methyl gamma-linolenate) is a weak leukotriene B4 (LTB4) receptor antagonist.

12-OxoETE is an endogenous metabolite formed during the metabolism of arachidonic acid and is present in human platelets and Aplysia nervous tissue .12-KETE induces transient changes and aggregation of intracytoplasmic free calcium ion concentration via leukotriene B4 (LTB4) receptor or coactivation sequences to achieve a rapid and dose-dependent increase.

Morolic acid and moronic acid have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an insulin sensitization with consequent changes of glucose, cholesterol and triglycerides, in part mediated by inhibition of 11β-HSD 1. Moro