l45

L-45 is the first potent and cell-active bromodomain (Brd) inhibitor of p300/CBP-associated factor (PCAF) (Kd: 126±15 nM).

Poloxamer 125 L45 is a block copolymer of polyethylene oxide and polypropylene oxide with an average molecular weight of 2400. It forms a thermoreversible hydrogel and is used as a food additive and as a drug delivery vehicle in cosmetics, pharmaceuticals, and tissue engineering.

XJTU-L453, a PI3Kα inhibitor, exhibits an IC50 of 0.4 nM. It inhibits the proliferation of breast cancer cell lines T47D and MCF7, with IC50 values of 0.2 μM and 0.5 μM respectively. Additionally, XJTU-L453 disrupts the PI3K pathway, leading to cell cycle arrest and cell apoptosis (apoptosis). It also demonstrates antitumor activity in MCF7 xenograft mice.

L458-BPyne is a γ-secretase modulator photoaffinity probe that acts by identifying distinct allosteric binding sites on presenilin. It also can be exploited to reduce levels of pathogenic Aβ species.

Tl45b is an inhibitor of AChE with an IC50 value of 0.71 μM. It is utilized in the study of Alzheimers disease.