iron-binding

L-Mimosine (Leucenol) is an antineoplastic alanine-substituted pyridine derivative isolated from Leucena glauca and acts as an iron chelator.

6-Acryloyloxyhexyl phosphater (PA21) is a novel phosphate-binding agent, which is an iron-based reagent, and can be used for the treatment of hyperphosphatemia in chronic kidney disease.

Boscalid is a broad-spectrum carboxamide fungicide that inhibits fungal respiration by binding to the ubiquinone site of mitochondrial complex II/succinate dehydrogenase.1It suppresses mycelial growth ofS. minorby 87 to 100% and ofS. sclerotiorumby 77 to 100% when used at a concentration of 1 μg/ml.2In field studies, boscalid applied at 5.6 μg/cm2provides 55.5 and 30.4% disease control for lettuce drop caused byS. minorandS. sclerotiorum, respectively. It decreases cell viability of mouse primary cortical neurons following long-term exposure but is not cytotoxic (LC50= >100 μM for acute and continuous exposure). Formulations containing boscalid have been used in agriculture to prevent fungal growth on crops. 1.Wang, Y., Duan, Y., Wang, J., et al.A new point mutation in the iron-sulfur subunit of succinate dehydrogenase confers resistance to boscalid in Sclerotinia sclerotiorumMol. Plant Pathol.16(7)653-661(2015) 2.Matheron, M.E., and Porchas, M.Activity of boscalid, fenhexamid, fluazinam, fludioxonil, and vinclozolin on growth of Sclerotinia minor and S. sclerotiorum and development of lettuce dropPlant Dis.88(6)665-668(2004)

Aniline-D5 is a deuterated isotope marker of Aniline (T207053), which can be used for isotope tracing.Aniline induces toxicity to the spleen through iron overload and oxidative stress via heme oxygenase 1 up-regulation and is able to lead to a significant increase in p-IKKα and p-IKKβ, which in turn increases NF-κB and AP-1 binding activity.

Ammonium thiocyanate is an inorganic salt commonly used to determine iron content, capable of binding with various metal ions (including copper, silver, zinc, lead, and mercury).

Haemoglobin is an iron-containing oxygen-binding protein and a globin containing haem, present in red blood cells, capable of transporting oxygen from the lungs to tissues. Haemoglobin is a multifunctional molecule involved in numerous enzymatic catalysis, nitric oxide metabolism, pH regulation, and maintaining redox balance, amongst other functions.

ML318 is a biaryl nitrile PvdQ acylase inhibitor (IC50 of 20 nM for binding in the acyl-binding site). ML318 inhibits P. aeruginosa (PAO1) with IC50 of 19 μM. ML318 prevents pyoverdine production and limits the growth of P. aeruginosa under iron-limiting

Transferrin fragment acetate is the principal ironbinding protein in animal serum and is analogous in its iron-binding site and properties to lactoferrin1.

PR280 is a potent inhibitor of dihydroceramide desaturase 1 (Des1) with an IC50 of 700 nM. It forms hydrogen bonds with amino acid residues of Des1, while its cyclopropenone group may coordinate with the iron center, stabilizing its binding at Des1's active site. This inhibits the ceramide biosynthesis pathway, preventing dihydroceramide (dhCer) from converting into ceramide. PR280 can be used in research related to sphingolipid metabolism disorders, including cancer and metabolic diseases.

ZIP14-IN-1 is a selective inhibitor of ZIP14. It can significantly inhibit the activity of ZIP14, but has no significant effect on ZIP8 (SLC39A8). ZIP14-IN-1 can effectively block the uptake of various divalent metal ions including zinc, iron, manganese and cadmium mediated by ZIP14. Its mechanism of action is to bind to the binding pocket formed at the dimer interface of ZIP14, thereby interfering with the metal ion transport pathway. In addition, ZIP14-IN-1 can reduce the levels of reactive oxygen species (ROS) and lipid peroxidation, alleviate metal-induced cytotoxicity, and can be used in related research on cancer cachexia .

N4Py is a pentadentate ligand capable of forming stable coordination complexes with metal ions such as iron and copper. It can mimic the metal-binding domain of Bleomycin. The Fe(II)-N4Py complex catalyzes the generation of reactive oxygen species (ROS), leading to oxidative DNA damage and strand breaks. Due to its ability to induce oxidative stress and DNA damage, the N4Py system is widely used in studies of anticancer mechanisms.

Erastin2 is a ferroptosis inducer and inhibitor of the system xc- cystine/glutamate transporter.[1][2] It inhibits glutamate release in CCF-STTG1 cells (IC50 = 0.0035 µM) and induces cell death in HAP1 cells at 5 µM, an effect blocked by ferrostatin-1 or deferoxamine.[1][2] Erastin2 also induces ferroptotic cell death in HT-1080 cells (EC50 = 0.15 µM), an effect blocked by β-mercaptoethanol (EC50 > 20 µM).[3] Additionally, it increases lipid peroxidation in HT-1080 cells at 1 µM.

Lactoferricin, bovine is an iron-binding glycoprotein derived from the acidic hydrolysis of bovine lactoferrin. Lactoferricin, bovine has bactericidal, antifungal, antiparasitic, antitumor, antiviral, and immunomodulatory activities [1] .

LY2928057 is a humanized antibody targeting the iron transporter SLC40A1 and acts as an iron regulator inhibitor, making it suitable for research into cardiovascular diseases. By blocking iron regulator binding and stabilizing the cell surface iron transporter, LY2928057 promotes iron release and utilization, making it applicable to research on anemia-related conditions such as chronic inflammatory anemia.

HAPSBC is a potent iron chelator of the aromatic hydrazide class with high binding affinity. It induces cellular stress by depriving cells of essential iron, used in cancer metabolism and iron overload research.

Aniline-D5 (Standard) is the standard substance of Aniline-D5, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Aniline-D5 is a deuterated isotope marker of Aniline (T207053), which can be used for isotope tracing.Aniline induces toxicity to the spleen through iron overload and oxidative stress via heme oxygenase 1 up-regulation and is able to lead to a significant increase in p-IKKα and p-IKKβ, which in turn increases NF-κB and AP-1 binding activity.

EDTA iron sodium (Standard) is a reference substance used for quantitative analysis, quality control, and biochemical research applications. EDTA iron sodium is utilized in coordination chemistry and biomedical research focused on metal chelation systems, iron ion binding dynamics, and analytical standardization of iron-containing complexes.

Transferrin is the principal iron-binding protein in animal serum and is analogous in its iron-binding site and properties to lactoferrin1. Human transferrin is a single-chain glycoprotein of molecular weight near 80,000. The molecule is arranged in two l

Conalbumin (ovotransferrin) is an egg white protein and glycoprotein with antimicrobial, antioxidant, and immunomodulatory properties as a member of the transferrin and metalloprotease families. Conalbumin has a binding logarithm of 15 for Fe3+ at pH 7 or higher.

The LinTT1 peptide is a tumor-penetrating peptide with the amino acid sequence AKRGARST. It targets peritoneal cancer (PC) by binding to the p32 (gC1qR) receptor. The LinTT1 can associate with iron oxide nanohelical (NWs) structures to form a nanocarrier that is taken up by peritoneal cancer cells in vitro and penetrates mitochondria; it also shows significant tumor-targeting and penetration effects in vivo in mice. Furthermore, LinTT1-functionalized nanocarriers combined with the pro-apoptotic peptide [D(KLAKLAK)2] demonstrate substantial tumor inhibition in a mouse peritoneal tumor model. LinTT1 peptide holds promise as a delivery vehicle for peritoneal cancer research.

CRT is an iron-peptide mimic capable of binding to apotransferrin (apo-Tf). It can be used to modify nanoparticles to enhance drug delivery efficiency.

Lactoferrin (human) is an iron-binding protein that exhibits antimicrobial properties against a variety of microorganisms, including both Gram-positive and Gram-negative bacteria, viruses, protozoa, and fungi. Additionally, Lactoferrin (human) can facilitate the cultivation of Streptococcus on iron-restricted media.

Lactoferrinfrom human milk, Iron saturated, is an iron-binding protein structurally similar to transferrin, the plasma iron transport protein, but with a higher affinity for iron.

Rabbit Transferrin is the primary iron-binding protein in plasma, responsible for transporting iron absorbed from the digestive tract and released from the breakdown of red blood cells.