inflammatory skin diseases

Pimecrolimus (SDZ-ASM 981), a calcineurin inhibitor immunosuppressant, binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineurin.

1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against skin inflammatory responses. 3. Ginkgetin is a good STAT3 inhibitor and may be a useful lead

Rocaglamide (Roc-A), isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB activation in T-cells.

Ufenamate (Flufenamic acid butyl ester) is an anthranilic acid-based anti-inflammatory drug developed for the treatment of skin diseases.

12R-LOX-IN-2 is an inhibitor of 12R-lipoxygenase (12R-LOX).12R-LOX-IN-2 inhibits imiquimod (IMQ)-induced hyperproliferation of psoriatic keratinocytes and inhibits colony formation.12R-LOX-IN-2 also decreases the protein level of Ki67 and the mRNA expression of IL-17A in IMQ-induced cells. 12R-LOX-IN-2 may be useful in the study of psoriasis and other skin-associated inflammatory diseases.

Betamethasone-17-butyrate-21-propionate is a topical corticosteroid used to treat inflammatory skin diseases.

BI605906 is an IKKβ inhibitor that inhibits tumor necrosis factor alpha-dependent IkappaB degradation and expression of the pro-inflammatory mediator interleukin-6, which can be used to study inflammatory skin diseases such as psoriasis.

All-trans-3,4-Didehydro retinoic acid (3,4-DHRA) is an active compound that regulates gene expression by binding to retinoic acid receptors (RAR), subsequently activating them. It plays a crucial role in the development and differentiation of the skin, offering potential anti-tumor and anti-inflammatory properties. Additionally, all-trans-3,4-Didehydro retinoic acid is under investigation for its ability to suppress various diseases, including skin disorders and certain types of cancer.

Deprodone is an active compound that inhibits key processes such as bacterial cell wall synthesis by interacting with hydrolase and transferase proteins of methicillin-resistant Staphylococcus aureus (MRSA). It is applied in the research of MRSA infections, inflammatory skin diseases, intestinal disorders, and fatty acid metabolism disorders.

(R)-MrgprX2 antagonist-3 is an antagonist of MrgprX2. It is applicable in the study of inflammatory skin diseases. For more detailed information, please refer to compound E118 in patent document WO2021092240A1.

EGR-1-IN-1 (IT25) is an inhibitor targeting EGR-1 with an IC50 value of 1.86 μM. This compound is useful for studies related to inflammatory skin diseases.

5α-Tetrahydrocorticosterone (5α-HB) is an endogenous steroid that acts as an agonist of the glucocorticoid receptor (GR) and a metabolite of corticosterone. It serves as an effective topical anti-inflammatory agent in vivo. In rat liver cells, it decreases the binding of metabolites to the glucocorticoid receptor-corticosterone and its 5α-reduced metabolites, with a Kd value of 268 nM. 5α-Tetrahydrocorticosterone is applicable in research on inflammatory skin diseases.

Diflorasone diacetate is a topical anti-inflammatory steroid preparation used in dermatological research to alleviate corticosteroid-responsive skin diseases.

Hydrocortamate Hydrochloride is a synthetic glucocorticoid that has anti-inflammatory and immunosuppressive properties. It is used topically to treat inflammation caused by corticosteroid-responsive skin diseases.

Lunularin is a naturally occurring bibenzyl compound widely distributed in liverworts (such as Conocephalum conicum) and is also a major gut microbiota-derived metabolite of resveratrol. Research indicates that Lunularin possesses significant antioxidant and anti-inflammatory properties and can selectively inhibit 11beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1). Due to its role in regulating glucocorticoid activation and metabolic homeostasis, this molecule is of great interest in studies involving metabolic diseases, skin health, and neuroprotection.

Trioxsalen (Trioxysalen) is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death.

Acloproxalap is a quinoline-based aldehyde scavenger used in studies of diseases with toxic aldehyde accumulation, including inflammatory diseases of the eye and skin, respiratory diseases such as pneumonia, organ diseases, and syndromes associated with viral infections[1] [2].

TRPC4/5-IN-1 can be used for the research of skin inflammatory diseases and proteinuric kidney diseases. TRPC4/5-IN-1 is a potent inhibitor of TRP channel 5/4 (TRPC5/4) with IC50 values of 0.54 μM and 2.06 μM, respectively. [1].

PF-00956980 is a reversible pan-JAK inhibitor with IC50 values of 2.2 μM for JAK1, 23.1 μM for JAK2, and 59.9 μM for JAK3, used in the study of lung and skin inflammatory diseases.

Lepzacitinib is a selective, small molecule JAK1/3 inhibitor used for the treatment of atopic dermatitis and other skin diseases. As a Janus kinase inhibitor, it reduces the inflammatory response.

Leramistat is a mitochondrial complex I (NIC1) inhibitor that alters cellular metabolism and reduces proliferation in human primary lung fibroblasts, used for treating rheumatoid arthritis.

Gymnoside I is a natural small molecule belonging to the glycoside class of hydroxybenzyl 2-isobutylmalonate, isolated from the orchid Gymnadenia conopsea. Gymnoside I exhibits antiallergic activity and demonstrates significant in vivo antiallergic activity in passive cutaneous anaphylaxis (PCA) assays in mice, effectively inhibiting allergy-mediated increases in skin vascular permeability and inflammatory exudation. Gymnoside I can be used in research on diseases such as asthma, neurasthenia, and chronic hepatitis.

IBI356 is a humanized monoclonal antibody inhibitor that targets OX40L/CD134L/CD252. It can be utilized in the study of chronic inflammatory skin diseases, such as atopic dermatitis.

Benzyl benzoate-D12 is the deuterated form of Benzyl benzoate. Benzyl benzoate (T0729) (Benzoic acid benzyl ester) is used as a fragrance component in cosmetics. It can also be utilized in research related to inflammatory skin diseases associated with scabies and Demodex mites.