inflammatory skin diseases

Ufenamate (Flufenamic acid butyl ester) is an anthranilic acid-based anti-inflammatory drug developed for the treatment of skin diseases.

Rocaglamide (Roc-A), isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB activation in T-cells.

1. Ginkgetin has anti-influenza virus and anti-fungal activities. 2. Ginkgetin has anti-inflammatory activity, can down-regulates COX-2 induction in vivo against skin inflammatory responses. 3. Ginkgetin is a good STAT3 inhibitor and may be a useful lead

12R-LOX-IN-2 is an inhibitor of 12R-lipoxygenase (12R-LOX).12R-LOX-IN-2 inhibits imiquimod (IMQ)-induced hyperproliferation of psoriatic keratinocytes and inhibits colony formation.12R-LOX-IN-2 also decreases the protein level of Ki67 and the mRNA expression of IL-17A in IMQ-induced cells. 12R-LOX-IN-2 may be useful in the study of psoriasis and other skin-associated inflammatory diseases.

Betamethasone-17-butyrate-21-propionate is a topical corticosteroid used to treat inflammatory skin diseases.

BI605906 is an IKKβ inhibitor that inhibits tumor necrosis factor alpha-dependent IkappaB degradation and expression of the pro-inflammatory mediator interleukin-6, which can be used to study inflammatory skin diseases such as psoriasis.

All-trans-3,4-Didehydro retinoic acid (3,4-DHRA) is an active compound that regulates gene expression by binding to retinoic acid receptors (RAR), subsequently activating them. It plays a crucial role in the development and differentiation of the skin, offering potential anti-tumor and anti-inflammatory properties. Additionally, all-trans-3,4-Didehydro retinoic acid is under investigation for its ability to suppress various diseases, including skin disorders and certain types of cancer.

Pimecrolimus (SDZ-ASM 981), a calcineurin inhibitor immunosuppressant, binds to the receptor macrophilin-12 (FKBP-12) forming a complex that blocks the calcium-dependent signal transduction cascade mediated by calcineurin.

Hydrocortamate Hydrochloride is a synthetic glucocorticoid that has anti-inflammatory and immunosuppressive properties. It is used topically to treat inflammation caused by corticosteroid-responsive skin diseases.

Trioxsalen (Trioxysalen) is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death.

Acloproxalap is a quinoline-based aldehyde scavenger used in studies of diseases with toxic aldehyde accumulation, including inflammatory diseases of the eye and skin, respiratory diseases such as pneumonia, organ diseases, and syndromes associated with viral infections[1] [2].

TRPC4 5-IN-1 can be used for the research of skin inflammatory diseases and proteinuric kidney diseases. TRPC4 5-IN-1 is a potent inhibitor of TRP channel 5 4 (TRPC5 4) with IC50 values of 0.54 μM and 2.06 μM, respectively. [1].

PF-00956980 is a reversible pan-JAK inhibitor with IC50 values of 2.2 μM for JAK1, 23.1 μM for JAK2, and 59.9 μM for JAK3, used in the study of lung and skin inflammatory diseases.

Lepzacitinib is a selective, small molecule JAK1 3 inhibitor used for the treatment of atopic dermatitis and other skin diseases. As a Janus kinase inhibitor, it reduces the inflammatory response.

Leramistat (HMC-C-01-A; MBS2320), a mitochondrial complex 1 inhibitor, regulates cell and immune metabolism and is effective in suppressing conditions such as atopic dermatitis, autoimmune skin diseases, inflammatory disorders, cancer, and osteoclast-mediated diseases [1].

Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid peroxidation.Hirsutenone exhibits anti-cancer, and anti-filarial effects, it may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation. Hirsutenone attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-L1 preadipocytes, underscoring the potential therapeutic application of Hirsutenone in preventing obesity.

Hemiphloin is a natural flavonoid compound. Studies have shown it to have anti-inflammatory activity and is a therapeutic candidate for inflammatory skin diseases.