fh 1

GST-FH.1 and GST-FH.4 are variants of the GST-FH compound class. GST-FH.1 often causes false positive hits (FH) in the interaction between glutathione S-transferase (GST) and glutathione (GSH). Conversely, GST-FH.4 acts as an inhibitor of glutathione S-transferase (GST), demonstrating an inhibitory concentration (IC 50) of 0.32 μM.

FH1 (NSC-12407) (BRD-K4477), a small molecule, enhances the functions of hepatocytes and promotes differentiation hepatocytes derived by iPS.

Temozolomide (TMZ) is a DNA alkylating agent with blood-brain barrier permeability and oral activity. Temozolomide has antitumor activity and antiangiogenic activity, and also induces apoptosis and autophagy. Temozolomide is stable under acidic conditions and hydrolyzes under neutral or slightly alkaline conditions.

Bevirimat (PA-457) is a first-in-class inhibitor of HIV-1 maturation, blocking the cleavage of the Gag capsid (CA) precursor, CA-SPI, to mature CA protein during virion maturation.

MP-1 is a covalent inhibitor of fumarate hydratase (FH) that exhibits cytotoxicity dependent on FH. MP-1 engages a functional cysteine in the Zn-finger domain of the tRNA methyltransferase enzyme TRMT1.

Complement factor I, a serine protease, attenuates complement activity both in the fluid phase and on cell surfaces, working alongside cofactors such as factor H (FH), complement receptor 1 (CR1 CD35), C4 binding protein (C4BP), or membrane cofactor protein (MCP CD46) [1].

Clonostachydiol is a macrodiolide-type anthelmintic derived from the fungus Clonostachys cylindrospora (strain FH-A 6607) [1].

6-N-Phthalimidoy hexanoic acid (compound FH) is a hapten featuring a carboxyl group at its spacer arm terminus, facilitating reaction with proteins' free amine groups. This compound is capable of conjugation with carrier proteins for use in antigen design [1].