farnesyltransferase

Manumycin A is an antibiotic with anticancer activity and is a mammalian thioredoxin reductase-1 (TrxR-1) inhibitor.Manumycin A inhibits the production of IL-1β, IL-6, and IL-8 in TNF alpha-stimulated THP-1 cells and peripheral blood mononuclear cells in a dose-dependent manner, inducing apoptosis.

Tectol has anti-plasmodial activity, it as a moderately active growth inhibitor with an IC50 3.44±0.20μM. It exhibited significant activity against human leukemia cell lines HL60 and CEM. Tectol may cause itchy dermatitis, the dermatitis appeared on the n

Arglabin ((+)-Arglabin) is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.

Manumycin F exhibits activity against Gram-positive bacteria and Escherichia coli, though it is largely ineffective against other Gram-negative bacteria and shows no antifungal properties. It inhibits RAS farnesyltransferase and demonstrates limited cytotoxicity against the human colon cancer cell line [HCT-116].

Manumycin G exhibits activity against Gram-positive bacteria and Escherichia coli, but shows limited effectiveness against other Gram-negative bacteria and no activity against fungi. The compound inhibits RAS farnesyltransferase and possesses moderate cytotoxic activity against the human colon cancer cell line [HCT-116].

Manumycin E exhibits activity against Gram-positive bacteria and Escherichia coli, but has limited effect on other Gram-negative bacteria and none on fungi. It inhibits RAS farnesyltransferase and demonstrates modest cytotoxic activity against the human colorectal cancer cell line [HCT-116].

Andrastin D is an inhibitor of protein farnesyltransferase, characterized by a typical androstane skeleton.

Andrastin C is an inhibitor of the protein farnesyltransferase. It features a typical androstane skeleton.

Kurasoin A is an inhibitor of the enzyme farnesyltransferase.